Healthcare careers for chemists are once again largely based in laboratories, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 123843-67-4, Name is 4-Bromo-2,6-difluorobenzonitrile, molecular formurla is C7H2BrF2N. In a document, author is Lima, LM, introducing its new discovery. Synthetic Route of 123843-67-4.
This paper describes the synthesis and anti-inflammatory activity of new N-phenyl-phthalimide sulfonamides (3a-e) and the isosters N-phenyl-phthalimide amides (4a-e), designed as hybrids of thalidomide (1) and aryl sulfonamide phosphodiesterase inhibitor (2), In these series, compound 3e (LASSBio 468). having a sulfonyl-thiomorpholine moiety, showed potent inhibitory activity on LPS-induced neutrophil recruitment with ED50 = 2.5 mg kg(-1), which was correlated with its inhibitory effect on TNF-alpha level. (C) 2002 Elsevier Science Ltd. All rights reserved.
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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem