Day: October 12, 2021

Name: Benzophenone. Authors Foubert, K; Dendooven, E; Theunis, M; Naessens, T; Ivanova, B; Pieters, L; Gilissen, L; Huygens, S; De Borggraeve, W; Lambert, J; Goossens, A; Aerts, O in WILEY published article about in [Foubert, Kenn; Dendooven, Ella; Theunis, Mart; Naessens, Tania; Ivanova, Boryana; Pieters, Luc] Univ Antwerp UA, Dept Pharmaceut Sci, Res Grp Nat Prod & Food Res & Anal NatuRA, Antwerp, Belgium; [Dendooven, Ella; Lambert, Julien; Aerts, Olivier] Univ Hosp Antwerp UZA, Dept Dermatol, Edegem, Belgium; [Dendooven, Ella; Lambert, Julien; Aerts, Olivier] Univ Antwerp, Res Grp Immunol, Infla Med Ctr Excellence, Antwerp, Belgium; [Gilissen, Liesbeth; Huygens, Sara; Goossens, An] Katholieke Univ Leuven, Dept Dermatol, Univ Hosp, Leuven, Belgium; [De Borggraeve, Wim] KU Leuven Chem&Tech, Dept Chem, Leuven, Belgium in 2021.0, Cited 27.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

Background: The reason why patients photosensitized to the drug ketoprofen (KP) may develop severe photoallergic skin reactions to octocrylene (OCT), an organic ultraviolet filter in sunscreens and cosmetics, remains largely unknown. OCT can be synthesized by using unsubstituted benzophenone (BP), a possible human carcinogen. Objectives: To verify if, and to what extent, BP residues are present in OCT-containing consumer products. Methods: The raw material of OCT and 39 skincare products, of which 28 contain OCT, were chemically analysed for the presence of BP by means of liquid chromatography. Results: In the OCT raw material and in all 28 OCT-containing products the presence of BP could be demonstrated, mostly in concentrations above 10 ppm (0.001%), whereas a majority of OCT-free products (8/11, 73%) did not contain BP. Moreover, BP concentrations significantly increased, in a time- and temperature-dependent manner, likely due to the additional degradation of OCT. Conclusion: Photoallergic contact dermatitis from OCT in patients photosensitized to KP might rely on residual BP impurities. Toxicological and ecological studies that evaluate the safety of OCT might also need to consider the concomitant presence of BP.

About Benzophenone, If you have any questions, you can contact Foubert, K; Dendooven, E; Theunis, M; Naessens, T; Ivanova, B; Pieters, L; Gilissen, L; Huygens, S; De Borggraeve, W; Lambert, J; Goossens, A; Aerts, O or concate me.. Name: Benzophenone

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: C13H10O. Authors Zhong, FY; Ma, MY; Zhong, ZR; Lin, XR; Chen, M in ROYAL SOC CHEMISTRY published article about in [Zhong, Fuyao; Lin, Xinrong] Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ,Yunnan Prov Ctr Res & Dev Nat Prod, Kunming 650091, Yunnan, Peoples R China; [Zhong, Fuyao; Ma, Mingyu; Zhong, Zhuoran; Chen, Mao] Fudan Univ, Dept Macromol Sci, State Key Lab Mol Engn Polymers, Shanghai 200433, Peoples R China in 2021.0, Cited 60.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

Along with high power capability and energy density, long cycle life is regarded an essential performance requirement for energy storage devices. The rapid capacitance decline of conducting polymer-based electrodes remains a major technical challenge and precludes their practical applications in supercapacitors. In this work, a polyaniline (PANI) network is synthesized via interfacial Buchwald-Hartwig polymerization for the first time, facilitating the construction of covalently connected PANI networks by ligand-promoted C-N bond formation. Particularly, the interfacial synthesis and subsequent gas release from pre-anchored protecting groups allow bottom-up and efficient access to porous cross-linked PANI (PCL-PANI) films that are free-standing and solvent-resistant. Upon assembling into supercapacitors, the PCL-PANI material enables an unprecedent long-term charge-discharge cycling performance (>18 000 times) without clear capacitance loss for an additive-free pseudocapacitive system. In addition, this synthesis affords electrodes entirely consisting of conducting polymers, yielding highly reversible gravimetric capacitance at 435 F g(electrode)(-1) in a two-electrode system, and a high gravimetric energy of 12.5 W h kg(electrode)(-1) while delivering an outstanding power density of 16 000 W kg(electrode)(-1), which is 10-fold higher than those of conventional linear PANI composite supercapacitors. This synthetic approach represents a novel and versatile strategy to generate additive/binder-free and high-performance conducting thin-films for energy storage.

About Benzophenone, If you have any questions, you can contact Zhong, FY; Ma, MY; Zhong, ZR; Lin, XR; Chen, M or concate me.. COA of Formula: C13H10O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Sulfur-Promoted Synthesis of 2-Aroylquinazolin-4(3H)-ones by Oxidative Condensation of Anthranilamide and Acetophenones WOS:000475925900008 published article about ONE-POT SYNTHESIS; ELEMENTAL SULFUR; REDOX CONDENSATION; QUINAZOLINE DERIVATIVES; O-AMINOBENZAMIDES; AMINES; KETONES; ACCESS; CYCLIZATION; INHIBITORS in [Thanh Binh Nguyen; Hou, Jing-ya; Retailleau, Pascal] Univ Paris Saclay, Inst Chim Subst Nat, CNRS, UPR 2301,Univ Paris Sud, 1 Ave Terrasse, F-91198 Gif Sur Yvette, France in 2019, Cited 50. Name: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A sulfur-promoted three-component reaction of isatoic anhydride, primary aliphatic or aromatic amines, and acetophenones leading to densely substituted 3-substituted 2-aroylquinazolin-4(3H)-ones is reported. The key step involves a cascade reaction of selective oxidation of the methyl group of the acetophenones, followed by a condensation with anthranilamides. The scope of the reaction is applicable to the synthesis of tryptanthrin and various 3-unsubstituted 2-aroylquinazolin-4(3H)-ones.

About 2-Aminobenzamide, If you have any questions, you can contact Nguyen, TB; Hou, JY; Retailleau, P or concate me.. Name: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: C7H8N2O. In 2019 EUR J MED CHEM published article about IN-VITRO; CANCER; QUINOXALINONES; EPIGENETICS; EXPRESSION; PHYSIOLOGY; ROLES in [Cheng, Chunhui; Yun, Fan; He, Jie; Ullah, Sadeeq; Yuan, Qipeng] Beijing Univ Chem Technol, Coll Life Sci & Technol, Minist Educ, Key Lab Biomed Mat Nat Macromol, 15 Beisanhuan East Rd, Beijing 100029, Peoples R China in 2019, Cited 43. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A series of novel 2-aminobenzamide derivatives decorated with thioquinazolinone were designed and synthesized as histone deacetylase (HDAC) inhibitors. These derivatives were evaluated for their anti-proliferative activities against several human cancer cell lines including A375, Hela, A549, HCT116 and SMMC7721. It’s significantly indicated that some inhibitors exhibited potent antiproliferative activities towards all the studied cancer cell lines. Compounds 7a, 4i, 4o, and 4p exhibited higher antiproliferative activities towards three cancer cell lines: A375, A549 and SMMC7721 compared to CS055, MS275, and C1994. Compound 4p showed more than 4000-fold the isoform selectivity for HDACI and more than 250-fold selectivity for HDAC2 compared with HDAC6. The molecular docking analysis reasonably explained the HDAC inhibitory activity and isoform selectivity. In addition, compounds 7a, 4i, 4o, and 4p showed potent inhibitory activities in migration assay and colony formation analysis, and also promoted cell apoptosis. Moreover, compounds 7a, 4i, and 4o inhibited the growth of SMMC7721 cells at S phase of the cell cycle. The immunofluorometric analysis indicated that compounds 7a, 4i, 4o, and 4p could increase the acetylation status of H3K9. Furthermore, in vivo anticancer efficacy of compound 4p was assessed in the A549 xenograft models, and 4p demonstrated potent antitumor activity (TGI = 62.5%). This study provided an effective strategy for further development of tumor-targeting therapy. (C) 2019 Elsevier Masson SAS. All rights reserved.

COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Cheng, CH; Yun, F; He, J; Ullah, S; Yuan, QP or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 64-10-8. In 2020.0 DIABETES CARE published article about TYPE-2 DIABETES-MELLITUS; ADD-ON THERAPY; SGLT2 INHIBITORS; TOLERABILITY; METFORMIN in [Jabbour, Serge A.] Thomas Jefferson Univ, Philadelphia, PA 19107 USA; [Frias, Juan P.] Natl Res Inst, Los Angeles, CA USA; [Ahmed, Azazuddin] Apex Med Res, Chicago, IL USA; [Hardy, Elise] AstraZeneca, Gaithersburg, MD USA; [Choi, Jasmine] Statum Res, Irvine, CA USA; [Sjostrom, C. David] AstraZeneca, Gothenburg, Sweden; [Guja, Cristian] Carol Davila Univ Med & Pharm, Bucharest, Romania in 2020.0, Cited 17.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

OBJECTIVE In patients with type 2 diabetes uncontrolled with metformin, exenatide once weekly (QW) plus dapagliflozin produced greater reductions in glycemic parameters (glycated hemoglobin [HbA(1c)], fasting plasma glucose [FPG], and 2-h postprandial glucose [2-h PPG]), weight, and systolic blood pressure (SBP) than exenatide QW or dapagliflozin alone after 28 weeks of treatment in DURATION-8. Following a 24-week extension period, improvements were sustained at 52 weeks. In this study, we investigated efficacy and safety at 104 weeks after randomization. RESEARCH DESIGN AND METHODS DURATION-8 was a 104-week, multicenter, double-blind, randomized, active-controlled, phase 3 trial. In total, 695 adults (aged >= 18 years) with type 2 diabetes and inadequate glycemic control (HbA(1c)8.0-12.0% [64-108 mmol/mol]) despite stable metformin monotherapy (>= 1,500 mg/day) were randomly assigned (1:1:1) to receive exenatide 2 mg QW plus once-daily dapagliflozin 10 mg, exenatide QW plus placebo, or dapagliflozin plus placebo. All 104-week evaluations were exploratory. RESULTS At week 104, 431 (62.0%) patients completed treatment. The adjusted least squares mean change (SE) from baseline to week 104 in HbA(1c)was greater with exenatide QW plus dapagliflozin (-1.70% [0.11]) versus exenatide QW plus placebo (-1.29% [0.12];P= 0.007) and dapagliflozin plus placebo (-1.06% [0.12];P< 0.001). Clinically relevant changes in FPG, 2-h PPG, weight, and SBP were also observed with exenatide QW plus dapagliflozin. There were no unexpected safety findings, and exenatide QW plus dapagliflozin was well tolerated, with no episodes of major hypoglycemia. CONCLUSIONS In this exploratory analysis, among those individuals who completed the trial without rescue therapy, there was clinically relevant efficacy over 2 years with exenatide QW plus dapagliflozin, with no unexpected safety findings. Product Details of 64-10-8. About 1-Phenylurea, If you have any questions, you can contact Jabbour, SA; Frias, JP; Ahmed, A; Hardy, E; Choi, J; Sjostrom, CD; Guja, C or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Triplet Excitons Quenching By Doublet Centers in a Nanoreactor with an External Magnetic Field WOS:000647943800009 published article about ELECTRON-SPIN POLARIZATION; PAIRS; MAGNETOCONDUCTANCE; RECOMBINATION; ANNIHILATION; RESONANCE; STATES in [Kucherenko, M. G.; Penkov, S. A.] Orenburg State Univ, Orenburg 460018, Russia in 2021.0, Cited 41.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9. Name: Benzophenone

The process of spin-selective quenching of a triplet (T) exciton by a fixed spin doublet (D) center in an organic semiconductor nanoparticle (anthracene, tetracene, MEH-PPV) was studied. Random walks of the T-exciton in a spherical nanovolume of a crystal or polymer globule were modeled based on the solution of the Neumann boundary diffusion condition. Time dependences of the spin-nonselective quenching rate of T-excitations were calculated for different values of geometric and diffusion parameters. Taking into account the spin dynamics of T-D-pair reagents allowed calculating magnetic field effects of T-D-quenching rate, which showed a strong influence of the nanoparticles size and initial position of the T-exciton and doublet sink on the absolute value of the effect. The obtained radial dependences of the magnetic field modulation of the quenching efficiency can be approximated by a superposition of two exponents.

Name: Benzophenone. About Benzophenone, If you have any questions, you can contact Kucherenko, MG; Penkov, SA or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Phosphomolybdic Acid (PMA)-catalyzed One-pot Synthesis of 2,3-Dihydroquinazolines WOS:000474370100005 published article about SOLVENT-FREE; CATALYST; EFFICIENT; 2,3-DIHYDRO-4(1H)-QUINAZOLINONES; QUINAZOLINONES; FACILE in [Chen, Chuanhuan; Xuejiao, A.; Li, Xia; Huang, Guoli; Liu, Bo] Yunnan Normal Univ, Sch Chem & Chem Engn, Kunming 650500, Yunnan, Peoples R China in 2019, Cited 34. Computed Properties of C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

We have developed a new method for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in good to excellent yields via phosphomolybdic acid (PMA)-catalyzed cyclocondensation of 2-aminobenzamides with aldehydes or ketones in N,N-dimethylformamide (DMF) at room temperature. The present method proves to be efficient in terms of short reaction time, high yield, simple workup and easy purification.

Computed Properties of C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Chen, CH; Xuejiao, A; Li, X; Huang, GL; Liu, B or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Liao, JN; Dong, JP; Xu, JQ; Wang, W; Wu, YJ; Hou, YX; Guo, HC in AMER CHEMICAL SOC published article about in [Liao, Jianning; Dong, Jipan; Xu, Jiaqing; Hou, Yuxia; Guo, Hongchao] China Agr Univ, Dept Chem, Beijing 100193, Peoples R China; [Wang, Wei; Wu, Yongjun] Zhengzhou Univ, Coll Publ Hlth, Zhengzhou 450001, Peoples R China in 2021.0, Cited 59.0. Recommanded Product: 3-Nitrobenzaldehyde. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

A phosphine-catalyzed [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford various multifunctional isoxazoles in moderate to good yields with moderate to excellent diastereoselectivities. With a spirocyclic chiral phosphine as the catalyst, up to 89% ee was obtained.

Recommanded Product: 3-Nitrobenzaldehyde. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Liao, JN; Dong, JP; Xu, JQ; Wang, W; Wu, YJ; Hou, YX; Guo, HC or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Dato, FM; Neudorfl, JM; Gutschow, M; Goldfuss, B; Pietsch, M in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about ACID-AMIDE HYDROLASE; MONOGLYCERIDE LIPASE; ENDOCANNABINOID SYSTEM; ACCURATE DOCKING; MAGL; DERIVATIVES; ANALOGS; GLIDE; IDENTIFICATION; PREDICTION in [Dato, Florian M.; Pietsch, Markus] Univ Cologne, Med Fac, Ctr Pharmacol, Inst Pharmacol 2, Gleueler Str 24, D-50931 Cologne, Germany; [Dato, Florian M.; Neudoerfl, Jorg-Martin; Goldfuss, Bernd] Univ Cologne, Inst Organ Chem, Dept Chem, Greinstr 4, D-50939 Cologne, Germany; [Guetschow, Michael] Univ Bonn, Pharmaceut Inst, Pharmaceut Chem 1, Immenburg 4, D-53121 Bonn, Germany in 2020, Cited 60. Name: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The serine hydrolase monoacylglycerol lipase (MAGL) is involved in a plethora of pathological conditions, in particular pain and inflammation, various types of cancer, metabolic, neurological and cardiovascular disorders, and is therefore a promising target for drug development. Although a large number of irreversible-acting MAGL inhibitors have been discovered over the past years, there are only few compounds known so far which inhibit the enzyme in a reversible manner. Therefore, much effort is put into the development of novel chemical entities showing reversible inhibitory behavior, which is thought to cause less undesired side effects. To explore a wide range of chemical structures as MAGL binders, we have applied a virtual screening approach by docking small molecules into the crystal structure of human MAGL (hMAGL) and envisaged a library of 45 selected compounds which were then synthesized. Biochemical investigations included the determination of the inhibitory potency on hMAGL and two related hydrolases, i.e. human fatty acid amide hydrolase (hFAAH) and murine cholesterol esterase (mCEase). The most promising candidates from theses analyses, i.e. three w-quinazolinonylalkyl aryl ureas bearing alkyl spacers of three to five methylene groups, exhibited IC50 values of 20-41 mu M and reversible, detergent-insensitive behavior towards hMAGL. Among these compounds, the inhibitor 1-(3,5-bis(tri-fluoromethyl)phenyl)-3-(4-(4-oxo-3,4 dihydroquinazolin-2-yl)butyl)urea (96) was selected for further kinetic characterization, yielding a dissociation constant K-i = 15.4 mu M and a mixed-type inhibition with a pronounced competitive component (alpha = 8.94). This mode of inhibition was further supported by a docking experiment, which suggested that the inhibitor occupies the substrate binding pocket of hMAGL.

About 2-Aminobenzamide, If you have any questions, you can contact Dato, FM; Neudorfl, JM; Gutschow, M; Goldfuss, B; Pietsch, M or concate me.. Name: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Velardo, A; Landi, A; Borrelli, R; Peluso, A in [Velardo, Amalia; Landi, Alessandro; Peluso, Andrea] Univ Salerno, Dipartimento Chim & Biol Adolfo Zambelli, I-84084 Fisciano, SA, Italy; [Borrelli, Raffaele] Univ Torino, Dept Agr Forestry & Food Sci, I-10195 Grugliasco, Italy; [Velardo, Amalia] Univ Torino, Dept Chem, I-10125 Turin, Italy published Reliable Predictions of Benzophenone Singlet-Triplet Transition Rates: A Second-Order Cumulant Approach in 2021.0, Cited 64.0. Category: thiomorpholine. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9.

Fermi golden rule and second-order cumulant expansion of the time-dependent density matrix have been used to compute from first principles the rate of intersystem crossing in benzophenone, using minimum-energy geometries and normal modes of vibrations computed at the TDDFT/CAM-B3LYP level. Both approaches yield reliable values of the S-1 decay rate, the latter being almost in quantitative agreement with the results of time-dependent spectroscopic measurements (0.154 ps(-1) observed vs 0.25 ps(-1) predicted). The Fermi golden rule slightly overestimates the decay rate of S-1 state (k(d) = 0.45 ps(-1)) but provides better insights into the chemico-physical parameters, which govern the transition from a thermally equilibrated population of S-1, showing that the indirect mechanism is much faster than the direct one because of the vanishingly small Franck-Condon weighted density of states at Delta E of transition.

Category: thiomorpholine. About Benzophenone, If you have any questions, you can contact Velardo, A; Landi, A; Borrelli, R; Peluso, A or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem