Day: October 9, 2021

Arslan, M; Ceylan, O; Arslan, R; Tasdelen, MA in [Arslan, Mehmet; Arslan, Rabia; Tasdelen, Mehmet Atilla] Yalova Univ, Fac Engn, Dept Polymer Mat Engn, TR-77100 Yalova, Turkey; [Ceylan, Ozgur] Yalova Univ, Cent Res Lab, TR-77100 Yalova, Turkey published Facile UV-induced covalent modification and crosslinking of styrene-isoprene-styrene copolymer via Paterno-Buchi [2+2] photocycloaddition in 2021.0, Cited 40.0. Computed Properties of C13H10O. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9.

The chemical functionalization or modification of polymers to alter or improve the physical and mechanical properties constitutes an important field in macromolecular research. Fabrication of polymeric materials via structural tailoring of commercial or commodity polymers that are produced in vast quantities especially possess unique advantages in material applications. In the present study, we report on benign chemical modification of unsaturated styrene-isoprene-styrene (SIS) copolymer using available backbone alkene groups. Covalent attachment of aldehyde functional substrates onto reactive isoprene double bond residues was conveniently carried out using UV-induced Paterno-Buchi [2 + 2] cycloaddition. Model organic compounds with different structures were utilized in high efficiency chemical modification of parent polymer chains via oxetane ring formation. Functionalization studies were confirmed via(1)H NMR, FT-IR and SEC analyses. The methodology was extended to covalent crosslinking of polymer chains to obtain organogels with tailorable crosslinking degrees and physical characteristics. Considering the outstanding elastic properties of unsaturated rubbers and their high commercial availability, abundant reactive double bonds in backbone chains of these polymers offer easy to implement structural modification via proposed Paterno-Buchi photocycloaddition.

About Benzophenone, If you have any questions, you can contact Arslan, M; Ceylan, O; Arslan, R; Tasdelen, MA or concate me.. Computed Properties of C13H10O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy WOS:000610494400011 published article about PARP INHIBITORS; DNA-REPAIR; BRD4; DISCOVERY; LETHALITY; ADAPTER; TUMORS in [Chang, Xiaosa; Sun, Dejuan; Shi, Danfeng; Wang, Guan; Chen, Yanmei; Zhang, Kai; Tan, Huidan; Liu, Jie; Liu, Bo; Ouyang, Liang] Sichuan Univ, West China Hosp, State Key Lab Biotherapy & Canc Ctr, Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China in 2021, Cited 72. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Name: 2-Aminobenzamide

This study was aimed to design the first dual-target small-molecule inhibitor co-targeting poly (ADP-ribose) polymerase-1 (PARP1) and bromodomain containing protein 4 (BRD4), which had important cross relation in the global network of breast cancer, reflecting the synthetic lethal effect. A series of new BRD4 and PARP1 dual-target inhibitors were discovered and synthesized by fragment-based combinatorial screening and activity assays that together led to the chemical optimization. Among these compounds, 19d was selected and exhibited micromole enzymatic potencies against BRD4 and PARP1, respectively. Compound 19d was further shown to efficiently modulate the expression of BRD4 and PARP1. Subsequently, compound 19d was found to induce breast cancer cell apoptosis and stimulate cell cycle arrest at G1 phase. Following pharmacokinetic studies, compound 19d showed its antitumor activity in breast cancer susceptibility gene 1/2 (BRCA1/2) wild-type MDA-MB-468 and MCF-7 xenograft models without apparent toxicity and loss of body weight. These results together demonstrated that a highly potent dual-targeted inhibitor was successfully synthesized and indicated that co-targeting of BRD4 and PARP1 based on the concept of synthetic lethality would be a promising therapeutic strategy for breast cancer. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

About 2-Aminobenzamide, If you have any questions, you can contact Chang, XS; Sun, DJ; Shi, DF; Wang, G; Chen, YM; Zhang, K; Tan, HD; Liu, J; Liu, B; Ouyang, L or concate me.. Name: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Name: 4-Methoxybenzyl acetate. In 2020 ORG BIOMOL CHEM published article about C-N BOND; SILVER-FREE; 2,3-DISUBSTITUTED BENZOFURANS; CATALYZED CYCLIZATION; GOLD CATALYSIS; COMPLEXES; ALKYNES; CARBOALKOXYLATION; CARBOTHIOLATION; REACTIVITY in [Le, Quang; Dillon, Christopher C.; Lichtenstein, Dana A.; Pisor, Jeremy W.; Closser, Kristina D.; Muchalski, Hubert] Calif State Univ Fresno, 2555 E San Ramon Ave M-S SB70, Fresno, CA 93740 USA in 2020, Cited 46. The Name is 4-Methoxybenzyl acetate. Through research, I have a further understanding and discovery of 104-21-2.

Homogeneous cationic gold(i) catalysis emerged as a preferred avenue for the activation of alkenes and alkynes towards reactions with weak nucleophiles, especially in cyclization reactions. Here we report an intramolecular carboalkoxylation reaction of electron-rich benzyl ethers of 2-ethynylaryl phenols catalysed by a digold(i)-NHC complex. The reaction proceeds efficiently with low catalyst loading and the resulting 2,3-disubstituted benzofurans form in moderate to good yields. Based on the results of a cross-over experiment, spectroscopic data, and DFT calculations, we propose a mechanism that accounts for the observed chemo- and regioselectivity.

About 4-Methoxybenzyl acetate, If you have any questions, you can contact Le, Q; Dillon, CC; Lichtenstein, DA; Pisor, JW; Closser, KD; Muchalski, H or concate me.. Name: 4-Methoxybenzyl acetate

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2019 ACS CATAL published article about CHIRAL AMMONIUM BETAINES; APROTIC IMIDAZOLIUM ZWITTERION; MANNICH-TYPE REACTION; AZA-HENRY REACTION; CARBON-DIOXIDE; MOLTEN-SALT; EFFICIENT; ORGANOCATALYSIS; MILD; PROTONATION in [Lam, Ying-Pong; Wang, Xinyan; Tan, Fei; Ng, Wing-Hin; Tse, Ying-Lung Steve; Yeung, Ying-Yeung] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China in 2019, Cited 70. The Name is 4-Methoxybenzyl acetate. Through research, I have a further understanding and discovery of 104-21-2. COA of Formula: C10H12O3

A class of zwitterionic organocatalysts based on an amide anion/iminium cation charge pair has been developed. The zwitterions are easily prepared by reacting aziridines with aminopyridines. They are catalytically applicable to transesterifications and dehydrative esterifications. Mechanistic studies reveal that the amide anion and iminium cation work synergistically in activating the reaction partners, with the iminium cationic moiety interacting with the carbonyl substrates through nonclassical hydrogen bonding. The reaction can be applied to large-scale synthesis of biodiesel under mild conditions.

COA of Formula: C10H12O3. About 4-Methoxybenzyl acetate, If you have any questions, you can contact Lam, YP; Wang, XY; Tan, F; Ng, WH; Tse, YLS; Yeung, YY or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Application of Yttrium Iron Garnet as a Powerful and Recyclable Nanocatalyst for One-Pot Synthesis of Pyrano[2,3-c]pyrazole Derivatives under Solvent-Free Conditions WOS:000511152000018 published article about CONJUGATED MAGNETIC NANOPARTICLES; EFFICIENT; CATALYST in [Sedighinia, E.; Badri, R.] Islamic Azad Univ, Dept Chem, Khouzestan Sci & Res Branch, Ahwaz, Iran; [Sedighinia, E.; Badri, R.] Islamic Azad Univ, Dept Chem, Ahvaz Branch, Ahwaz, Iran; [Kiasat, A. R.] Shahid Chamran Univ, Coll Sci, Dept Chem, Ahwaz 6135743169, Iran in 2019, Cited 30. The Name is 4-Methoxybenzyl acetate. Through research, I have a further understanding and discovery of 104-21-2. COA of Formula: C10H12O3

The application of yttrium iron garnet (YIG) superparamagnetic nanoparticles as a new recyclable and highly efficient heterogeneous magnetic catalyst for one-pot synthesis of pyrano[2,3-c]pyrazole derivatives under solvent-free conditions, as well as etherification and esterification reactions are described. The advantages of the proposed method include the lack of organic solvents, clean reaction, rapid removal of the catalyst, short reaction times, excellent yields, and recyclability of the catalyst.

About 4-Methoxybenzyl acetate, If you have any questions, you can contact Sedighinia, E; Badri, R; Kiasat, AR or concate me.. COA of Formula: C10H12O3

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Biotechnology & Applied Microbiology; Plant Sciences very interesting. Saw the article VvWRKY13 from Vitis vinifera negatively modulates salinity tolerance published in 2019. SDS of cas: 90-44-8, Reprint Addresses Liu, X (corresponding author), Qingdao Agr Univ, Key Lab Plant Biotechnol Univ Shandong Prov, Coll Life Sci, Qingdao 266109, Shandong, Peoples R China.. The CAS is 90-44-8. Through research, I have a further understanding and discovery of Anthrone

WRKY transcription factors participate in the salt stress responses of various plant species, but the underlying functional mechanisms are not well understood, particularly in grape. In this study, the role of VvWRKY13 in the salt stress response was characterized and the underlying physiological and molecular mechanisms were explored. The results show that VvWRKY13 expression was induced by salt stress, and the VvWRKY13 transcript level in the salt stress-sensitive cultivar was significantly higher than that in the resistant cultivars. Overexpression of VvWRKY13 in Arabidopsis significantly inhibited the growth of transgenic plants under salt stress, indicating that VvWRKY13 has a negative effect on the salt stress response. The photosynthetic rate, contents of proline and soluble sugars, activities of superoxide dismutase (SOD) and catalase (CAT), as well as transcriptional levels of proline and soluble sugar metabolic genes, such as P5CS1, SS1, SS2 and G6PDH, as well as SOD and CAT encoding genes CAT1, CAT2, and Cu/Zn-SOD, all decreased under salt stress, whereas hydrogen peroxide and oxygen-free radical contents increased in transgenic Arabidopsis plants compared with those of wild-type plants. VvWRKY13 suppressed upregulation of SnRK2.3, ABF1, ABF2, ABF3, RD29B, RD29A, and RAB18 induced by salt stress, but showed no significant effect on the transcript levels of SnRK2.2, SnRK2.6, or RD22, indicating that VvWRKY13 affects salt stress tolerance via a specific abscisic acid signaling pathway. Key message VvWRKY13, isolated from grapevine, negatively regulate salt stress tolerance by depressing photosynthetic capacity, inhibiting salt-induced accumulation of osmolytes andup-regulation in antioxidant activity as well as expression of related genes. VvWRKY13 may affects salt stress tolerance by specific ABA signalling.

About Anthrone, If you have any questions, you can contact Che, YM; Zhang, Z; Zhu, D; Hao, J; Hou, LX; Liu, X or concate me.. SDS of cas: 90-44-8

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Bouhrim, M; Ouassou, H; Loukili, E; Ramdani, M; Mekhfi, H; Ziyyat, A; Legssyer, A; Aziz, M; Bnouham, M in WOLTERS KLUWER MEDKNOW PUBLICATIONS published article about ANTIOXIDANT; EXTRACT; GLUCOSE; METABOLISM in [Bouhrim, Mohamed; Ouassou, Hayat; Loukili, El Hassania; Ramdani, Mohammed; Mekhfi, Hassane; Ziyyat, Abderrahim; Legssyer, Abdelkhaleq; Aziz, Mohammed; Bnouham, Mohamed] Univ Mohamed First, Fac Sci, Oujda, Morocco in 2019, Cited 39. Quality Control of Anthrone. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8

Objective: To assess the antidiabetic effect of Opuntia dillenii seed oil on rats with diabetes mellitus. Methods: A rat diabetes model was established by intraperitoneal injection of rats with 50 mg/kg streptozotocin. Thirty albino Wistar rats were divided into five groups: the diabetic control group and normal control group were treated only with distilled water, two diabetic groups received 1 and 2 mL/kg of oil per day, respectively, for 30 days and one diabetic group received 2 mg/kg of glibenclamide. In addition, blood glucose was determined weekly. Body weight, average daily food, water intake and urinary volume of each animal were determined before and after the treatment period. After the treatment period, hepatic glycogen was determined using the anthrone reagent, and glycosuria, total cholesterol, triglycerides, alanine aminotransferase, aspartate aminotransferase, urea, creatinine and uric acid were estimated using common clinical diagnostic kits. Results: Oral intake of the oil at 1 and 2 mL/kg for the diabetic animals significantly diminished blood glucose, glycosuria, total cholesterol, triglycerides, alanine aminotransferase, aspartate aminotransferase, urea, creatinine and uric acid, accompanied by a noticeable elevation in the amount of hepatic glycogen in comparison with the diabetic control group. Similarly, Opuntia dillenii seed oil significantly increased the food intake and decreased the urinary volume per day in treated rats of the same groups in comparison with the period before the treatment intervention and attenuated body weight loss in the diabetic rats. Moreover, this effect of the oil was dose dependent. On the other hand, the oil did not affect their need for water. Conclusions: The results show that Opuntia dillenii seed oil has a very important antidiabetic effect on streptozotocin-induced diabetic rats. Hence, we suggest it as a preventive control of diabetes mellitus.

About Anthrone, If you have any questions, you can contact Bouhrim, M; Ouassou, H; Loukili, E; Ramdani, M; Mekhfi, H; Ziyyat, A; Legssyer, A; Aziz, M; Bnouham, M or concate me.. Quality Control of Anthrone

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2021 J CHROMATOGR A published article about SILICA; RETENTION; BEHAVIOR in [Moravcova, Dana; Cmelik, Richard; Krenkova, Jana] Czech Acad Sci, Inst Analyt Chem, Veveri 97, Brno 60200, Czech Republic in 2021, Cited 25. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Application In Synthesis of 2-Aminobenzamide

The advantages of using mixtures of organic solvents for the separation of labeled oligosaccharides on the amide stationary phase under hydrophilic interaction liquid chromatography conditions are presented. The effect of the type of buffer as well as solvent or their mixtures on retention of uracil, saccharide labeling reagents (2-aminobenzoic acid, 2-aminobenzamide, ethyl 4-aminobenzoate, procainamide), and corresponding labeled saccharides were evaluated. The successful isocratic separation of labeled isomeric trisaccharides (maltotriose, panose, and isomaltotriose) was achieved in the mobile phase consisting of a 90% (v/v) mixture of organic solvents (methanol/acetonitrile 60:40) and 10% (v/v) 30 mM ammonium formate, pH 3.3. Changing the volume ratio between methanol/acetonitrile from 60:40 to 50:50 (v/v) allowed to obtain the separation of di-, tri-, and tetrasaccharides labeled by ethyl 4-aminobenzoate in less than 10.5 min. (c) 2021 Elsevier B.V. All rights reserved.

Application In Synthesis of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Moravcova, D; Cmelik, R; Krenkova, J or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about SODIUM DIISOPROPYLAMIDE; TETRAHYDROFURAN SELECTIVITIES; CONJUGATE ADDITIONS; ARYL DERIVATIVES; ALKALI-METALS; STRONG BASES; VINYL; 2,2,6,6-TETRAMETHYLPIPERIDIDE; LITHIUM; ALKYL, Saw an article supported by the German Academic Scholarship Foundation; DFGGerman Research Foundation (DFG)European Commission; LMU; Projekt DEAL. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Harenberg, JH; Weidmann, N; Karaghiosoff, K; Knochel, P. The CAS is 119-61-9. Through research, I have a further understanding and discovery of Benzophenone. Application In Synthesis of Benzophenone

The sodiation of substituted acrylonitriles and alkenyl sulfides in a continuous flow set-up using NaDA (sodium diisopropylamide) in EtNMe2 or NaTMP (sodium 2,2,6,6-tetramethylpiperidide).TMEDA in n-hexane provides sodiated acrylonitriles and alkenyl sulfides, which are subsequently trapped in batch with various electrophiles such as aldehydes, ketones, disulfides and allylic bromides affording functionalized acrylonitriles and alkenyl sulfides. This flow-procedure was successfully extended to other acrylates by using Barbier-type conditions.

Application In Synthesis of Benzophenone. About Benzophenone, If you have any questions, you can contact Harenberg, JH; Weidmann, N; Karaghiosoff, K; Knochel, P or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 88-68-6. In 2020 CHEM PHARM BULL published article about CELL LUNG-CANCER; ACTIVATED PROTEIN-KINASE; EGFR INHIBITORS; RESISTANT; MUTATIONS; AZD9291; POTENT; DISCOVERY; AFATINIB; TKI in [Zhang, Mingguang; Wang, Yunyun; Li, Mingxin; Wang, Shifa] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Peoples R China; [Zhang, Mingguang; Wang, Jia; Liu, Zhaogang; Shi, Jingmiao; Zhu, Yongqiang] Jiangsu Chia Tai Fenghai Pharmaceut Co Ltd, 9 Weidi Rd, Nanjing 210046, Peoples R China; [Zhu, Yongqiang] Nanjing Normal Univ, Coll Life Sci, Nanjing 210046, Peoples R China in 2020, Cited 31. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Inhibition of the epidermal growth factor receptor (EGFR) has been proved to be one of the most promising strategies for the treatment of non-small cell lung cancers. A series of 2-aryl-4-amino substituted quinazoline derivatives were designed and synthesized with the purpose to overcome L858R/T790M/C797S (CTL) triple mutant drug resistance and the biological activity for inhibition of CTL kinases and EGFR wild type (WT) were evaluated. Three compounds (20, 24 and 27) showed excellent inhibitory activities against EGFR kinases triple mutant CTL (IC50 < 1 mu M) and high selectivity (IC50: WT/CTL >10000). Cell line evaluation showed that the most potent compound 27 was significantly potent against H1975-EGFR L858R/T790M (IC50 = 3.3 mu M) and H1975-EGFR L858R/T790M/C797S (IC50 = 1.2 mu M). Compound 27 also exhibited good microsomes stabilities in human, rat and mouse liver species, but low bioavailability. This work would be very useful for discovering new quinazoline derivatives as tyrosine kinase inhibitors targeting triple mutant L858R/T790M/C797S.

Product Details of 88-68-6. About 2-Aminobenzamide, If you have any questions, you can contact Zhang, MG; Wang, YY; Wang, J; Liu, ZG; Shi, JM; Li, MX; Zhu, YQ; Wang, SF or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem