Name: Benzophenone. Lin, PP; Huang, LL; Feng, SX; Yang, S; Wang, HG; Huang, ZS; Li, QJ in [Lin, Peng-Peng; Huang, Long-Ling; Feng, Si-Xin; Yang, Shuang; Wang, Honggen; Huang, Zhi-Shu; Li, Qingjiang] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Prov Key Lab Chiral Mol & Drug Discover, Guangzhou 510006, Peoples R China; [Li, Qingjiang] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China published gem-Difluorination of Methylenecyclopropanes (MCPs) Featuring a Wagner-Meerwein Rearrangement: Synthesis of 2-Arylsubstituted gem-Difluorocyclobutanes in 2021.0, Cited 42.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9.
The geminal difluorocyclobutane core is a valuable structural element in medicinal chemistry. Strategies for gem-difluorocyclobutanes, especially the 2-substituted cases, are limiting and often suffer from harsh reaction conditions. Reported herein is a migratory gem-difluorination of aryl-substituted methylenecycloproanes (MCPs) for the synthesis of 2-arylsubstituted gem-difluorocyclobutanes. Commercially available Selectfluor (FTEDA-BF4) and Py center dot HF were used as the fluorine sources. The protocol proceeds via a Wagner-Meerwein rearrangement with mild reaction conditions, good functional group tolerance, and moderate to good yields. The product could be readily transformed to gem-difluorocyclobutane-containing carboxylic acid, amine, and alcohol, all of which are useful building blocks for biologically active molecule synthesis.
About Benzophenone, If you have any questions, you can contact Lin, PP; Huang, LL; Feng, SX; Yang, S; Wang, HG; Huang, ZS; Li, QJ or concate me.. Name: Benzophenone
Reference:
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