COA of Formula: C7H8N2O. Venkatesh, R; Kasaboina, S; Jain, N; Janardhan, S; Holagunda, UD; Nagarapu, L in [Venkatesh, Ramineni; Kasaboina, Suresh; Holagunda, Uma Devi; Nagarapu, Lingaiah] CSIR Indian Inst Chem Technol, Fluoro Agrochem Div 2, Hyderabad 500007, India; [Jain, Nishant] CSIR Indian Inst Chem Technol, Ctr Chem Biol, Hyderabad 500007, India; [Janardhan, Sridhara] CSIR Indian Inst Chem Technol, Ctr Mol Modeling, Hyderabad 500007, India published Design and synthesis of novel sulphamide tethered quinazolinone hybrids as potential antitumor agents in 2019, Cited 41. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.
In an attempt to develop potential and selective antitumor agents, a series of novel sulphamide tethered quinazolinone hybrids were efficiently synthesized and evaluated for antitumor activity against four cancer cell lines such as HeLa (cervical), MDA-MB-231 (breast), PANC-1 (pancreatic), and A549 (lung) in vitro. All the compounds (5a-j, 6a-g) exhibited significant anti-proliferative activity with GI(50) values ranging from 0.045 to 6.94 mu M, while compound 10c showed potent activity against all the cell lines (He La, MDA-MB-231, PANC-1 and A549) with GI(50) values ranging from 0.09 to 0.21 mu M. We have explored the binding mode and key active site interactions in HDAC8 and EHMT2 proteins. The docking results are complementary to the experimental results. (C) 2019 Elsevier B.V. All rights reserved.
COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Venkatesh, R; Kasaboina, S; Jain, N; Janardhan, S; Holagunda, UD; Nagarapu, L or concate me.
Reference:
Thiomorpholine – Wikipedia,
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