Day: October 13, 2021

Product Details of 119-61-9. Authors Tiessen, N; Kessler, M; Neumann, B; Stammler, HG; Hoge, B in WILEY-V C H VERLAG GMBH published article about in [Tiessen, Natalia; Kessler, Mira; Neumann, Beate; Stammler, Hans-Georg; Hoge, Berthold] Univ Bielefeld, Fak Chem, Ctr Mol Mat, Univ Str 25, D-33615 Bielefeld, Germany in 2021.0, Cited 73.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

According to a first view on the geometrical and electronic structure of the tris(pentafluoroethyl)silanide, this anion appears as a Lewis base. Quantum chemical calculations on perfluoroalkylated silanides show significantly lower HOMO and LUMO energy levels in comparison to their non-fluorinated counterparts, which implies reduced Lewis basicity and increased Lewis acidity of the [Si(C2F5)(3)](-) ion. With these findings and a HOMO-LUMO gap of 4.80 eV similar to N-heterocyclic silylenes (NHSis), perfluoroalkyl silanides are predestined to exhibit Lewis-amphoteric character similar to silylenes. Deprotonation of Si(C2F5)(3)H with sterically demanding phosphazene bases afforded thermally stable phosphazenium salts of the [Si(C2F5)(3)](-) anion, which add to benzaldehyde, benzophenone, CS2, and CO2 in various manners. This behavior also mirrors the reactivity of silylenes towards ketones as well as heterocumulenes and is rationalized by Lewis amphotericity being inherent in these silanides.

Product Details of 119-61-9. About Benzophenone, If you have any questions, you can contact Tiessen, N; Kessler, M; Neumann, B; Stammler, HG; Hoge, B or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: C14H10O. In 2020 MACROMOL CHEM PHYS published article about HEALING POLYMERIC MATERIALS; CROSS-LINKING; CYCLOREVERSION; FLUORESCENCE; DIELS in [He Zongke; Niu Hui; Li Yang] Dalian Univ Technol, State Key Lab Fine Chem, Liaoning Key Lab Polymer Sci & Engn, Dept Polymer Sci & Engn,Sch Chem Engn, Dalian 116024, Peoples R China in 2020, Cited 44. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8.

A series of pendant anthracene-functionalized ethylene/propylene copolymer rubbers (EPRs) with UV-light response and self-healing properties are prepared in this work. The reversible crosslinked networks are achieved based on the highly reversible nature of [4 + 4] cycloaddition of anthracene derivatives. The reversible crosslinking process is characterized by UV-vis spectrophotometer, which gives a high conversion yield of approximate to 90% as well as the reversibility of approximate to 70%. This reversible reaction is successfully applied to the self-healing of EPR material. The healing efficiency is evaluated quantitatively by tensile test measurement. In terms of stress at break, the healing efficiency of crosslinked EPR with anthracene content of 5.7 mol% can reach 82.9%. The anthracene-functionalized EPR might have a potential prospect of application in self-healing field.

COA of Formula: C14H10O. About Anthrone, If you have any questions, you can contact He, ZK; Niu, H; Li, Y or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2021.0 INT J NANOSCI published article about PEROXIDASE-LIKE ACTIVITY; HORSERADISH-PEROXIDASE; HIGHLY EFFICIENT; PERCHLORIC-ACID; NITRIC-OXIDE; OXIDATION in [Parthasarathy, Meera] Sree Vidyanikethan Engn Coll, Dept Basic Sci & Humanities, Tirupati 517102, Andhra Pradesh, India; [Adigopula, Srikanth; Gownivari, Harichandana; Mudhivedu, Gnanaprasanna; Vasudevan, Anitha; Ulaganadhan, Dhinakaran Sorakka] Sree Vidyanikethan Degree Coll, Dept Chem Sci, Tirupati 517102, Andhra Pradesh, India in 2021.0, Cited 26.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6. Formula: C7H5NO3

Nitration of aromatic compounds is an important industrial process, which creates significant environmental pollution because of the harsh mineral acid catalysts. In this work, we report the synthesis and application of magnetic iron oxide nanoparticles as green catalysts for aromatic nitration. Magnetic iron oxide nanoparticles were synthesized by co-precipitation method and tested for nitration reactions on selected aromatic substrates, phenol, benzaldehyde, methylbenzoate, o-cresol and p-cresol. For the nitration reactions, sodium nitrite was used as the nitro-source and hydrogen peroxide as the oxidant. Effect of reaction conditions like, solvent, temperature and microwave treatment were studied. The magnetic nanoparticles were found to be more stable after coating with a carbon shell by a one-pot carbonization method. The reactions were fast with good product yield under solvent-free microwave conditions. The nano-catalyst was recovered magnetically after the reaction and reused for three batches of nitration, without significant loss in catalytic activity. The nanoparticles were characterized using scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDAX), X-ray diffractometry (XRD) and FTIR spectroscopy.

Formula: C7H5NO3. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Parthasarathy, M; Adigopula, S; Gownivari, H; Mudhivedu, G; Vasudevan, A; Ulaganadhan, DS or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Electrochemical behavior study of some selected phenylurea herbicides at activated pencil graphite electrode. Electrooxidation of linuron and monolinuron WOS:000468714400137 published article about PERFORMANCE LIQUID-CHROMATOGRAPHY; VOLTAMMETRIC DETERMINATION; GAS-CHROMATOGRAPHY; CARBON; SAMPLES; WATER; SOIL; ADSORPTION; EXTRACTION; PESTICIDES in [Buleandra, Mihaela; Popa, Dana Elena; David, Iulia Gabriela; Bacalum, Elena; David, Victor; Ciucu, Anton Alexandru] Univ Bucharest, Dept Analyt Chem, Fac Chem, 90-92 Panduri Av, Bucharest 050663, Romania in 2019.0, Cited 45.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8. Name: 1-Phenylurea

A novel and rapid voltammetric assay for the simultaneous determination of monolinuron (MLN) and linuron (LIN) using an electrochemically pretreated pencil graphite electrode (PGE*) is reported for the first time. Enhanced oxidation peak currents of MLN and LIN were observed at PGE* when compared with electrochemically non-pretreated PGE. Differential pulse voltammetric (DPV) results showed distinct anodic peaks at 1.064 V and 1.170 V for MLN and LIN, respectively. Under optimum conditions, the detection limits were 3.7 x 10(-7) mol L-1 and 5.8 x 10(-7) mol L-1 for MLN and LIN respectively. The DPV method was applied for the quantitative determination of the mentioned compounds in spiked tap water samples enriched by solid phase extraction. The voltammetric results were in good agreement with high-performance liquid chromatography data.

Name: 1-Phenylurea. About 1-Phenylurea, If you have any questions, you can contact Buleandra, M; Popa, DE; David, IG; Bacalum, E; David, V; Ciucu, AA or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Synthesis of tricyclic quinazolinone-iminosugars as potential glycosidase inhibitors via a Mitsunobu reaction WOS:000468101000002 published article about PHARMACOLOGICAL CHAPERONES; DESIGN; AZASUGARS; ENZYMES in [Sun, Jiajing; Kang, Yaqing; Gao, Ligang; Lu, Xin; Ju, Huanhuan; Li, Xiaoliu; Chen, Hua] Hebei Univ, Coll Chem & Environm Sci, Key Lab Chem Biol Hebei Prov, Baoding 071002, Peoples R China in 2019, Cited 37. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Application In Synthesis of 2-Aminobenzamide

A series of novel tricyclic quinazolinone-iminosugars 1 (a-c) were synthesized from the benzyl protected sugars through three steps. Firstly, the benzyl protected sugar (aldehyde) 5 reacted with o-aminobenzamide by the iodine-induced oxidative condensation to afford the corresponding aldo-quizanolinone 6. Secondly, through the intramolecular cyclization of the unprotected OH and the amide NH in 6, the tricyclic compounds 7 and 8 were constructed by the key Mitsunobu reaction. Finally, removal of the benzyl group gave the target tricyclic quinazolinone-iminosugars 1. The protocol was effective for the preparation of the tricyclic iminosugars in satisfactory yield. Interestingly, an unusual C-2 epimerization was observed with D-mannose and D-ribose compounds under the conditions of the Mitsunobu reaction that generated the products having the trans configuration at the C-2 and C-3 positions. Unfortunately, such tricyclic quinazolinone-iminosugars showed no inhibitory effects on the tested five glycosidases.

About 2-Aminobenzamide, If you have any questions, you can contact Sun, JJ; Kang, YQ; Gao, LG; Lu, X; Ju, HH; Li, XL; Chen, H or concate me.. Application In Synthesis of 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Hsiao, YJ; Lin, LY in [Hsiao, Yu-Jui; Lin, Lu-Yin] Natl Taipei Univ Technol, Dept Chem Engn & Biotechnol, Taipei 10608, Taiwan; [Lin, Lu-Yin] Res Ctr Energy Conservat New Generat Residential, Taipei 10608, Taiwan published Enhanced Surface Area, Graphene Quantum Dots, and Functional Groups for the Simple Acid-Treated Carbon Fiber Electrode of Flexible Fiber-Type Solid-State Supercapacitors without Active Materials in 2020.0, Cited 35.0. Name: 1-Phenylurea. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

Flexible fiber-type solid-state supercapacitors (FSCs) are demanded for energy storage of wearable soft electronics. A flexible carbon fiber (CF) with high electrical conductivity and good energy storage ability can act as the current collector and the active material simultaneously. Improving the energy storage ability of the CF without depositing active materials is highly promising to avoid active materials from peeling off, especially under bending conditions. In this study, the CF is treated with acid mixtures containing different HNO3 to H2SO4 ratios. The roughened surface and the production of graphene quantum dots and functional groups are achieved for the acid-treated CF, especially for the CF treated with the acid mixtures. The largely enhanced specific capacitance (C-L) is first obtained for the optimized CF electrode (641.08 mF/cm at 5 mV/s) treated with the acid mixture containing the HNO3 to H2SO4 ratio of 1 to 3. The FSC also shows a maximum energy density of 16.57 mu W h/cm at the power density of 62.50 mu W/cm, as well as a C-L retention of 77% and Coulombic efficiency of 100% in 5000 times of a charge/discharge cycling process. Excellent flexibility is also attained for the FSC with no shape distortion of cyclic voltammetry curves measured under the bending angle of 180 degrees and with 1000 times of repeated bending. This work proposes a simple acid treatment to largely enhance the energy storage ability of pure CF electrodes. The bifunctional substance with current collecting and energy storing abilities is expected to be well developed in the future for applying on numerous efficient flexible energy storage devices.

About 1-Phenylurea, If you have any questions, you can contact Hsiao, YJ; Lin, LY or concate me.. Name: 1-Phenylurea

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 2-Aminobenzamide. Recently I am researching about PHOSPHONEUROFILAMENT HEAVY-CHAIN; IMMUNOGLOBULIN-G; FC; ANTIBODIES; DIAGNOSIS; GLYCANS; NEUROINFLAMMATION; GALACTOSYLATION; NEUROFILAMENTS; ASSOCIATION, Saw an article supported by the EU JPND project SOPHIA, Fundacao para a Ciencia e a Tecnologia (FCT) [JPND/0003/2011]; Portugal and Euronanomed 2 ERA-NET project GlioEx, FCT, Portugal [ENMed/0001/2013]; iNOVA4Health Research Unit [LISBOA-01-0145-FEDER-007344]; FCT/Ministerio da Ciencia e do Ensino Superior; FEDER under the PT2020 Partnership Agreement. Published in SPRINGER in NEW YORK ,Authors: Costa, J; Streich, L; Pinto, S; Pronto-Laborinho, A; Nimtz, M; Conradt, HS; de Carvalho, M. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease for which the existing candidate biomarkers (neurofilaments) have low specificity. Changes in blood IgG N-glycosylation have been observed in several diseases, including ALS, whereas cerebrospinal fluid (CSF) IgG has been less studied. Here, we characterized N-glycans of CSF IgG from ALS patients in comparison with a control group of other neurological diseases. Cerebrospinal fluid was collected from patients with ALS (n=26) and other neurological diseases (n=10). N-Glycans were released from CSF purified IgG with peptide N-glycosidase F, labeled with 2-aminobenzamide and analyzed by NP-HPLC chromatography in combination with exoglycosidase digestion and MALDI-TOF mass spectrometry. The N-glycosylation profile of ALS CSF IgG consisted of diantennary N-glycans predominantly with proximal fucose and some bisecting GlcNAc; agalacto-, mono-, and digalactosylated as well as alpha 2,6-sialylated structures were detected. Differences between ALS and control patients were observed; most relevant was the increase in ALS CSF IgG of the level of galactosylated structures defined here as Gal-index (median 46.87 and 40.50% for ALS and controls, respectively; p=0.006). The predictive value of the Gal-index (AUC=0.792, p=0.007) considering ROC analysis had potential utility as a diagnostic test for ALS and was comparable to that of phosphoneurofilament heavy chain (AUC=0.777, p=0.011), which was used as benchmark marker for our group of patients. The results provide the basis to further explore the potential of IgG N-glycan galactosylation as biomarker for ALS by using larger cohorts of patients and controls.

Recommanded Product: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Costa, J; Streich, L; Pinto, S; Pronto-Laborinho, A; Nimtz, M; Conradt, HS; de Carvalho, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Mohammadi, AA; Taheri, S; Ghaderi, P; Ahdenov, R; Azizian, H; Mohammadi-Khanaposhtani, M; Faramarzi, MA; Larijani, B; Mahdavi, M in [Mohammadi, Ali Asghar; Taheri, Salman; Ghaderi, Peghman; Ahdenov, Reza] Dept Chem & Chem Engn, Res Ctr Iran, POB 14115-175, Tehran, Iran; [Azizian, Homa] Iran Univ Med Sci, Dept Med Chem, Sch Pharm, Int Campus, Tehran, Iran; [Mohammadi-Khanaposhtani, Maryam] Babol Univ Med Sci, Cellular & Mol Biol Res Ctr, Hlth Res Inst, Babol, Iran; [Faramarzi, Mohammad Ali] Univ Tehran Med Sci, Fac Pharm & Biotechnol Res Ctr, Dept Pharmaceut Biotechnol, Tehran, Iran; [Larijani, Bagher; Mahdavi, Mohammad] Univ Tehran Med Sci, Endocrinol & Metab Res Ctr, Endocrinol & Metab Clin Sci Inst, Tehran, Iran published Synthesis of the new tri-amide derivatives as novel alpha-glucosidase inhibitors by Ugi four-component reaction in 2021, Cited 30. HPLC of Formula: C7H5NO3. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6.

In this study, new tri-amides 5a-1 have been synthesized via a one-pot four-component Ugi reaction between repaglinide, aniline derivatives, aldehyde derivatives, and cyclohexyl isocyanide in good yields. These compounds were evaluated against yeast alpha-glucosidase. Obtained in vitro alpha-glucosidase results demonstrated that all the synthesized compounds 5a-1 were more potent than standard inhibitor acarbose. Among them, the most potent compounds were compounds 5j, 5k, and 5h. The kinetic analysis of the most potent compound 5j revealed that this compound is a competitive inhibitor for alpha-glucosidase (K-i = 24 mu M). Furthermore, docking study of the most potent compounds was also performed in the alpha-glucosidase active site to find interaction modes and binding energies of these compounds. (C) 2020 Elsevier B.V. All rights reserved.

HPLC of Formula: C7H5NO3. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Mohammadi, AA; Taheri, S; Ghaderi, P; Ahdenov, R; Azizian, H; Mohammadi-Khanaposhtani, M; Faramarzi, MA; Larijani, B; Mahdavi, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Comparative Genomics Suggests Mechanisms of Gene is Adaptation toward the Catabolism of the Phenylurea Herbicide Linuron in Variovorax WOS:000552380600007 published article about 2,4-DICHLOROPHENOXYACETIC ACID; NUCLEOTIDE-SEQUENCE; INCP-1-BETA PLASMIDS; BACTERIAL CONSORTIUM; METABOLIC PATHWAY; DEGRADATION; RESISTANCE; TRANSPOSON; DIVERSITY; EVOLUTION in [Ozturk, Basak] Leibniz Inst DSMZ, German Collect Microorganisms & Cell Cultures, Jr Res Grp Microbial Biotechnol, Braunschweig, Germany; [Ozturk, Basak; Springael, Dirk] Katholieke Univ Leuven, Div Soil & Water Management, Leuven, Belgium; [Werner, Johannes] Leibniz Inst Baltic Sea Res, Dept Biol Oceanog, Rostock, Germany; [Meier-Kolthoff, Jan P.; Bunk, Boyke; Sproer, Cathrin] Leibniz Inst DSMZ, Dept Bioinformat & Databases, German Collect Microorganisms & Cell Cultures, Braunschweig, Germany in 2020.0, Cited 84.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8. Application In Synthesis of 1-Phenylurea

Biodegradation of the phenylurea herbicide linuron appears a specialization within a specific Glade of the Variovorax genus. The linuron catabolic ability is likely acquired by horizontal gene transfer but the mechanisms involved are not known. The full-genome sequences of six linuron-degrading Variovorax strains isolated from geographically distant locations were analyzed to acquire insight into the mechanisms of genetic adaptation toward linuron metabolism. Whole-genome sequence analysis confirmed the phylogenetic position of the linuron degraders in a separate Glade within Variovorax and indicated that they unlikely originate from a common ancestral linuron degrader. The linuron degraders differentiated from Variovorax strains that do not degrade linuron by the presence of multiple plasmids of 20-839 kb, including plasmids of unknown plasmid groups. The linuron catabolic gene clusters showed 1) high conservation and synteny and 2) strain-dependent distribution among the different plasmids. Most of them were bordered by IS1071 elements forming composite transposon structures, often in a multimeric array configuration, appointing IS1071 as a key element in the recruitment of linuron catabolic genes in Variovorax. Most of the strains carried at least one (catabolic) broad host range plasmid that might have been a second instrument for catabolic gene acquisition. We conclude that Glade 1 Variovorax strains, despite their different geographical origin, made use of a limited genetic repertoire regarding both catabolic functions and vehicles to acquire linuron biodegradation.

Application In Synthesis of 1-Phenylurea. About 1-Phenylurea, If you have any questions, you can contact Ozturk, B; Werner, J; Meier-Kolthoff, JP; Bunk, B; Sproer, C; Springael, D or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Sonawane, V; Siddique, MUM; Jadav, SS; Sinha, BN; Jayaprakash, V; Chaudhuri, B in [Sonawane, Vinay; Chaudhuri, Bhabatosh] De Montfort Univ, Leicester Sch Pharm, Leicester LE1 9BH, Leics, England; [Siddique, Mohd Usman Mohd; Sinha, Barij Nayan; Jayaprakash, Venkatesan] Birla Inst Technol, Dept Pharmaceut Sci & Technol, Ranchi 835215, Bihar, India; [Jadav, Surender Singh] Indian Inst Chem Technol, CSIR, Hyderabad 500007, Telangana, India published Cink4T, a quinazolinone-based dual inhibitor of Cdk4 and tubulin polymerization, identified via ligand-based virtual screening, for efficient anticancer therapy in 2019, Cited 79. Category: thiomorpholine. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Inhibition of cyclin dependent kinase 4 (Cdk4) prevents cancer cells from entering the early G(0)/G(1) phase of the cell division cycle whereas inhibiting tubulin polymerization blocks cancer cells’ ability to undergo mitosis (M) late in the cell cycle. We had reported earlier that two non-planar and relatively non-toxic fascaplysin derivatives, an indole and a tryptoline, inhibit Cdk4 with IC50 values of 6.2 and 10 mu M, respectively. Serendipitously, we had also found that they inhibited tubulin polymerization. The molecules were efficacious in mouse tumor models. We have now identified Cink4T in a 59-compound quinazolinone library, designed on the basis of ligand-based virtual screening, as a compound that inhibits Cdk4 and tubulin. Its IC50 value for Cdk4 inhibition is 0.47 mu M and >50 mu M for inhibition of Cdk1, Cdk2, Cdk6, Cdk9. Cink4T inhibits tubulin polymerization with an IC50 of 0.6 mu M. Molecular modelling studies on Cink4T with Cdk4 and tubulin crystal structures lend support to these observations. Cancer cell cycle analyses confirm that Cink4T blocks cells at both G(0)/G(1) and M phases as it should if it were to inhibit both Cdk4 and tubulin polymerization. Our results show, for the very first time, that virtual screening can be used to design novel inhibitors that can potently block two crucial phases of the cell division cycle. (C) 2019 Elsevier Masson SAS. All rights reserved.

Category: thiomorpholine. About 2-Aminobenzamide, If you have any questions, you can contact Sonawane, V; Siddique, MUM; Jadav, SS; Sinha, BN; Jayaprakash, V; Chaudhuri, B or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem