An update on the compound challenge: C14H10O

Formula: C14H10O. About Anthrone, If you have any questions, you can contact Richards, C; O’Connor, N; Jose, D; Barrett, A; Regan, F or concate me.

Formula: C14H10O. Authors Richards, C; O’Connor, N; Jose, D; Barrett, A; Regan, F in ROYAL SOC CHEMISTRY published article about in [Richards, Chloe; O’Connor, Nicole; Jose, Diveena; Barrett, Alan; Regan, Fiona] Dublin City Univ, DCU Water Inst, Sch Chem Sci, Dublin 9, Ireland in 2020, Cited 19. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8

Biological fouling, also called biofouling, is the undesirable formation of organisms on a surface immersed in water. When the exterior surface of an object such as a vessel is submerged in seawater for a prolonged period, micro and macro organisms usually accumulate on the surface. Biofilms are a set of microorganisms attached to a surface through exopolymers they produce, also known as extracellular polymeric substances (EPS). EPS are a mixture of polymers produced by microorganisms such as bacteria in the presence of biomass. EPS are mainly made up of carbohydrates and proteins, but in smaller quantities, they also contain lipids, nucleic acids, and humic substances. Proteins and carbohydrates found in eps can be quantified by using biochemical methods. The Modified Lowry method, BCA method, and Bradford methods are the common biochemical methods used to quantify protein. Anthrone-sulphuric acid and phenol-sulphuric acid are most common methods used to quantify carbohydrate. The Lowry method was determined to be the best method to quantify protein because it has high precision, low error and low limit of detection. Also, it is highly sensitive and reproducible. The anthrone method was determined to be the best method to quantify carbohydrate because it has high precision, low error, low LOQ. Results were confirmed by testing on substrates deployed in the marine environment to allow establishment of a natural biofilm for study.

Formula: C14H10O. About Anthrone, If you have any questions, you can contact Richards, C; O’Connor, N; Jose, D; Barrett, A; Regan, F or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

 

Now Is The Time For You To Know The Truth About Anthrone

HPLC of Formula: C14H10O. About Anthrone, If you have any questions, you can contact Gao, P; Xu, M; Liu, YL; da Silva, EB; Xiang, P; Ma, LNQ or concate me.

HPLC of Formula: C14H10O. In 2019 SCI TOTAL ENVIRON published article about POLYCYCLIC AROMATIC-HYDROCARBONS; BACKGROUND CONCENTRATIONS; BIOACCESSIBILITY; EXPOSURE; SURFACE in [Gao, Peng; da Silva, Evandro B.; Xiang, Ping; Ma, Lena Q.] Southwest Forestry Univ, Inst Environm Remediat & Human Hlth, Kunming 650224, Yunnan, Peoples R China; [Gao, Peng; Xu, Min; da Silva, Evandro B.; Ma, Lena Q.] Univ Florida, Soil & Water Sci Dept, Gainesville, FL 32611 USA; [Xu, Min] Sichuan Agr Univ, Coll Environm Sci, Chengdu 611130, Sichuan, Peoples R China; [Liu, Yalan] Univ Florida, Dept Environm Engn Sci, Gainesville, FL 32611 USA in 2019, Cited 20. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8.

Polycyclic aromatic hydrocarbons (PAHs) are widespread organic contaminants in the environment, much being accumulated in soils. Although their concentrations in large cities have been studied, their levels in small cities were less studied. This study determined the concentrations, distributions, and sources of 16 USEPA priority PAHs (legacy PAHs) and 6 emerging PAHs in urban soils of four small cities. A total of 100 soil samples were collected in Florida, USA. The average Sigma 16-PAHs in urban soils of Clay county, Ocala, Pensacola, and West Palm Beach were 1821, 2748, 3115 and 4055 mu g kg(-1), respectively. Based on benzo[a]pyrene-equivalent (BaP-EQ), the 7 USEPA carcinogenic PAHs (7cPAHs) and 3 emerging carcinogenic PAHs (3cPAHs) in urban soils in Clay County averaged 223 and 3703, Ocala 319 and 4521, Pensacola 302 and 5423, and West Palm Beach 449 and 5916 mu g kg(-1), respectively. Although Sigma 7cPAHs in 87-89% of samples were lower than the Florida Soil Cleanup Target Levels (FSCTLs) for industrial sites at 700 mu g kg(-1), Sigma 3cPAHs were 13-18 times greater than Sigma 7cPAHs. Based on the PMF model and molecular diagnostic ratios, soil PAHs were dominated by similar sources in small cities, mainly from pyrogenic sources including biomass, coal and coke combustion and vehicle emissions. It is important to evaluate both legacy and emerging PAHs concentrations in urban soils when considering soil remediation and human health risk assessment. (C) 2019 Published by Elsevier B.V.

HPLC of Formula: C14H10O. About Anthrone, If you have any questions, you can contact Gao, P; Xu, M; Liu, YL; da Silva, EB; Xiang, P; Ma, LNQ or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

 

The Absolute Best Science Experiment for C7H5NO3

Recommanded Product: 99-61-6. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Kopf, S; Neumann, H; Beller, M or concate me.

An article Manganese-catalyzed selective C-H activation and deuteration by means of a catalytic transient directing group strategy WOS:000613880600013 published article about H/D EXCHANGE; FUNCTIONALIZATION; OLEFINS in [Kopf, Sara; Neumann, Helfried; Beller, Matthias] Leibniz Inst Katalyse, Albert Einstein Str 29a, D-18059 Rostock, Germany in 2021, Cited 43. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6. Recommanded Product: 99-61-6

A novel manganese-catalyzed C-H activation methodology for selective hydrogen isotope exchange of benzaldehydes is presented. Using D2O as a cheap and convenient source of deuterium, the reaction proceeds with excellent functional group tolerance. High ortho-selectivity is achieved in the presence of catalytic amounts of specific amines, which in situ form a transient directing group.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

 

The Best Chemistry compound:C14H10O

Recommanded Product: Anthrone. About Anthrone, If you have any questions, you can contact Hosseini, A; Schreiner, PR or concate me.

Authors Hosseini, A; Schreiner, PR in WILEY-V C H VERLAG GMBH published article about ONE-POT SYNTHESIS; ARYL HALIDES; DERIVATIVES; ALCOHOLS; FLUORIDE; MECHANOCHEMISTRY; NANOPARTICLES; HYDROCARBONS; ACTIVATION; VINYLATION in [Hosseini, Abolfazl; Schreiner, Peter R.] Justus Liebig Univ Giessen, Inst Organ Chem, Heinrich Buff Ring 17, D-35392 Giessen, Germany in 2020, Cited 71. Recommanded Product: Anthrone. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8

Ball milling of calcium carbide (CaC2) enables the reaction of its ethynyl moiety with organic electrophiles. This was realized simply by co-milling CaC(2)with organic substrates in a sealed jar without the need for an additive or a catalyst. Various ketones including those bearing alpha-hydrogens were ethynylated in good yields at short reaction times. Aryl halides are also amenable substrates for this protocol as they furnish aryl ethynes through a benzyne intermediate. This method offers a practical and cheap alternative to the established procedures for introducing ethynyl functionalities.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

 

Simple exploration of 1-Phenylurea

About 1-Phenylurea, If you have any questions, you can contact Sun, ZZ; Jiang, YB; Zeng, L; Huang, LM or concate me.. Name: 1-Phenylurea

An article Intramolecular Charge Transfer and Extended Conjugate Effects in Donor–Acceptor-Type Mesoporous Carbon Nitride for Photocatalytic Hydrogen Evolution WOS:000467235500005 published article about POLYMERIC PHOTOCATALYST; H-2 PRODUCTION; ORGANIC-DYES; NANOSHEETS; G-C3N4; WATER; SEMICONDUCTORS; ABSORPTION; CONSTRUCTION; FLUORINATION in [Sun, Zongzhao] Harbin Inst Technol, Sch Chem & Chem Engn, Harbin 150001, Heilongjiang, Peoples R China; [Sun, Zongzhao; Jiang, Yabin; Zeng, Lei; Huang, Limin] Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China in 2019.0, Cited 80.0. Name: 1-Phenylurea. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

Inspired by donor-acceptor (D-A) polymers in organic solar cell and the extended conjugation effect, a conceptual design of D–A-type mesoporous carbon nitride with benzene or thiophene as a -spacer is proposed as an efficient photocatalyst for hydrogen evolution. The photocatalyst was successfully synthesized by a one-pot thermopolymerization based on nucleophilic substitution and a Schiff-base chemical reaction. On the molecular level, the insertion of an in-plane benzene as a -spacer by forming covalent bonds C=N (acceptor) and C-N (donor) interrupts the continuity of tri-s-triazine units and maintains the intrinsic – conjugated electronic system. Synchronously, the enlarged electron delocalization and the intramolecular charge transfer induced by polarization provide force-directed migration of electrons, leading to boosted optical absorption capability and enhanced photogenerated carrier separation. With the synergistic effects of the mesoporous structure and excellent optical and electronic properties, a fivefold increase in the H-2 evolution rate compared with that of pristine g-C3N4 was achieved with robust performance. In addition, other simple aromatic heterocyclic compounds (e.g., pyridine, thiophene and furan)-based D–A structures with a higher hydrogen evolution rate (up to sevenfold increase) were also explored to broaden the application for the design of novel photocatalysts.

About 1-Phenylurea, If you have any questions, you can contact Sun, ZZ; Jiang, YB; Zeng, L; Huang, LM or concate me.. Name: 1-Phenylurea

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

 

The important role of C14H10O

About Anthrone, If you have any questions, you can contact Ovchinnikov, MY; Antipin, VA; Khursan, SL or concate me.. Computed Properties of C14H10O

An article Thermostimulated luminescence of poly(diphenylenephthalide) films. Kinetics and mechanistic steps of irradiative processes WOS:000501355900027 published article about BASIS-SET; PHTHALIDE); POLYMERS; THERMOLUMINESCENCE; MODEL; ELECTROLUMINESCENCE in [Ovchinnikov, Mikhail Yu; Antipin, Vyacheslav A.; Khursan, Sergey L.] Ufa Inst Chem UFRC RAS, 71 Prospect Oktyabrya, Ufa 450054, Russia in 2020, Cited 59. Computed Properties of C14H10O. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8

Kinetics of thermostimulated luminescence (TSL) of poly(diphenylenephthalide) (PDPh) films has been studied using mathematical modelling and DFT approximation. TSL of PDPh-film was considered to be arising from irradiative deactivation of diphenylene (DP) fragment of polymer chain in excited state formed upon recombination of the spatial separated ion-radical pairs generated by photoexcitation. Two parallel monomolecular transformations leading to excited DP have been revealed: the first path is characterized by the activation parameters of the kinetic rate constant k1 which equal to Al ti 105 sec 1 and Eat ti 70 kJ mol(-1). This path may be interpreted in terms of mechanical relaxation theory by segmental polymer mobility as electron transfer (ET) from phthalide (Ph) anion-to DP cation-radical. The second channel is supposed to be consist of two consecutive ET from triarylmethyl anion-radical to phthalide neutral (A2 ti 1 sec 1, Ea2 ti 20 kJ mol(-1)), and then to DP cation-radical (A3 N 104 sec 1, E,3 N 40 kJ mol(-1)) of the polymer chain indicating y- and fl-relaxation, respectively. The revealed mechanistic steps and electron retention efficiency estimated in B97-2/6-311 + G(d,p) approximation for the most probable anion-radicals may point out the key role of domino quantum tunneling in transfer and recombination of charges in PDPh films.

About Anthrone, If you have any questions, you can contact Ovchinnikov, MY; Antipin, VA; Khursan, SL or concate me.. Computed Properties of C14H10O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

 

An overview of features, applications of compound:C7H5NO3

Recommanded Product: 3-Nitrobenzaldehyde. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Tabassum, R; Ashfaq, M; Oku, H or concate me.

Authors Tabassum, R; Ashfaq, M; Oku, H in WILEY published article about QUINOLINE DERIVATIVES; BIOLOGICAL EVALUATION; MALDI-TOF; DESIGN; ANTIBACTERIAL; CHLOROQUINE; CHEMISTRY; CATALYST; 8-HYDROXYQUINOLINE; DEHYDROGENATION in [Tabassum, Rukhsana; Ashfaq, Muhammad] Islamia Univ Bahawalpur, Dept Chem, Bahawalpur 36100, Pakistan; [Oku, Hiroyuki] Gunma Univ, Grad Sch Sci & Engn, Div Mol Sci, Gunma, Japan in 2021, Cited 93. Recommanded Product: 3-Nitrobenzaldehyde. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

A one-pot quick and efficient multicomponent reaction has been developed for the synthesis of a new series of functionalized 8-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives using 30 mol% ammonium acetate in ethanol as solvent. This economical protocol run smoothly to give variety of quinoline derivatives in 55% to 98% yield from inexpensive reagents and catalyst in mild reaction conditions. Various spectroscopic techniques like FTIR, H-1 NMR and C-13 NMR, MALDI-TOF-MS, and EI-MS were used to study and confirm their structure.

Recommanded Product: 3-Nitrobenzaldehyde. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Tabassum, R; Ashfaq, M; Oku, H or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

 

What advice would you give a new faculty member or graduate student interested in a career Benzophenone

Recommanded Product: 119-61-9. About Benzophenone, If you have any questions, you can contact Human, C; Danton, O; De Beer, D; Maruyama, T; Alexander, L; Malherbe, C; Hamburger, M; Joubert, E or concate me.

Recommanded Product: 119-61-9. Authors Human, C; Danton, O; De Beer, D; Maruyama, T; Alexander, L; Malherbe, C; Hamburger, M; Joubert, E in ELSEVIER SCI LTD published article about in [Human, Chantelle; Beer, Dalene De; Maruyama, Takuma; Alexander, Lara; Malherbe, Christiaan; Joubert, Elizabeth] Agr Res Council Infruitec Nietvoorbij, Plant Bioact Grp, Postharvest & Agroproc Technol, Private Bag X5026, ZA-7599 Stellenbosch, South Africa; [Danton, Ombeline; Hamburger, Matthias] Univ Basel, Pharmaceut Biol Pharmactr, Klingelbergstr 50, CH-4056 Basel, Switzerland; [Beer, Dalene De; Alexander, Lara; Joubert, Elizabeth] Stellenbosch Univ, Dept Food Sci, Private Bag X1, ZA-7600 Stellenbosch, South Africa; [Maruyama, Takuma] Tokyo Univ Agr & Technol, Dept Appl Biol Sci, Tokyo, Japan in 2021.0, Cited 39.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

Heat processing of ready-to-drink beverages is required to ensure a microbiologically safe product, however, this can result in the loss of bioactive compounds responsible for functionality. The objective of this study was to establish the thermal stability of a novel dihydrochalcone, 3′,5′-di-beta-D-glucopyranosyl-3-hydroxyphloretin (2), 3′,5′-di-beta-D-glucopyranosylphloretin (3) and other Cyclopia subternata phenolic compounds, in model solutions with or without citric acid and ascorbic acid. The solutions were heated at 93, 121 and 135 degrees C, relevant to pasteurisation, commercial sterilisation and ultra-high temperature (UHT) pasteurisation, respectively. For most compounds, the acids decreased the second order reaction rate constants, up to 27 times. Compound 2 (46.29 +/- 0.53 (g/100 g)(-1) h(-1)), and to a lesser extent compound 3 (5.94 +/- 0.01 (g/100 g)(-1) h(-1)) were the most thermounstable compounds when treated at 135 degrees C without added acids. Even though differential effects were observed for compounds at different temperatures and formulations, overall, the phenolic compounds were most stable under UHT pasteurisation conditions.

Recommanded Product: 119-61-9. About Benzophenone, If you have any questions, you can contact Human, C; Danton, O; De Beer, D; Maruyama, T; Alexander, L; Malherbe, C; Hamburger, M; Joubert, E or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

 

Our Top Choice Compound:2-Aminobenzamide

COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Zima, V; Albinana, CB; Rojikova, K; Pokorna, J; Pachl, P; Rezacova, P; Hudlicky, J; Navratil, V; Majer, P; Konvalinka, J; Kozisek, M; Machara, A or concate me.

COA of Formula: C7H8N2O. In 2019 BIOORGAN MED CHEM published article about STRUCTURAL-ANALYSIS; GLOBAL MORTALITY; 150 CAVITY; INHIBITORS; DESIGN; POTENT; OSELTAMIVIR; DISCOVERY; ZANAMIVIR; OUTBREAK in [Zima, Vaclav; Albinana, Carlos Berenguer; Hudlicky, Jason; Machara, Ales] Charles Univ Prague, Fac Sci, Dept Organ Chem, Hlavova 8, Prague 12800 2, Czech Republic; [Zima, Vaclav; Albinana, Carlos Berenguer; Rojikova, Katerina; Pokorna, Jana; Pachl, Petr; Rezacova, Pavlina; Hudlicky, Jason; Navratil, Vaclav; Majer, Pavel; Konvalinka, Jan; Kozisek, Milan; Machara, Ales] Gilead Sci, Czech Acad Sci, Inst Organ Chem & Biochem, Flemingovo 2, Prague 16610 6, Czech Republic; [Zima, Vaclav; Albinana, Carlos Berenguer; Rojikova, Katerina; Pokorna, Jana; Pachl, Petr; Rezacova, Pavlina; Hudlicky, Jason; Navratil, Vaclav; Majer, Pavel; Konvalinka, Jan; Kozisek, Milan; Machara, Ales] IOCB Res Ctr, Flemingovo 2, Prague 16610 6, Czech Republic; [Rojikova, Katerina] Charles Univ Prague, Fac Med 1, Katerinska 1660-32, Prague 12108, Czech Republic; [Rezacova, Pavlina] Acad Sci Czech Republ, Inst Mol Genet, Videnska 1083, Prague 14000 4, Czech Republic; [Konvalinka, Jan] Charles Univ Prague, Fac Sci, Dept Biochem, Hlavova 8, Prague 12800 2, Czech Republic in 2019, Cited 62. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

This study focuses on design, synthesis and in vitro evaluation of inhibitory potency of two series of sialylmimetic that target an exosite (150-cavity) adjacent to the active site of influenza neuraminidases from A/California/07/2009 (H1N1) pandemic strain and A/chicken/Nakorn-Patom/Thailand/CU-K2-2004 (H5N1). The structure-activity analysis as well as 3-D structure of the complex of parental compound with the pandemic neuraminidase p09N1 revealed high flexibility of the 150-cavity towards various modification of the neuraminidase inhibitors. Furthermore, our comparison of two methods for inhibition constant determination performed at slightly different pH values suggest that the experimental conditions of the measurement could dramatically influence the outcome of the analysis in the compound-dependent manner. Therefore, previously reported Ki values determined at non-physiological pH should be carefully scrutinized.

COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Zima, V; Albinana, CB; Rojikova, K; Pokorna, J; Pachl, P; Rezacova, P; Hudlicky, J; Navratil, V; Majer, P; Konvalinka, J; Kozisek, M; Machara, A or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

 

Something interesting about 90-44-8

HPLC of Formula: C14H10O. About Anthrone, If you have any questions, you can contact Zhang, KK; Fan, W; Huang, ZW; Chen, DF; Yao, ZW; Li, YF; Yang, YF; Qiu, DY or concate me.

HPLC of Formula: C14H10O. In 2019 IND CROP PROD published article about GENOME SEQUENCE; EXPRESSION; CASBENE; PROSTRATIN; PATHWAY; ANALOGS; CLONING; PLANTS in [Zhang, Kaikai; Yang, Yanfang; Qiu, Deyou] Chinese Acad Forestry, Res Inst Forestry, Key Lab Tree Breeding & Cultivat, State Key Lab Tree Genet & Breeding,State Forestr, Beijing 100091, Peoples R China; [Zhang, Kaikai; Chen, Duanfen; Yao, Zhiwang; Li, Yunfeng] Agr Univ Hebei, Coll Hort, Baoding 071001, Peoples R China; [Fan, Wei] Chinese Acad Forestry, State Key Lab Tree Genet & Breeding, Beijing 100091, Peoples R China; [Huang, Zhongwen] Henan Inst Sci & Technol, Henan Collaborat Innovat Ctr Modern Biol Breeding, Xinxiang 453003, Henan, Peoples R China in 2019, Cited 30. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8.

12-Deoxyphorbol-13-phenylacetate (DPP), found in Euphorbia resinifera, is a prototype of a new class of phorbol derivatives that function as protein kinase C activators with potent anti-tumor-promoting activity. To better understand the biosynthesis of DPP in E. resinifera and develop methods for its production, we used next-generation sequencing technologies to build a transcriptome dataset. We obtained a total of approximately 27,102,078 clean reads that were assembled into 90,448 unigenes. Of those, 129 and 59 unigenes were identified in the Terpenoid Backbone Biosynthesis (TBB) (KEGG map00900) and the Diterpenoid Biosynthesis (DB) (KEGG map00904) pathways, respectively. We investigated the expression patterns of 23 DPP biosynthesis-related genes and validated the results by quantitative real time PCR. The results showed that CMK (4-diphosphocytidyl-2-C-methyl-o-erythritol kinase), MECS (2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase), HDS (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase), and IPI (Isopentenyl-diphosphate Delta-isomerase) of the methylerythritol 4-phosphate (MEP) pathway had a higher expression compared to other genes of TBB, whereas the expression levels of genes involved in the mevalonic acid (MVA) pathway were relatively lower and not significantly different from each other. Furthermore, the expression of the 23 genes in root, stem and young stem differed, and the statistical results indicated that HMGS (Hydroxymethylglutaryl-CoA synthase), MVK (mevalonic acid), MECT (2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase), MECS, HDS and IPI in the TBB pathway as well as KS in the DB pathway were significantly and positively correlated with the CS (casbene synthase) gene. These results suggested that both cytosol-localized MVA and plastid-localized MEP pathways may have a significant contribution in DPP accumulation, with MEP pathway playing a dominant role. To the best of our knowledge, this study is the first transcriptome analysis of E. resinifera and the results reported here will aid the identification of functional genes and better understanding of DPP biosynthesis.

HPLC of Formula: C14H10O. About Anthrone, If you have any questions, you can contact Zhang, KK; Fan, W; Huang, ZW; Chen, DF; Yao, ZW; Li, YF; Yang, YF; Qiu, DY or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem