Authors Edrees, FH; Saad, AS; Alsaadi, MT; Amin, NH; Abdelwahab, NS in ROYAL SOC CHEMISTRY published article about GREEN SYNTHESIS STRATEGY; SPECTROPHOTOMETRIC DETERMINATION; SELECTIVE DETERMINATION; DOSAGE FORM; BENZOPHENONE; COMBINATION; METABOLITES; SUBSTANCES in [Edrees, Fadwa H.; Abdelwahab, Nada S.] Nanda Univ NUB, Fac Pharm, Pharmaceut Chem Dept, Bani Suwayf 62511, Egypt; [Saad, Ahmed S.] Cairo Univ, Analyt Chem Dept, Fac Pharm, Kasr El Aini St, Cairo 11562, Egypt; [Saad, Ahmed S.] Badr Univ Cairo BUC, Sch Pharm & Pharmaceut Ind, Pharmaceut Chem Dept, Cairo 11829, Egypt; [Alsaadi, Mohammed T.; Amin, Noha H.] Beni Suef Univ, Fac Pharm, Med Chem Dept, Bani Suwayf 62514, Egypt; [Alsaadi, Mohammed T.] Sinai Univ, Fac Pharm, Med Chem Dept, Kantra 45511, Egypt; [Abdelwahab, Nada S.] Beni Suef Univ, Pharmaceut Analyt Chem Dept, Fac Pharm, Bani Suwayf 62514, Egypt in 2021.0, Cited 48.0. Recommanded Product: 119-61-9. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9
Recently, experimental design has beaten the traditional optimization approach (one variable at a time) by providing better quality for chromatographic separation using minimal effort and resources. Benzophenone (BZP) and [1-(diphenylmethyl)piperazine] (DPP) were reported to be the most toxic impurities for dimenhydrinate (DMH) and cinnarizine (CIN), respectively. Additionally, there is no reported HPLC method for the simultaneous determination of DMH, CIN and their toxic impurities. A custom experimental design was adopted to estimate the optimum conditions that achieved the most acceptable resolution with adequate peak symmetry within the shortest run time. Desirability function was used to define the optimum chromatographic conditions and the optimum separation was achieved using XBridge (R) HPLC RP-C18 (4.6 x 250 mm, 5 mu m), acetonitrile: 0.1% sodium lauryl sulphate (SLS) in water (90 : 10, v/v) as a mobile phase at flow rate 2 mL min(-1) and UV detection at 215 nm. Method validation was carried out according to ICH guidelines and linearity was achieved in the ranges of 2-25, 1-25, 1-12.5, and 1-12.5 mu g mL(-1) for DMH, CIN, BZP and DPP, respectively. By application of the proposed method to the market dosage form, no interference from excipients was observed. Moreover, the greenness of the method was evaluated using the National Environmental Method Index (NEMI), Analytical Eco-Scale and Green Analytical Procedure Index (GAPI) metrics and the results revealed the green environmental impact of the developed method.
Recommanded Product: 119-61-9. About Benzophenone, If you have any questions, you can contact Edrees, FH; Saad, AS; Alsaadi, MT; Amin, NH; Abdelwahab, NS or concate me.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem