Day: September 16, 2021

You could be based in a university, combining chemical research with teaching; or in a public-sector research center, helping to ensure national healthcare provision keeps pace with new discoveries. In an article, author is Wei, Wen-Juan, once mentioned the application of 84-65-1, Name is Anthracene-9,10-dione, molecular formula is C14H8O2, molecular weight is 208.21, MDL number is MFCD00001188, category is thiomorpholine. Now introduce a scientific discovery about this category, Safety of Anthracene-9,10-dione.

We have successfully synthesized a new antimony-based halide hydrate, bis(thiomorpholine) pentachloroantimonate(III) monohydrate (C4NSH10)(2)[SbCl5]center dot H2O (1, C4NSH10+ is thiomorpholine cation), which crystals in a centrosymmetric space group of Pbca. 1 features the R2MX5-type perovskite architecture and undergoes a first-order structural phase transition (PT) at 406.3 K, accompanying with prominent dielectric responses. The photoluminescence spectra reveal that 1 shows a broadband light emission and a long lifetime (2.77 mu s). In addition, the DFT calculation exhibits the organic thiomorpholine cation has a contribution to electronic band structures of 1, which is distinct with other halide bismuth (Bi) and antimony (Sb)-based hybrid perovskites. This finding opens up a potential pathway to construct new lead-free hybrid materials for application of the optoelectronics. (C) 2020 Elsevier B.V. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Related Products of 3965-55-7, Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects.3965-55-7, Name is Sodium 3,5-bis(methoxycarbonyl)benzenesulfonate, SMILES is O=S(C1=CC(C(OC)=O)=CC(C(OC)=O)=C1)([O-])=O.[Na+], belongs to thiomorpholine compound. In a article, author is Martynov, Alexander V., introduce new discover of the category.

An efficient method for preparation of earlier unknown S-oxide of 2(E),6(E)-bis(chloromethylidene)-4-thiomorpholinamine by oxidation of 2(E), 6(E)-bis(chloromethylidene)-4-thiomorpholinamine hydrochloride with hydrogen peroxide in H2O or EtOH/H2O followed by the reaction mixture neutralization with Na2CO3 has been described. Interaction of the S-oxide with acetaldehyde, butanal, benzaldehyde, 4-methoxybenzaldehyde and 4-pyridinecarboxaldehyde in EtOH, C6H6, in the mixture of acetonitrile and ethanol or ethanol and benzene affords the unknown hydrazones, N-organylmethylidene-2(E), 6(E)-bis(chloromethylidene)-4-thiomorpholinamine-1-oxides. [GRAPHICS] .

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 123843-67-4, Name is 4-Bromo-2,6-difluorobenzonitrile, molecular formurla is C7H2BrF2N. In a document, author is Lima, LM, introducing its new discovery. Synthetic Route of 123843-67-4.

This paper describes the synthesis and anti-inflammatory activity of new N-phenyl-phthalimide sulfonamides (3a-e) and the isosters N-phenyl-phthalimide amides (4a-e), designed as hybrids of thalidomide (1) and aryl sulfonamide phosphodiesterase inhibitor (2), In these series, compound 3e (LASSBio 468). having a sulfonyl-thiomorpholine moiety, showed potent inhibitory activity on LPS-induced neutrophil recruitment with ED50 = 2.5 mg kg(-1), which was correlated with its inhibitory effect on TNF-alpha level. (C) 2002 Elsevier Science Ltd. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Chemical engineers work across a number of sectors, but chemistry and chemical engineering roles are found throughout, creation and manufacturing process of chemical products and materials. In an article, author is Saikia, Anil K., once mentioned the application of 90-11-9, Name is 1-Bromonaphthalene, molecular formula is C10H7Br, molecular weight is 207.07, MDL number is MFCD00003868, category is thiomorpholine. Now introduce a scientific discovery about this category, Quality Control of 1-Bromonaphthalene.

A one-pot, metal-free procedure has been developed for the synthesis of 4-tosylthiomorpholine from N-tethered thioalkenols via bromination, cyclization and subsequent elimination reaction in good yields. The reaction is found to be highly regioselective.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

You could be based in a university, combining chemical research with teaching; or in a public-sector research center, helping to ensure national healthcare provision keeps pace with new discoveries. In an article, author is Mezil, Lynda, once mentioned the application of 64-10-8, Name is 1-Phenylurea, molecular formula is C7H8N2O, molecular weight is 136.1512, MDL number is MFCD00007944, category is thiomorpholine. Now introduce a scientific discovery about this category, Related Products of 64-10-8.

Background: Targeted therapies, associated with standard chemotherapies, have improved breast cancer care. However, primary and acquired resistances are frequently observed and the development of new concepts is needed. High-throughput approaches to identify new active and safe molecules with or without an a priori” are currently developed. Also, repositioning already-approved drugs in cancer therapy is of growing interest. The thiomorpholine hydroxamate compound TMI-1 has been previously designed to inhibit metalloproteinase activity for the treatment of rheumatoid arthritis. We present here the repositioning of TMI-1 drug in breast cancer. Methodology/Principal Findings: We tested the effect of TMI-1 on luminal, basal and ERBB2-overexpressing breast tumor cell lines and on MMTV-ERBB2/neu tumor evolution. We measured the effects on i) cell survival, ii) cell cycle, iii) extrinsic and intrinsic apoptotic pathways, iv) association with doxorubicin, docetaxel and lapatinib, v) cancer stem cells compartment. In contrast with conventional cytotoxic drugs, TMI-1 was highly selective for tumor cells and cancer stem cells at submicromolar range. All non-malignant cells tested were resistant even at high concentration. TMI-1 was active on triple negative (TN) and ERBB2-overexpressing breast tumor cell lines, and was also highly efficient on human and murine primary” ERBB2-overexpressing cells. Treatment of transgenic MMTV-ERBB2/neu mice with 100 mg/kg/day TMI-1 alone induced tumor apoptosis, inhibiting mammary gland tumor occurrence and development. No adverse effects were noticed during the treatment. This compound had a strong synergistic effect in association with docetaxel, doxorubicin and lapatinib. We showed that TMI-1 mediates its selective effects by caspase-dependent apoptosis. TMI-1 was efficient in 34/40 tumor cell lines of various origins (ED50: 0.6 mu M to 12.5 mu M). Conclusions/Significance: This is the first demonstration of the tumor selective cytotoxic action of a thiomorpholin hydroxamate compound. TMI-1 is a novel repositionable drug not only for the treatment of adverse prognosis breast cancers but also for other neoplasms.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 766-98-3, Name is 1-Ethynyl-4-fluorobenzene, molecular formurla is C8H5F. In a document, author is Combourieu, B, introducing its new discovery. Recommanded Product: 766-98-3.

In situ H-1 NMR was used to monitor incubations of Mycobacterium aurum MO1 with thiomorpholine or morpholine in the presence of metyrapone, a specific inhibitor of P450. Unexpected signals were detected and assigned to metyrapol, the reduction product of metyrapone. The inhibitory effects of racemic metyrapol and of its (-)-enantiomer were compared to that of metyrapone. They are similar.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Researchers are common within chemical engineering and are often tasked with creating and developing new chemical techniques, frequently combining other advanced and emerging scientific areas. In an article, author is Ermakova, I. T., once mentioned the application of 90-30-2, Name is N-Phenyl-1-naphthylamine, molecular formula is C16H13N, molecular weight is 219.2811, MDL number is MFCD00003878, category is thiomorpholine. Now introduce a scientific discovery about this category, Reference of 90-30-2.

A screening of lignin-degrading basidial fungi that can grow in the presence of thiomorpholine derivatives (the mixture of 1,4-perhydrothiazines) has been performed. Strain Bjerkandera adusta VKM F-3477 was shown to have the maximal rate of growth in the presence of these compounds, and its capacity for thiomorpholine degradation was studied. The methods of quantitative analysis of thiomorpholine and its degradation products on the basis of thin layer chromatography and high-performance liquid chromatography were developed. It was shown that the B. adusta strain did not utilize thiomorpholine as a carbon source but transformed it into thiomorpholine sulfoxide that accumulated in the medium. Mn peroxidase produced by B. adusta in the course of thiomorpholine transformation is not directly involved in its oxidation.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. In an article, author is REDDY, DB, once mentioned the application of 93-11-8, Name is Naphthalene-2-sulfonyl chloride, molecular formula is C10H7ClO2S, molecular weight is 226.68, MDL number is MFCD00004087, category is thiomorpholine. Now introduce a scientific discovery about this category, Recommanded Product: Naphthalene-2-sulfonyl chloride.

A study of H-1-C-13 COSY spectral data of alkyl 6-aroyl-3, 5-diaryl-1, 4-thiomorpholine-1, 1-dioxide-2-carboxylates (1) leads to the revision in the previously assigned proton resonances. Solvent induced conformational changes of methyl 6-aroyl-3,5-diphenyl-1,4-thiomorpholine-1,1-dioxide-2-carboxylate (4) have been found to vary gradually with the variation in the ratio of solvents.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.you can check my other blog about 93-11-8, you can contact me at any time and look forward to more communication. Recommanded Product: Naphthalene-2-sulfonyl chloride.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

When developing chemical systems it’s of course important to gain a deep understanding of the chemical reaction process. In an article, author is Bae, HS, once mentioned the application of 23676-09-7, Name is Ethyl 4-ethoxybenzoate, molecular formula is C11H14O3, molecular weight is 194.23, MDL number is MFCD00009116, category is thiomorpholine. Now introduce a scientific discovery about this category, Recommanded Product: 23676-09-7.

Biodegradability of secondary amines (pyrrolidine, piperidine, piperazine, morpholine, and thiomorpholine) under anaerobic conditions was examined in microbial consortia from six different environmental sites. The consortia degraded pyrrolidine and piperidine under denitrifying conditions. Enrichment cultures were established by repeatedly sub-culturing the consortia on pyrrolidine or piperidine in the presence of nitrate. The enrichments strictly required nitrate for the anaerobic degradation and utilized pyrrolidine or piperidine as a carbon, nitrogen, and energy source for their anaerobic growths. The anaerobic degradation of pyrrolidine and piperidine reduced nitrate to nitrogen gas, indicating that these anaerobic degradations were coupled with a respiratory nitrate reduction. (C) 2002 Elsevier Science Ltd. All rights reserved.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves., Related Products of 766-98-3, 766-98-3, Name is 1-Ethynyl-4-fluorobenzene, molecular formula is C8H5F, belongs to thiomorpholine compound. In a document, author is Marvadi, Sandeep Kumar, introduce the new discover.

This study describes synthesis and evaluation of novel 5-Chloro-2-thiophenyl-1,2,3-triazolylmethyldihydroquinolines 7a-o as dual inhibitors of Mycobacterium tuberculosis and influenza virus. Huisgen’s [ 3+ 2] dipolar cycloaddition of 6-(azidomethyl)-5-chloro-2-(thiophen-2-yl)-7,8-dihydroquinoline 5 with various alkynes 6a-o using sodium ascorbate and copper sulphate gave new dihydroquinoline-1,2,3-triazoles 7a-o in good to excellent yields. The new compounds were evaluated for in vitro antimycobacterial against M. tuberculosis H37Rv (Mtb) and antiviral activity against influenza virus A/Puerto Rico/8/34 (H1N1). Among the fifteen new analogs, compounds 7a (MIC: 3.12 mu g/mL), 7j and 7k (MIC: 6.25 mu g/mL) were identified as potent antitubercular agents. The virus-inhibiting activity of all the fifteen compounds was found to be moderate, and among them the compound 7l, bearing thiophene moiety appeared the most active with good selectivity index (IC50 = 19.5 mu g/mL; SI = 15). The results presented here will help developing newer dual inhibitors of tuberculosis and influenza virus.

The result showed that such a combination of chemo- and biocatalysis improved the catalytic yield more than two times compared with that of sole metal catalysis.you can check my other blog about 766-98-3, you can contact me at any time and look forward to more communication. Related Products of 766-98-3.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem