Day: September 30, 2021

Authors Kudale, VS; Wang, JJ in ROYAL SOC CHEMISTRY published article about PALLADIUM-CATALYZED ALKYLATION; THERMAL OXIDATIVE-DEGRADATION; POLYETHYLENE-GLYCOL; STEREOSELECTIVE-SYNTHESIS; SELECTIVE ALKYLATION; ALPHA-METHYLATION; C(SP(3))-H BONDS; METHANOL; ARYLACRYLAMIDES; HETEROCYCLES in [Kudale, Vishal Suresh; Wang, Jeh-Jeng] Kaohsiung Med Univ, Dept Med & Appl Chem, 100,Shiquan 1st Rd, Kaohsiung 807, Taiwan; [Wang, Jeh-Jeng] Kaohsiung Med Univ Hosp, Dept Med Res, 100 Tzyou 1st Rd, Kaohsiung 807, Taiwan in 2020, Cited 59. Category: thiomorpholine. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The generation of a methyl carbon source from renewable and cheap sources is challenging. Herein, we describe a novel and an efficient route for methylation and acetylation of aza-heteroarenes using PEG-400 under O-2 and TsOH center dot H2O for the first time by tuning the reaction conditions using a different set of starting materials. The key features of the current protocol are oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance, and a broad substrate scope. The potential applicability of the designed methodology was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug molecules by a one-pot strategy.

Category: thiomorpholine. About 2-Aminobenzamide, If you have any questions, you can contact Kudale, VS; Wang, JJ or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Visible-light-induced oxidative coupling of vinylarenes with diselenides leading to alpha-aryl and alpha-alkyl selenomethyl ketones WOS:000629630600031 published article about DIPHENYL DISELENIDE; ALDEHYDES; SELENIDES; OLEFINS in [Liu, Gong-Qing; Yi, Wei; Wang, Peng-Fei; Liu, Ji; Ma, Meng; Hao, Da-Yun; Ming, Liang; Ling, Yong] Nantong Univ, Sch Pharm, 19 Qixiu Rd, Nantong 226001, Peoples R China in 2021.0, Cited 98.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9. Quality Control of Benzophenone

A visible-light-induced oxidative coupling of diselenides with readily available vinylarenes is demonstrated. This benign protocol allows one to access a wide range of alpha-aryl and alpha-alkyl selenomethyl ketones in good yields with excellent functional group compatibility. The distinct advantages of this protocol over all previous methods include the use of a green solvent and air as an oxidant and the lack of a photocatalyst, a base, and an oxidant as well as better green chemistry matrices. Furthermore, the title reaction can be performed with natural sunlight, the most sustainable energy source imaginable. Additionally, the mild reaction conditions, easy operation and suitability for the modification of styrene-functionalized biomolecules make the current reaction system a more attractive method for the synthesis of a variety of medicinal and agrochemical compounds of interest.

About Benzophenone, If you have any questions, you can contact Liu, GQ; Yi, W; Wang, PF; Liu, J; Ma, M; Hao, DY; Ming, L; Ling, Y or concate me.. Quality Control of Benzophenone

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Quality Control of Benzophenone. Recently I am researching about VISIBLE-LIGHT PHOTOCATALYSIS; ALPHA-OXOCARBOXYLIC ACIDS; METAL-FREE CATALYST; C-H ACTIVATION; CARBOXYLIC-ACIDS; OXIDATIVE CLEAVAGE; TRANSITION-METAL; PHOTOREDOX CATALYSIS; SELECTIVE OXIDATION; BRANCHED ALDEHYDES, Saw an article supported by the Shaanxi University of Science & Technology and Education Foundation of Shaanxi Province [18JK0105]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Xie, P; Xue, C; Wang, CC; Du, DD; Shi, SS. The CAS is 119-61-9. Through research, I have a further understanding and discovery of Benzophenone

A CF3SO2Na/Pd(OAc)(2) co-catalysis strategy was developed to produce aryl ketones via visible-light-induced decarboxylative cross-coupling of alpha-oxocarboxylic acids and aryl boronic acids. This process was performed under air at room temperature, furnishing aromatic ketones in moderate to good yields. Various sensitive functional groups were well tolerated in this reaction. A synergistic catalytic mechanism involving O-2 was also proposed based on the experimental observations.

Quality Control of Benzophenone. About Benzophenone, If you have any questions, you can contact Xie, P; Xue, C; Wang, CC; Du, DD; Shi, SS or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Cheng, DP; Yan, XH; Pu, YQ; Shen, J; Xu, XL; Yan, JZ in WILEY-V C H VERLAG GMBH published article about CATALYZED SYNTHESIS; METAL-FREE; DERIVATIVES; QUINAZOLINONES; CYCLIZATION; ALDEHYDES; 2,3-DIHYDRO-4(1H)-QUINAZOLINONES; INHIBITORS; EFFICIENT; CHLORIDE in [Cheng, Dongping; Yan, Xianhang; Pu, Yueqi; Shen, Jing; Yan, Jizhong] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China; [Xu, Xiaoliang] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China in 2021, Cited 56. Category: thiomorpholine. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

An efficient tandem oxidative annulation for the synthesis of 2,2-disubstituted 2,3-dihydroquinazolin-4(1H)-ones via DDQ-mediated dual cross-dehydrogenative-coupling (CDC) reactions is described. This transformation proceeds from easily available o-aminobenzamides and 1,3-diarylpropenes under mild conditions, and the corresponding products are obtained in moderate to excellent yields.

About 2-Aminobenzamide, If you have any questions, you can contact Cheng, DP; Yan, XH; Pu, YQ; Shen, J; Xu, XL; Yan, JZ or concate me.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: C14H10O. In 2019 SCI TOTAL ENVIRON published article about ARYL-HYDROCARBON RECEPTOR; POLYCYCLIC AROMATIC-HYDROCARBONS; ESTROGEN-RECEPTOR; CELL-LINE; IN-VITRO; PARTICULATE MATTER; EPITHELIAL-CELLS; DNA-DAMAGE; ACTIVATION; EXPOSURE in [Pencikova, Katerina; Ciganek, Miroslav; Neca, Jiri; Machala, Miroslav] Vet Res Inst, Dept Chem & Toxicol, Hudcova 70, Brno 62100, Czech Republic; [Illes, Peter; Dvorak, Zdenek] Palacky Univ, Fac Sci, Dept Cell Biol & Genet, Slechtitelu 27, Olomouc 78371, Czech Republic; [Vondracek, Jan] Czech Acad Sci, Inst Biophys, Dept Cytokinet, Kralovopolska 135, Brno 61265, Czech Republic in 2019, Cited 65. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8.

Organic pollutants associated with diesel exhaust particles (DEP), such as polycyclic aromatic hydrocarbons (PAHs) and their derivatives, may negatively impact human health. However, a comprehensive overview of their effects on endocrine nuclear receptor activities is still missing. Here, we evaluated the effects of extracts and chromatographic fractions (fractionated according to increasing polarity) of two standard reference materials derived from distinct types of diesel engines (SRM 2975, SRM 1650b), on activation of androgen receptor (AR), estrogen receptor alpha (ER alpha), peroxisome proliferator-activated receptor gamma (PPAR gamma), glucocorticoid receptor (GR) and thyroid receptor alpha (TR alpha), using human cell-based reporter gene assays. Neither DEP standard modulated AR or GR activities. Crude extracts and fractions of SRM 1650b and SRM 2975 suppressed ER alpha-mediated activity in the ER-CALUX (TM) assay; however, this effect could be partly linked to their cytotoxicity in this cell line. We observed that only SRM 2975 extract and its fractions were partial PPAR gamma inducers, while SRM 1650b extract was not active towards this receptor. Importantly, we found that both extracts and polar fractions of SRM activated TR alpha and significantly potentiated the activity of endogenous TR alpha ligand, triiodothyronine. Based on a detailed chemical analysis of both extracts and their polar fractions, we identified several oxygenated PAH derivatives, that were present at relatively high levels in the analyzed DEP standards, including 3-nitrobenzanthrone (3-NBA), anthracene-9,10-dione, phenanthrene-9,10-dione. 9H-fluoren-9-one or benzo[a] anthracene-7,12-dione, to activate TR alpha activity. Nevertheless, these compounds provided only a minor contribution to the overall TR alpha activity identified in polar fractions. This suggests that yet unidentified polar polyaromatic compounds associated with DEP may, apart from their known impact on the aryl hydrocarbon receptor or steroid signaling, deregulate activities of additional nuclear receptors, in particular of TR alpha. This illustrates the need to better characterize endocrine disrupting activities of DEP. (C) 2019 Elsevier B.V. All rights reserved.

About Anthrone, If you have any questions, you can contact Pencikova, K; Ciganek, M; Neca, J; Illes, P; Dvorak, Z; Vondracek, J; Machala, M or concate me.. COA of Formula: C14H10O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Name: 3-Nitrobenzaldehyde. Authors Dutta, A; Rohman, MA; Nongrum, R; Thongni, A; Mitra, S; Nongkhlaw, R in ROYAL SOC CHEMISTRY published article about in [Dutta, Arup; Rohman, Mostofa A.; Thongni, Aiborlang; Mitra, Sivaprasad; Nongkhlaw, Rishanlang] North Eastern Hill Univ, Dept Chem, Ctr Adv Studies Chem, Shillong 793022, Meghalaya, India; [Nongrum, Ridaphun] Sankardev Coll, Shillong, Meghalaya, India in 2021.0, Cited 41.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

Herein, we report an intramolecular radical cyclization reaction towards the synthesis of pyrrolidinone derivatives via metal-free photoredox catalysis under irradiation from blue LEDs. Some of the remarkable features of this protocol include synthetic efficiency, green reaction profile, easy isolation of products and short reaction time. The photophysical properties of synthesized compounds were investigated via steady state and time-resolved fluorescence spectroscopy in the solid state. Results showed the promising opportunity for their spectral tuning together with large Stokes-shifted and highly active fluorescence emission, thus indicating that these molecular scaffolds can be effective probes for the biological applications and development of opto-electronic devices.

Name: 3-Nitrobenzaldehyde. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Dutta, A; Rohman, MA; Nongrum, R; Thongni, A; Mitra, S; Nongkhlaw, R or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Koohestani, F; Sadjadi, S; Heravi, M in NATURE RESEARCH published article about in [Koohestani, Fatemeh; Sadjadi, Samahe] Iran Polymer & Petrochem Inst, Fac Petrochem, Gas Convers Dept, POB 14975-112, Tehran, Iran; [Heravi, Majid] Alzahra Univ, Sch Phys & Chem, Dept Chem, POB 1993891176, Tehran, Iran in 2021, Cited 35. Formula: C7H5NO3. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

Combining the encapsulating capability of cyclodextrin and instinctive features of bentonite clay, a versatile metal free catalyst has been developed that could promote various chemical reactions such as Knoevenagel condensation, synthesis of xanthan and octahydroquinazolinones in aqueous media under ultrasonic irradiation. To prepare the catalyst, bentonite was Cl-functionalized and then reacted with isatin and guanidine successively to furnish amino functionalized bentonite. The latter then reacted with tosylated cyclodextrin. The resultant catalytic composite was characterized via XRD, SEM, EDS, BET, elemental mapping analysis, TGA and FTIR. The catalytic activity tests approved excellent activity of the catalyst as well as broad substrate scope. Notably, the catalyst could be simply recovered and reused for several reaction runs. Moreover, the activity of the composite was superior to that of its components.

Formula: C7H5NO3. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Koohestani, F; Sadjadi, S; Heravi, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Dabiri, M; Lehi, NF; Movahed, SK; Khavasi, HR in WILEY-V C H VERLAG GMBH published article about C-H; NATURAL-PRODUCTS; ACYLATION; QUINAZOLINONES; ALDEHYDES; QUINAZOLIN-4(3H)-ONES; ANILIDES; BONDS in [Dabiri, Minoo; Lehi, Noushin Farajinia; Movahed, Siyavash Kazemi; Khavasi, Hamid Reza] Shahid Beheshti Univ, Fac Chem & Petr Sci, Dist 1,Daneshjou Blvd, Tehran 1983969411, Tehran Province, Iran in 2019, Cited 38. Safety of 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The palladium-catalyzed cross-dehydrogenative coupling (CDC) followed by an intramolecular cyclization between arylquinazolinones and aldehydes has been described. This viable transformation provides a variety of novel substituted hydroxyisoindolo[1,2-b]quinazolinone compounds in moderate to good yields. Additionally, the reaction is performed with toluene in place of benzaldehyde by using an excess amount of tert-butyl hydroperoxide (TBHP) as the oxidant in good yield.

Safety of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Dabiri, M; Lehi, NF; Movahed, SK; Khavasi, HR or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Safety of Anthrone. Byrne, AJ; Bright, SA; McKeown, JP; O’Brien, JE; Twamley, B; Fayne, D; Williams, DC; Meegan, MJ in [Byrne, Andrew J.; McKeown, James P.; Meegan, Mary J.] Trinity Coll Dublin, Sch Pharm & Pharmaceut Sci, Trinity Biomed Sci Inst, 152-160 Pearse St, Dublin D02 R590 2, Ireland; [Bright, Sandra A.; Fayne, Darren; Williams, D. Clive] Trinity Coll Dublin, Sch Biochem & Immunol, Trinity Biomed Sci Inst, 152-160 Pearse St, Dublin D02 R590 2, Ireland; [O’Brien, John E.; Twamley, Brendan] Trinity Coll Dublin, Sch Chem, Trinity Biomed Sci Inst, 152-160 Pearse St, Dublin D02 R590 2, Ireland published Design, Synthesis and Biochemical Evaluation of Novel Ethanoanthracenes and Related Compounds to Target Burkitt’s Lymphoma in 2020, Cited 73. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8.

Lymphomas (cancers of the lymphatic system) account for 12% of malignant diseases worldwide. Burkitt’s lymphoma (BL) is a rare form of non-Hodgkin’s lymphoma in which the cancer starts in the immune B-cells. We report the synthesis and preliminary studies on the antiproliferative activity of a library of 9,10-dihydro-9,10-ethanoanthracene based compounds structurally related to the antidepressant drug maprotiline against BL cell lines MUTU-1 and DG-75. Structural modifications were achieved by Diels-Alder reaction of the core 9-(2-nitrovinyl)anthracene with number of dienophiles including maleic anhydride, maleimides, acrylonitrile and benzyne. The antiproliferative activity of these compounds was evaluated in BL cell lines EBV- MUTU-1 and EBV+ DG-75 (chemoresistant). The most potent compounds 13j, 15, 16a, 16b, 16c, 16d and 19a displayed IC50 values in the range 0.17-0.38 mu M against the BL cell line EBV- MUTU-1 and IC50 values in the range 0.45-0.78 mu M against the chemoresistant BL cell line EBV+ DG-75. Compounds 15, 16b and 16c demonstrated potent ROS dependent apoptotic effects on the BL cell lines which were superior to the control drug taxol and showed minimal cytotoxicity to peripheral blood mononuclear cells (PBMCs). The results suggest that this class of compounds merits further investigation as antiproliferative agents for BL.

About Anthrone, If you have any questions, you can contact Byrne, AJ; Bright, SA; McKeown, JP; O’Brien, JE; Twamley, B; Fayne, D; Williams, DC; Meegan, MJ or concate me.. Safety of Anthrone

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Fan, ZJ; Shi, J; Luo, N; Bao, XP in [Fan, Zhijiang; Shi, Jun; Luo, Na; Bao, Xiaoping] Guizhou Univ, Ctr Res & Dev Fine Chem, Minist Educ,Key Lab Green Pesticide & Agr Bioengn, State Key Lab Breeding Base Green Pesticide & Agr, Guiyang 550025, Guizhou, Peoples R China published Synthesis, crystal structure and antimicrobial activity of 2-((2-(4-(1H-1,2,4-triazol-1-yl)phenyl)quinazolin-4-yl)oxy)-N-phenylacetamide derivatives against phytopathogens in 2019, Cited 29. Recommanded Product: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A total of eighteen 2-((2-(4-(1H-1,2,4-triazol-1-yl)phenyl)quinazolin-4-yl)oxy)-N-phenylacetamide derivatives were designed and synthesized, via hybrid pharmacophore approach. Among these compounds, chemical structure of compound 4a was unambiguously confirmed by means of single-crystal X-ray diffraction analysis. All the compounds were evaluated in vitro for their inhibition activity against several important phytopathogenic bacteria and fungi in agriculture. The obtained results indicated that several compounds demonstrated potent antibacterial activity against Xanthomonas oryzae pv. oryzae (Xoo). For example, compounds 4c, 4g and 4q had EC50 values of 35.0, 36.5 and 32.4 mu g/mL toward this bacterium, respectively, around 1.5 times more active than commercial bactericide bismerthiazol (EC50 = 89.8 mu g/mL). Additionally, compounds 4j and 4p were found to display comparable antifungal activity against Gloeosporium fructigenum at 50 mu g/mL, to commercial fungicide hymexazol. Finally, the relationships between antibacterial activities and molecular structures of this class of compounds were discussed in detail. [GRAPHICS] .

About 2-Aminobenzamide, If you have any questions, you can contact Fan, ZJ; Shi, J; Luo, N; Bao, XP or concate me.. Recommanded Product: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem