Day: October 12, 2021

Authors Park, N; Jeon, J in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Park, Naree; Jeon, Junho] Changwon Natl Univ, Grad Sch FEED Ecofriendly Offshore Struct, Chang Won 51140, Gyeongsangnamdo, South Korea; [Jeon, Junho] Changwon Natl Univ, Sch Civil Environm & Chem Engn, Chang Won 51140, Gyeongsangnamdo, South Korea; [Jeon, Junho] Changwon Natl Univ, Dept Smart Ocean Environm Energy, Chang Won 51140, Gyeongsangnamdo, South Korea in 2021.0, Cited 68.0. Application In Synthesis of Benzophenone. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

The extensive development and use of new anthropogenic chemicals have inevitably led to their presence in aquatic environments. Surface waters affected by sewage effluents have been exposed to these new substances. In the present study, the occurrence of anthropogenic substances, including pharmaceuticals and industrial chemicals, was investigated in one of the major rivers in Korea, the Nakdong River. Furthermore, seasonal variations in their content were determined via annual monitoring. Through the suspect and non-target screening (SNTS) technique, 58 substances were newly identified in the river and integrated in the quantitative monitoring practice. The results revealed that niflumic acid and melamine exhibited the highest median concentrations, i.e., 320 ng/L and 11,000 ng/L, respectively. The results associated with seasonal change revealed that the concentration of a considerable number of substances increased in winter when the flow rate was low. Conversely, some substances exhibited high concentrations in summer (e.g., polyethylene glycol) and spring (e.g., niflumic acid). This was attributed to the seasonal changes in the consumption, prescriptions, or the application of alternative substances. These changes were also reflected by the risk quotient (RQ) values calculated from the concentration and toxicity values. Pharmaceuticals such as telmisartan and carbamazepine and industrial chemicals such as organophosphorus flame retardants (OPFRs) and melamine accounted for approximately 90% of the total RQ. Major substances prioritized using the production of the RQ value and the detection frequency included OPFRs and telmisartan. It is recommended that these results be reflected in future water quality monitoring plans. (C) 2020 Elsevier Ltd. All rights reserved.

Application In Synthesis of Benzophenone. About Benzophenone, If you have any questions, you can contact Park, N; Jeon, J or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Magnesium Halide-Catalyzed Synthesis of Oxaspiro[2.5]octenes from a Methylenecyclopropane and Acyl Cyanoalkenes WOS:000664252100009 published article about MGI2-MEDIATED RING EXPANSIONS; OXA-MICHAEL REACTION; CYCLOADDITION; LEWIS; ALKYLIDENECYCLOPROPANES; 2-METHYLENEAZIRIDINES; HETEROCYCLES; ANNULATION in [Suzuki, Itaru; Shibata, Ikuya] Osaka Univ, Res Ctr Environm Preservat, 2-4 Yamadaoka, Suita, Osaka 5650871, Japan; [Ogura, Kazuki; Shimazu, Jun-ya; Shibata, Ikuya] Osaka Univ, Dept Appl Chem, Grad Sch Engn, 2-1 Yamadaoka, Suita, Osaka 5650871, Japan in 2021, Cited 33. COA of Formula: C7H5NO3. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

MgX2-catalyzed annulation of methylenecyclopropanes with acyl cyanoalkenes was accomplished to give oxaspiro[2.5]octenes in excellent yields. The reaction proceeded through a rare intramolecular oxa-Michael addition of Mg enolate. The oxaspiro ring was transformed into 4H-pyran at a higher temperature in the presence of MgX2.

About 3-Nitrobenzaldehyde, If you have any questions, you can contact Suzuki, I; Ogura, K; Shimazu, J; Shibata, I or concate me.. COA of Formula: C7H5NO3

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Edrees, FH; Saad, AS; Alsaadi, MT; Amin, NH; Abdelwahab, NS in ROYAL SOC CHEMISTRY published article about GREEN SYNTHESIS STRATEGY; SPECTROPHOTOMETRIC DETERMINATION; SELECTIVE DETERMINATION; DOSAGE FORM; BENZOPHENONE; COMBINATION; METABOLITES; SUBSTANCES in [Edrees, Fadwa H.; Abdelwahab, Nada S.] Nanda Univ NUB, Fac Pharm, Pharmaceut Chem Dept, Bani Suwayf 62511, Egypt; [Saad, Ahmed S.] Cairo Univ, Analyt Chem Dept, Fac Pharm, Kasr El Aini St, Cairo 11562, Egypt; [Saad, Ahmed S.] Badr Univ Cairo BUC, Sch Pharm & Pharmaceut Ind, Pharmaceut Chem Dept, Cairo 11829, Egypt; [Alsaadi, Mohammed T.; Amin, Noha H.] Beni Suef Univ, Fac Pharm, Med Chem Dept, Bani Suwayf 62514, Egypt; [Alsaadi, Mohammed T.] Sinai Univ, Fac Pharm, Med Chem Dept, Kantra 45511, Egypt; [Abdelwahab, Nada S.] Beni Suef Univ, Pharmaceut Analyt Chem Dept, Fac Pharm, Bani Suwayf 62514, Egypt in 2021.0, Cited 48.0. Recommanded Product: 119-61-9. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

Recently, experimental design has beaten the traditional optimization approach (one variable at a time) by providing better quality for chromatographic separation using minimal effort and resources. Benzophenone (BZP) and [1-(diphenylmethyl)piperazine] (DPP) were reported to be the most toxic impurities for dimenhydrinate (DMH) and cinnarizine (CIN), respectively. Additionally, there is no reported HPLC method for the simultaneous determination of DMH, CIN and their toxic impurities. A custom experimental design was adopted to estimate the optimum conditions that achieved the most acceptable resolution with adequate peak symmetry within the shortest run time. Desirability function was used to define the optimum chromatographic conditions and the optimum separation was achieved using XBridge (R) HPLC RP-C18 (4.6 x 250 mm, 5 mu m), acetonitrile: 0.1% sodium lauryl sulphate (SLS) in water (90 : 10, v/v) as a mobile phase at flow rate 2 mL min(-1) and UV detection at 215 nm. Method validation was carried out according to ICH guidelines and linearity was achieved in the ranges of 2-25, 1-25, 1-12.5, and 1-12.5 mu g mL(-1) for DMH, CIN, BZP and DPP, respectively. By application of the proposed method to the market dosage form, no interference from excipients was observed. Moreover, the greenness of the method was evaluated using the National Environmental Method Index (NEMI), Analytical Eco-Scale and Green Analytical Procedure Index (GAPI) metrics and the results revealed the green environmental impact of the developed method.

Recommanded Product: 119-61-9. About Benzophenone, If you have any questions, you can contact Edrees, FH; Saad, AS; Alsaadi, MT; Amin, NH; Abdelwahab, NS or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Safety of 1-Phenylurea. Jabbour, SA; Frias, JP; Ahmed, A; Hardy, E; Choi, J; Sjostrom, CD; Guja, C in [Jabbour, Serge A.] Thomas Jefferson Univ, Philadelphia, PA 19107 USA; [Frias, Juan P.] Natl Res Inst, Los Angeles, CA USA; [Ahmed, Azazuddin] Apex Med Res, Chicago, IL USA; [Hardy, Elise] AstraZeneca, Gaithersburg, MD USA; [Choi, Jasmine] Statum Res, Irvine, CA USA; [Sjostrom, C. David] AstraZeneca, Gothenburg, Sweden; [Guja, Cristian] Carol Davila Univ Med & Pharm, Bucharest, Romania published Efficacy and Safety Over 2 Years of Exenatide Plus Dapagliflozin in the DURATION-8 Study: A Multicenter, Double-Blind, Phase 3, Randomized Controlled Trial in 2020.0, Cited 17.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

OBJECTIVE In patients with type 2 diabetes uncontrolled with metformin, exenatide once weekly (QW) plus dapagliflozin produced greater reductions in glycemic parameters (glycated hemoglobin [HbA(1c)], fasting plasma glucose [FPG], and 2-h postprandial glucose [2-h PPG]), weight, and systolic blood pressure (SBP) than exenatide QW or dapagliflozin alone after 28 weeks of treatment in DURATION-8. Following a 24-week extension period, improvements were sustained at 52 weeks. In this study, we investigated efficacy and safety at 104 weeks after randomization. RESEARCH DESIGN AND METHODS DURATION-8 was a 104-week, multicenter, double-blind, randomized, active-controlled, phase 3 trial. In total, 695 adults (aged >= 18 years) with type 2 diabetes and inadequate glycemic control (HbA(1c)8.0-12.0% [64-108 mmol/mol]) despite stable metformin monotherapy (>= 1,500 mg/day) were randomly assigned (1:1:1) to receive exenatide 2 mg QW plus once-daily dapagliflozin 10 mg, exenatide QW plus placebo, or dapagliflozin plus placebo. All 104-week evaluations were exploratory. RESULTS At week 104, 431 (62.0%) patients completed treatment. The adjusted least squares mean change (SE) from baseline to week 104 in HbA(1c)was greater with exenatide QW plus dapagliflozin (-1.70% [0.11]) versus exenatide QW plus placebo (-1.29% [0.12];P= 0.007) and dapagliflozin plus placebo (-1.06% [0.12];P< 0.001). Clinically relevant changes in FPG, 2-h PPG, weight, and SBP were also observed with exenatide QW plus dapagliflozin. There were no unexpected safety findings, and exenatide QW plus dapagliflozin was well tolerated, with no episodes of major hypoglycemia. CONCLUSIONS In this exploratory analysis, among those individuals who completed the trial without rescue therapy, there was clinically relevant efficacy over 2 years with exenatide QW plus dapagliflozin, with no unexpected safety findings. Safety of 1-Phenylurea. About 1-Phenylurea, If you have any questions, you can contact Jabbour, SA; Frias, JP; Ahmed, A; Hardy, E; Choi, J; Sjostrom, CD; Guja, C or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Stable and High-Strain Dielectric Elastomer Actuators Based on a Carbon Nanotube-Polymer Bilayer Electrode WOS:000602714100001 published article about BARRIER DISCHARGES in [Peng, Zihang; Shi, Ye; Chen, Norris; Li, Yanji; Pei, Qibing] Univ Calif Los Angeles, Henry Samueli Sch Engn & Appl Sci, Dept Mat Sci & Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA in 2021.0, Cited 53.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9. HPLC of Formula: C13H10O

Dielectric elastomer actuators (DEAs) have shown promises in numerous applications such as bio-inspired robotics, tactile displays, tunable optics, and microfluidics, owing to their unique combination of large actuation strain, high energy density, and light weight. However, the practical applications of the DEAs have been hindered partly due to their poor reliability and durability under high-strain actuation. A major failure mechanism is from the localized electrical breakdown. Compliant electrodes with self-clearing capability have been studied to prevent premature failures. Here, an interpenetrating bilayer compliant electrode comprising a thin layer of a water-based polyurethane (WPU) overcoated on an ultrathin single-walled carbon nanotube (SWNT) layer is reported. The thin polyurethane layer serves as the dielectric barrier to suppress corona discharges of the nanotubes in air. The SWNT+WPU bilayer electrode has the capability to self-clear at the breakdown sites, enhancing the fault tolerance and mendability of the DEA at a large-strain actuation. Stable actuation at 150% area strain for 1000 cycles under square-wave voltage and 5.5-h continuous actuation at a constant voltage have been achieved for acrylic elastomer-based DEAs.

About Benzophenone, If you have any questions, you can contact Peng, ZH; Shi, Y; Chen, N; Li, YJ; Pei, QB or concate me.. HPLC of Formula: C13H10O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Robust and efficient hydrogenation of carbonyl compounds catalysed by mixed donor Mn(I) pincer complexes WOS:000665625900009 published article about MANGANESE COMPLEXES; COORDINATION CHEMISTRY; LIGANDS; BEARING; AMINES; AMIDES; CYCLOTRIMERIZATION; (DE)HYDROGENATION; REACTIVITY; ALCOHOLS in [Yang, Wenjun; van Schendel, Robin K. A.; Filonenko, Georgy A.; Pidko, Evgeny A.] Delft Univ Technol, Fac Appl Sci, Dept Chem Engn, Inorgan Syst Engn Grp, Maasweg 9, NL-2629 HZ Delft, Netherlands; [Chernyshov, Ivan Yu] ITMO Univ, TheoMAT Grp, ChemBio Cluster, Lomonosova 9, St Petersburg 191002, Russia; [Weber, Manuela; Muller, Christian] Free Univ Berlin, Inst Chem & Biochem, Fabeckstr 34-36, D-14195 Berlin, Germany in 2021.0, Cited 48.0. COA of Formula: C13H10O. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

Any catalyst should be efficient and stable to be implemented in practice. This requirement is particularly valid for manganese hydrogenation catalysts. While representing a more sustainable alternative to conventional noble metal-based systems, manganese hydrogenation catalysts are prone to degrade under catalytic conditions once operation temperatures are high. Herein, we report a highly efficient Mn(I)-CNP pre-catalyst which gives rise to the excellent productivity (TOF degrees up to 41 000h(-1)) and stability (TON up to 200 000) in hydrogenation catalysis. This system enables near-quantitative hydrogenation of ketones, imines, aldehydes and formate esters at the catalyst loadings as low as 5-200 p.p.m. Our analysis points to the crucial role of the catalyst activation step for the catalytic performance and stability of the system. While conventional activation employing alkoxide bases can ultimately provide catalytically competent species under hydrogen atmosphere, activation of Mn(I) pre-catalyst with hydride donor promoters, e.g. KHBEt3, dramatically improves catalytic performance of the system and eliminates induction times associated with slow catalyst activation. Manganese-based hydrogenation catalysts are sensitive to high temperatures and may degrade under industrially relevant conditions. Here, the authors report a highly efficient manganese pincer pre-catalyst displaying high TOF values (up to 41 000 h(-1)) and stability (TON up to 200 000) at loadings as low as 5-200 ppm.

About Benzophenone, If you have any questions, you can contact Yang, WJ; Chernyshov, IY; van Schendel, RKA; Weber, M; Mueller, C; Filonenko, GA; Pidko, EA or concate me.. COA of Formula: C13H10O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Design, synthesis, and biological evaluation of quinazolin-4(3H)-one derivatives co-targeting poly(ADP-ribose) polymerase-1 and bromodomain containing protein 4 for breast cancer therapy published in 2021. Name: 2-Aminobenzamide, Reprint Addresses Liu, J; Liu, B; Ouyang, L (corresponding author), Sichuan Univ, West China Hosp, State Key Lab Biotherapy & Canc Ctr, Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

This study was aimed to design the first dual-target small-molecule inhibitor co-targeting poly (ADP-ribose) polymerase-1 (PARP1) and bromodomain containing protein 4 (BRD4), which had important cross relation in the global network of breast cancer, reflecting the synthetic lethal effect. A series of new BRD4 and PARP1 dual-target inhibitors were discovered and synthesized by fragment-based combinatorial screening and activity assays that together led to the chemical optimization. Among these compounds, 19d was selected and exhibited micromole enzymatic potencies against BRD4 and PARP1, respectively. Compound 19d was further shown to efficiently modulate the expression of BRD4 and PARP1. Subsequently, compound 19d was found to induce breast cancer cell apoptosis and stimulate cell cycle arrest at G1 phase. Following pharmacokinetic studies, compound 19d showed its antitumor activity in breast cancer susceptibility gene 1/2 (BRCA1/2) wild-type MDA-MB-468 and MCF-7 xenograft models without apparent toxicity and loss of body weight. These results together demonstrated that a highly potent dual-targeted inhibitor was successfully synthesized and indicated that co-targeting of BRD4 and PARP1 based on the concept of synthetic lethality would be a promising therapeutic strategy for breast cancer. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

Name: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Chang, XS; Sun, DJ; Shi, DF; Wang, G; Chen, YM; Zhang, K; Tan, HD; Liu, J; Liu, B; Ouyang, L or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Name: Benzophenone. Authors Yang, SS; Wang, XJ; Hu, ZQ; Guo, DC in ELSEVIER published article about in [Yang, Shuaishuai; Hu, Zhongqian; Guo, Dongcai] Hunan Univ, Coll Chem & Chem Engn, State Key Lab Chemobiosensing & Chemometr, Changsha 410082, Peoples R China; [Wang, Xingjing] Cardiff Univ, Cardiff Sch Chem, Cardiff CF10 3AT, Wales in 2021.0, Cited 47.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

The organic ligands with good coordination ability to Eu(III) ion attracted great attention, but the preparation of multifunctional organic ligands with excellent performance and the potential application was still a challenge in the field of rare earth coordination. In this work, a series of Schiff-base ligands and their corresponding Eu(III) complexes were successfully prepared. The ligands L1-4 exhibited typical AIE properties with various fluorescence emissions and high fluorescence quantum yields in an aggregated state. The luminescence intensity and luminescence lifetime of Eu(III) complexes were investigated by comparing different substituents of ligands. Density functional theory (DFT) calculations suggested that the electronegativity of the ligands L1-4 changed with the change of the substituents on the salicylaldehyde, which led to the phenomenon that the ligands exhibited diverse fluorescence emission from green to orange (maximum emission wavelengths were 525 nm, 546 nm 569 nm and 582 nm, respectively). All target Eu(III) complexes exhibited red luminescence of Eu(III) ions, accompanied by outstanding thermal stability and long luminescence lifetime. The effect of various substituent groups on luminescence intensity and luminescence lifetime of complexes was ordered: EuL3(Phen) (NO3)(3) > EuL2(Phen)(NO3)(3) > EuL1(Phen)(NO3)(3) > EuL4(Phen)(NO3)(3). Based on the above results, all ligands and corresponding target Eu(III) complexes had good application prospects in the field of optical materials.

About Benzophenone, If you have any questions, you can contact Yang, SS; Wang, XJ; Hu, ZQ; Guo, DC or concate me.. Name: Benzophenone

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Formula: C14H10O. I found the field of Chemistry very interesting. Saw the article Electrophilic Substitution of Asymmetrically Distorted Benzenes within Triptycene Derivatives published in 2021, Reprint Addresses Nishii, Y; Miura, M (corresponding author), Osaka Univ, Grad Sch Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan.. The CAS is 90-44-8. Through research, I have a further understanding and discovery of Anthrone.

Herein, we disclose a unique directing effect of 9-substituted triptycenes in electrophilic substitution to achieve the regioselective functionalization of the triptycene core. The Hirshfeld population analysis was adopted to predict the selectivity in electrophilic substitution. TMS and t-Bu groups were found to considerably accelerate the reaction at C2 positions to produce C3symmetric isomers. Correlation between distortion and charge distribution within benzene rings was systematically examined.

Formula: C14H10O. About Anthrone, If you have any questions, you can contact Ueno, K; Nishii, Y; Miura, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2021.0 ORG BIOMOL CHEM published article about IMINIUM ION CYCLIZATION; CARBONYL METATHESIS; O-ALKYNYLANILINES; CONSTRUCTION; BASICITY; HETEROCYCLES; ALDEHYDES; INDOLINE; RULES; WATER in [Amemiya, Sho; Okemoto, Shingo; Tsubouchi, Akira; Saito, Akio] Tokyo Univ Agr & Technol, Inst Engn, Div Appl Chem, 2-24-16 Araka Cho, Koganei, Tokyo 1848588, Japan in 2021.0, Cited 61.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6. Product Details of 99-61-6

We developed a synthetic method for alpha-(aminoethyl)-alpha,beta-enones from aryl-substituted homopropargyl sulfonamides and aldehydes, representing the first synthesis of conjugated enones via alkyne aza-Prins cyclization. These products could be converted into pyrrolidines by a formal 5-endo-trig cyclization.

About 3-Nitrobenzaldehyde, If you have any questions, you can contact Amemiya, S; Okemoto, S; Tsubouchi, A; Saito, A or concate me.. Product Details of 99-61-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem