Authors Cadena-Cruz, JE; Guaman-Ortiz, LM; Romero-Benavides, JC; Bailon-Moscoso, N; Murillo-Sotomayor, KE; Ortiz-Guaman, NV; Heredia-Moya, J in BMC published article about SOLID ACID CATALYST; EFFICIENT; DERIVATIVES; APOPTOSIS; EDARAVONE; REGULATORS; AUTOPHAGY; PYRAZOLE; DFT in [Cadena-Cruz, Jose Eduardo] Univ Cent Ecuador, Fac Ciencias Quim, Quito, Ecuador; [Guaman-Ortiz, Luis M.; Bailon-Moscoso, Natalia; Murillo-Sotomayor, Kevin E.; Ortiz-Guaman, Nadia V.] Univ Tecn Particular Loja, Dept Ciencias Salud, San Cayetano Alto S-N, Loja 1101608, Ecuador; [Romero-Benavides, Juan Carlos] Univ Tecn Particular Loja, Dept Quim & Ciencias Exactas, San Cayetano Alto S-N, Loja 1101608, Ecuador; [Heredia-Moya, Jorge] Univ UTE, Fac Ciencias Salud Eugenio Espejo, Ctr Invest Biomed CENBIO, Quito 170527, Ecuador in 2021, Cited 51. Product Details of 99-61-6. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6
Background Pyrazoles have attracted particular attention due to the diverse biological activities associated with this heterocyclic system, and some have been shown to be cytotoxic to several human cell lines. Several drugs currently on the market have this heterocycle as the key structural motif, and some have been approved for the treatment of different types of cancer. Results 4,4MODIFIER LETTER PRIME-(Arylmethylene)bis(1H-pyrazol-5-ols) derivatives 3a-q were synthetized by a three components reaction of 3-methyl-1-phenyl-5-pyrazolone (1) with various benzaldehydes 2 catalyzed by sodium acetate at room temperature. The structures of all synthesized compounds were characterized by physicochemical properties and spectral means (IR and NMR) and were evaluated for their radical scavenging activity by DPPH assay and tested in vitro on colorectal RKO carcinoma cells in order to determine their cytotoxic properties. All 4,4MODIFIER LETTER PRIME-(arylmethylene)bis(1H-pyrazol-5-ols) derivatives 3a-q were synthetized in high to excellent yield, and pure products were isolated by simple filtration. All compounds have good radical scavenging activity, and half of them are more active than ascorbic acid used as standard. Conclusion Several derivatives proved to be cytotoxic in the RKO cell line. In particular, compound 3i proved to be a very potent scavenger with an IC50 of 6.2 +/- 0.6 mu M and exhibited an IC50 of 9.9 +/- 1.1 mu M against RKO cell. Autophagy proteins were activated as a survival mechanism, whereas the predominant pathway of death was p53-mediated apoptosis.
Product Details of 99-61-6. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Cadena-Cruz, JE; Guaman-Ortiz, LM; Romero-Benavides, JC; Bailon-Moscoso, N; Murillo-Sotomayor, KE; Ortiz-Guaman, NV; Heredia-Moya, J or concate me.
Reference:
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