Quality Control of 2-Aminobenzamide. I found the field of Biochemistry & Molecular Biology very interesting. Saw the article Reactive OFF-ON type alkylating agents for higher-ordered structures of nucleic acids published in 2019, Reprint Addresses Nagatsugi, F (corresponding author), Tohoku Univ, Inst Multidisciplinary Res Adv Mat, Aoba Ku, 2-1-1 Katahira, Sendai, Miyagi 9808577, Japan.; Nagatsugi, F (corresponding author), Tohoku Univ, Grad Sch Sci, Dept Chem, Aoba Ku, Sendai, Miyagi 9808578, Japan.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide.
Higher-ordered structure motifs of nucleic acids, such as the G-quadruplex (G-4), mismatched and bulge structures, are significant research targets because these structures are involved in genetic control and diseases. Selective alkylation of these higher-order structures is challenging due to the chemical instability of the alkylating agent and side-reactions with the single- or double-strand DNA and RNA. We now report the reactive OFF-ON type alkylating agents, vinyl-quinazolinone (VQ) precursors with a sulfoxide, thiophenyl or thiomethyl group for the OFF-ON control of the vinyl reactivity. The stable VQ precursors conjugated with aminoacridine, which bind to the G-4 DNA, selectively reacted with a T base on the G-4 DNA in contrast to the single- and double-strand DNA. Additionally, the VQ precursor reacted with the T or U base in the AP-site, G-4 RNA and T-T mismatch structures. These VQ precursors would be a new candidate for the T or U specific alkylation in the higher-ordered structures of nucleic acids.
Quality Control of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Onizuka, K; Hazemi, ME; Sato, N; Tsuji, G; Ishikawa, S; Ozawa, M; Tanno, K; Yamada, K; Nagatsugi, F or concate me.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem