Day: October 22, 2021

Authors Li, WL; Yin, Y; Shuai, W; Xu, FJ; Yao, H; Liu, J; Cheng, KG; Xu, JY; Zhu, ZY; Xu, ST in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about BINDING-SITE; TUBULIN INHIBITORS; MPC-6827; DESIGN; TARGET in [Li, Wenlong; Yin, Ying; Shuai, Wen; Xu, Feijie; Yao, Hong; Xu, Jinyi; Xu, Shengtao] China Pharmaceut Univ, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China; [Li, Wenlong; Yin, Ying; Shuai, Wen; Xu, Feijie; Yao, Hong; Xu, Jinyi; Xu, Shengtao] China Pharmaceut Univ, Dept Med Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China; [Liu, Jie] China Pharmaceut Univ, Dept Organ Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China; [Liu, Jie; Cheng, Keguang] Guangxi Normal Univ, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China; [Liu, Jie; Cheng, Keguang] Guangxi Normal Univ, Sch Chem & Pharm, Guilin 541004, Peoples R China; [Zhu, Zheying] Univ Nottingham, Sch Pharm, Div Mol Therapeut & Formulat, Univ Pk Campus, Nottingham NG7 2RD, England in 2019, Cited 26. Product Details of 88-68-6. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A series of novel quinazolines as tubulin inhibitors occupying three zones of colchicine domain have been designed and synthesized inspired by the recently disclosed crystal structure of verubulin analogue 6 with tubulin. Among the newly synthesized compounds, 19c showed noteworthy potency against K562, HepG2, KB, HCT-8 and MDB-MB-231 cancer cells. In vitro microtubule polymerization assays identified 19c as a potent tubulin assembly inhibitor, the binding mode of which with tubulin was confirmed by molecular modeling studies to occupy three zones of tubulin domain. Furthermore, 19c disrupted the intracellular microtubule network, caused G2/M phase arrest, induced cell apoptosis and depolarized mitochondria of K562 cells. 19c also reduced the cell migration and disrupted the capillary-like tube formation of human umbilical vein endothelial cells (HUVECs). Importantly, 19c significantly and dose dependently inhibited tumor growth in H22 liver cancer xenograft mouse model. All these results suggested that 19c deserves further research as a novel and potential anti-tubulin agent for the treatment of cancers.

About 2-Aminobenzamide, If you have any questions, you can contact Li, WL; Yin, Y; Shuai, W; Xu, FJ; Yao, H; Liu, J; Cheng, KG; Xu, JY; Zhu, ZY; Xu, ST or concate me.. HPLC of Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Category: thiomorpholine. I found the field of Chemistry very interesting. Saw the article Effect of Fe(iii)-based MOFs on the catalytic efficiency of the tandem cyclooxidative reaction between 2-aminobenzamide and alcohols published in 2020, Reprint Addresses Doan, TLH (corresponding author), Ctr Innovat Mat & Architectures INOMAR, Ho Chi Minh City, Vietnam.; Doan, TLH (corresponding author), Vietnam Natl Univ Ho Chi Minh City, Ho Chi Minh City, Vietnam.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide.

The catalytic properties of metal-organic frameworks (MOFs) containing triangular Fe(iii) clusters in the promotion of organic syntheses and photocatalysis applications have been receiving substantial attention for decades. These clusters are appealing due to the strong Lewis acidity afforded by coordinatively unsaturated sites upon the removal of solvent from the framework. In this paper, triangular Fe(iii) cluster-based MOFs were shown to be highly efficient heterogeneous catalysts for the solvent-free one-pot condensation of 2-aminobenzamide and alcohols to form quinazolin-4-ones under microwave irradiation. The Fe-MOF catalysts ranging from microporous to mesoporous structures with a variety of geometrical pore structures were investigated. Because of the open accessible spaces for reactants and high density of active sites, MOF-907, built from trimer Fe clusters and a mixture of two linkers, was more effective than other Fe(iii)-MOFs. The catalyst can be used for a broad substrate scope and recycled several times without a significant drop-off in its activity.

Category: thiomorpholine. About 2-Aminobenzamide, If you have any questions, you can contact Dang, MHD; Nguyen, TTM; Nguyen, LHT; Nguyen, TTT; Phan, TB; Tran, PH; Doan, TLH or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

SDS of cas: 88-68-6. In 2019 ADV SYNTH CATAL published article about ONE-POT SYNTHESIS; CRYSTAL-STRUCTURES; BORYLATION; FUNCTIONALIZATION; DERIVATIVES in [Wang, Hao-Jie; Zhang, Mo; Li, Wen-Jing; Ni, Yu; Lin, Jin; Zhang, Zhan-Hui] Hebei Normal Univ, Coll Chem & Mat Sci, Natl Demonstrat Ctr Expt Chem Educ, Hebei Key Lab Organ Funct Mol, Shijiazhuang 050024, Hebei, Peoples R China in 2019, Cited 50. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

An efficient Ni/Pd catalyzed chemoselective synthesis of 1,3,2-benzodiazaborininones from boronic acids and anthranilamide has been developed. This protocol allows for the rapid and straightforward access to a wide range of 1,3,2-benzodiazaborininones at roomtemperature with excellent functional group tolerance.

SDS of cas: 88-68-6. About 2-Aminobenzamide, If you have any questions, you can contact Wang, HJ; Zhang, M; Li, WJ; Ni, Y; Lin, J; Zhang, ZH or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article 3D-QSAR assisted identification of FABP4 inhibitors: An effective scaffold hopping analysis/QSAR evaluation WOS:000458112400028 published article about ACID-BINDING PROTEIN; LINEAR-REGRESSION; CELL-GROWTH; QSAR; EXPRESSION; PLS; DISCOVERY; PROSTATE; DESIGN; POTENT in [Floresta, Giuseppe; Spampinato, Ambra; Zagni, Chiara; Rescifina, Antonio] Univ Catania, Dept Drug Sci, Vle A Doria 6, I-95125 Catania, Italy; [Floresta, Giuseppe] Univ Catania, Dept Chem Sci, Vle A Doria, I-95125 Catania, Italy; [Floresta, Giuseppe; Cilibrizzi, Agostino] Kings Coll London, Inst Pharmaceut Sci, Stamford St, London SE1 9NH, England; [Cilibrizzi, Agostino; Abbate, Vincenzo] Kings Coll London, Sch Populat Hlth & Environm Sci, Kings Forens, Franklin Wilkins Bldg,150 Stamford St, London SE1 9NH, England in 2019, Cited 68. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Safety of 2-Aminobenzamide

Following on the recent publication of pharmacologically relevant effects, small molecule inhibitors of adipocyte fatty-acid binding protein 4 (FABP4) have attracted high interest. FABP4 is mainly expressed in macrophages and adipose tissue, where it regulates fatty acid storage and lipolysis, being also an important mediator of inflammation. In this regard, FABP4 recently demonstrated an interesting molecular target for the treatment of type 2 diabetes, other metabolic diseases and some type of cancers. In the past years, hundreds of effective FABP4 inhibitors have been synthesized. In this paper, a quantitative structure-activity relationship (QSAR) model has been produced, in order to predict the bioactivity of FABP4 inhibitors. The methodology has been combined with a scaffold-hopping approach, allowing to identify three new molecules that act as effective inhibitors of this protein. These molecules, synthesized and tested for their FABP4 inhibitor activity, showed IC(50 )values between 3.70 and 5.59 mu M, with a high level of agreement with the predicted values.

Safety of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Floresta, G; Cilibrizzi, A; Abbate, V; Spampinato, A; Zagni, C; Rescifina, A or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: Anthrone. Recently I am researching about GRAPHENE OXIDE; POLYMERIZATION, Saw an article supported by the Japan Society for the Promotion of Science (JSPS)Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of Science [JP17K14469]; JSPS KAKENHIMinistry of Education, Culture, Sports, Science and Technology, Japan (MEXT)Japan Society for the Promotion of ScienceGrants-in-Aid for Scientific Research (KAKENHI) [JP16H06280]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Nishikawa, T; Narita, H; Ogi, S; Sato, Y; Yamaguchi, S. The CAS is 90-44-8. Through research, I have a further understanding and discovery of Anthrone

The hydrophobicity and CH/pi-interaction-driven self-assembly of an amphiphile that contains a biphenylanthracene group furnishes two-dimensional aggregates in dilute aqueous solution. A windmill-shaped molecular packing structure that arises from multiple intermolecular CH/pi interactions of the aromatic hydrocarbons is the key motif for the self-assembly into micrometer-scale nanosheets.

Recommanded Product: Anthrone. About Anthrone, If you have any questions, you can contact Nishikawa, T; Narita, H; Ogi, S; Sato, Y; Yamaguchi, S or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Mohamed, MG; Ahmed, MMM; Du, WT; Kuo, SW in MDPI published article about in [Mohamed, Mohamed Gamal; Ahmed, Mahmoud M. M.; Du, Wei-Ting; Kuo, Shiao-Wei] Natl Sun Yat Sen Univ, Dept Mat & Optoelect Sci, Ctr Crystal Res, Kaohsiung 804, Taiwan; [Mohamed, Mohamed Gamal] Assiut Univ, Chem Dept, Fac Sci, Assiut 71516, Egypt; [Ahmed, Mahmoud M. M.] Chung Yuan Christian Univ, Chem Dept, Taoyuan 320, Taiwan; [Kuo, Shiao-Wei] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 807, Taiwan in 2021.0, Cited 85.0. Recommanded Product: 119-61-9. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

In this study, we successfully synthesized two types of meso/microporous carbon materials through the carbonization and potassium hydroxide (KOH) activation for two different kinds of hyper-crosslinked polymers of TPE-CPOP1 and TPE-CPOP2, which were synthesized by using Friedel-Crafts reaction of tetraphenylethene (TPE) monomer with or without cyanuric chloride in the presence of AlCl3 as a catalyst. The resultant porous carbon materials exhibited the high specific area (up to 1100 m(2) g(-1)), total pore volume, good thermal stability, and amorphous character based on thermogravimetric (TGA), N-2 adsoprtion/desorption, and powder X-ray diffraction (PXRD) analyses. The as-prepared TPE-CPOP1 after thermal treatment at 800 degrees C (TPE-CPOP1-800) displayed excellent CO2 uptake performance (1.74 mmol g(-1) at 298 K and 3.19 mmol g(-1) at 273 K). Furthermore, this material possesses a high specific capacitance of 453 F g(-1) at 5 mV s(-1) comparable to others porous carbon materials with excellent columbic efficiencies for 10,000 cycle at 20 A g(-1).

Recommanded Product: 119-61-9. About Benzophenone, If you have any questions, you can contact Mohamed, MG; Ahmed, MMM; Du, WT; Kuo, SW or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Synthesis of quinazolin-4(3H)-ones via electrochemical decarboxylative cyclization of alpha-keto acids with 2-aminobenzamides WOS:000609172600003 published article about O-AMINOBENZAMIDES; CINNAMIC-ACIDS; C-C; QUINAZOLINONES; HETEROCYCLES; ACTIVATION; ALCOHOLS; CATALYST in [Tian, Qing; Zhang, Jinli; Xu, Liang; Wei, Yu] Shihezi Univ, Key Lab Green Proc Chem Engn Xinjiang Bingtuan, Sch Chem & Chem Engn, Shihezi 832003, Peoples R China in 2021, Cited 50. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Quality Control of 2-Aminobenzamide

Herein, an environmentally benign electrochemical protocol has been disclosed for the synthesis of quinazolin-4 (3H)-one derivatives from readily available alpha-keto acids and 2-aminobenzamides. This decarboxylative cyclization process proceeds conveniently in the absence of any homogeneous metal catalysts, bases, or external oxidants. This protocol also features CO2 by-products, mild reaction conditions (room temperature and air atmosphere), and a wide variety of substrate scope, including an array of 2,3-disubstituted quinazolinone products.

Quality Control of 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Tian, Q; Zhang, JL; Xu, L; Wei, Y or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about IMMUNODEFICIENCY-VIRUS TYPE-1; NUCLEOCAPSID PROTEIN; INFECTION; THIOESTERS; ACTIVATION; INHIBITORS; CHARMM; NCP7, Saw an article supported by the Intramural Research Program of NIDDK, NIH; Office of AIDS Research at NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Cancer Institute (NCI) [ZICBC011380] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [ZIADK075135] Funding Source: NIH RePORTER. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Nikolayevskiy, H; Robello, M; Scerba, MT; Pasternak, EH; Saha, M; Hartman, TL; Buchholz, CA; Buckheit, RW; Durell, SR; Appella, DH. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. Name: 2-Aminobenzamide

Mercaptobenzamide thioesters and thioethers are chemically simple HIV-1 maturation inhibitors with a unique mechanism of action, low toxicity, and a high barrier to viral resistance. A structure-activity relationship (SAR) profile based on 39 mercaptobenzamide prodrug analogs exposed divergent activity/toxicity roles for the internal and terminal amides. To probe the relationship between antiviral activity and toxicity, we generated an improved computational model for the binding of mercaptobenzamide thioesters (SAMTs) to the HIV-1 NCp7 C-terminal zinc finger, revealing the presence of a second low-energy binding orientation, hitherto undisclosed. Finally, using NMR-derived thiol -thioester exchange equilibrium constants, we propose that thermodynamics plays a role in determining the antiviral activity observed in the SAR profile. (C) 2019 Published by Elsevier Masson SAS.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Formula: C13H10O. Authors Xi, ZW; Yang, L; Wang, DY; Feng, CW; Qin, YF; Shen, YM; Pu, CD; Peng, XG in AMER CHEMICAL SOC published article about in [Xi, Zi-Wei; Wang, Dan-Yan; Feng, Chuan-Wei; Shen, Yong-Miao] Zhejiang Sci Tech Univ, Dept Chem, Key Lab Surface & Interface Sci Polymer Mat Zheji, Hangzhou 310018, Zhejiang, Peoples R China; [Yang, Lei; Peng, Xiaogang] Zhejiang Univ, Ctr Chem Novel & High Performance Mat, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China; [Qin, Yufeng; Pu, Chaodan] Shanghai Tech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China in 2021.0, Cited 133.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

We present an efficient and versatile visible light-driven methodology to transform aryl aldehydes and ketones chemoselectively either to alcohols or to pinacol products with CdSe/CdS core/shell quantum dots as photocatalysts. Thiophenols were used as proton and hydrogen atom donors and as hole traps for the excited quantum dots (QDs) in these reactions. The two products can be switched from one to the other simply by changing the amount of thiophenol in the reaction system. The core/shell QD catalysts are highly efficient with a turn over number (TON) larger than 4 X 10(4) and 4 X 10(5) for the reduction to alcohol and pinacol formation, respectively, and are very stable so that they can be recycled for at least 10 times in the reactions without significant loss of catalytic activity. The additional advantages of this method include good functional group tolerance, mild reaction conditions, the allowance of selectively reducing aldehydes in the presence of ketones, and easiness for large scale reactions. Reaction mechanisms were studied by quenching experiments and a radical capture experiment, and the reasons for the switchover of the reaction pathways upon the change of reaction conditions are provided.

Formula: C13H10O. About Benzophenone, If you have any questions, you can contact Xi, ZW; Yang, L; Wang, DY; Feng, CW; Qin, YF; Shen, YM; Pu, CD; Peng, XG or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2020 CHEM PHARM BULL published article about CELL LUNG-CANCER; ACTIVATED PROTEIN-KINASE; EGFR INHIBITORS; RESISTANT; MUTATIONS; AZD9291; POTENT; DISCOVERY; AFATINIB; TKI in [Zhang, Mingguang; Wang, Yunyun; Li, Mingxin; Wang, Shifa] Nanjing Forestry Univ, Coll Chem Engn, Nanjing 210037, Peoples R China; [Zhang, Mingguang; Wang, Jia; Liu, Zhaogang; Shi, Jingmiao; Zhu, Yongqiang] Jiangsu Chia Tai Fenghai Pharmaceut Co Ltd, 9 Weidi Rd, Nanjing 210046, Peoples R China; [Zhu, Yongqiang] Nanjing Normal Univ, Coll Life Sci, Nanjing 210046, Peoples R China in 2020, Cited 31. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Name: 2-Aminobenzamide

Inhibition of the epidermal growth factor receptor (EGFR) has been proved to be one of the most promising strategies for the treatment of non-small cell lung cancers. A series of 2-aryl-4-amino substituted quinazoline derivatives were designed and synthesized with the purpose to overcome L858R/T790M/C797S (CTL) triple mutant drug resistance and the biological activity for inhibition of CTL kinases and EGFR wild type (WT) were evaluated. Three compounds (20, 24 and 27) showed excellent inhibitory activities against EGFR kinases triple mutant CTL (IC50 < 1 mu M) and high selectivity (IC50: WT/CTL >10000). Cell line evaluation showed that the most potent compound 27 was significantly potent against H1975-EGFR L858R/T790M (IC50 = 3.3 mu M) and H1975-EGFR L858R/T790M/C797S (IC50 = 1.2 mu M). Compound 27 also exhibited good microsomes stabilities in human, rat and mouse liver species, but low bioavailability. This work would be very useful for discovering new quinazoline derivatives as tyrosine kinase inhibitors targeting triple mutant L858R/T790M/C797S.

Name: 2-Aminobenzamide. About 2-Aminobenzamide, If you have any questions, you can contact Zhang, MG; Wang, YY; Wang, J; Liu, ZG; Shi, JM; Li, MX; Zhu, YQ; Wang, SF or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem