Product Details of 99-61-6. Authors Shaikh, S; Ramana, MMV in SPRINGER published article about in [Shaikh, Sarfaraz; Ramana, M. M. V.] Univ Mumbai, Dept Chem, Mumbai 400098, Maharashtra, India in 2021, Cited 40. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6
A series of 1-[aryl-(thiazol-2-ylamino)-methyl]-naphthalen-2-ol derivatives were synthesized using porcine pancreatic lipase as a catalyst. The major assets of this methodology were use of biocatalyst, non-toxic organic medium, mild reaction condition and good-to-excellent yield of desired products. The synthesized Betti bases were evaluated for in vitro anti-cholinesterase activity. Test compounds exhibited potential inhibitory activities towards AChE (IC50 = 0.82 to 4.27 mu M) as well as BuChE (IC50 = 2.18 to 9.64 mu M). Compound 4g exhibited highest inhibitory activity for both AChE (IC50 = 0.82 +/- 0.05 mu M) and BuChE (IC50 = 2.18 +/- 0.21 mu M) when compared to standard reference drug galantamine inferring that it acts a dual AChE/BuChE inhibitor. Kinetic studies of compound 4g suggested a mixed-type inhibition towards both AChE and BuChE with K-i values of 8.82 mu M and 12.41 mu M, respectively. Further, cell viability assay that compound 4(a-j) do not impart any toxicity to N2a cells. In addition, molecular docking studies were performed to corroborate the biological results. This is the first report on lipase-catalysed synthesis of Betti bases as well as for their potential in vitro anti-Alzheimer activity. [GRAPHICS] .
Product Details of 99-61-6. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Shaikh, S; Ramana, MMV or concate me.
Reference:
Thiomorpholine – Wikipedia,
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