Recently I am researching about IMMUNODEFICIENCY-VIRUS TYPE-1; NUCLEOCAPSID PROTEIN; INFECTION; THIOESTERS; ACTIVATION; INHIBITORS; CHARMM; NCP7, Saw an article supported by the Intramural Research Program of NIDDK, NIH; Office of AIDS Research at NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA; NATIONAL CANCER INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Cancer Institute (NCI) [ZICBC011380] Funding Source: NIH RePORTER; NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) [ZIADK075135] Funding Source: NIH RePORTER. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Nikolayevskiy, H; Robello, M; Scerba, MT; Pasternak, EH; Saha, M; Hartman, TL; Buchholz, CA; Buckheit, RW; Durell, SR; Appella, DH. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. Name: 2-Aminobenzamide
Mercaptobenzamide thioesters and thioethers are chemically simple HIV-1 maturation inhibitors with a unique mechanism of action, low toxicity, and a high barrier to viral resistance. A structure-activity relationship (SAR) profile based on 39 mercaptobenzamide prodrug analogs exposed divergent activity/toxicity roles for the internal and terminal amides. To probe the relationship between antiviral activity and toxicity, we generated an improved computational model for the binding of mercaptobenzamide thioesters (SAMTs) to the HIV-1 NCp7 C-terminal zinc finger, revealing the presence of a second low-energy binding orientation, hitherto undisclosed. Finally, using NMR-derived thiol -thioester exchange equilibrium constants, we propose that thermodynamics plays a role in determining the antiviral activity observed in the SAR profile. (C) 2019 Published by Elsevier Masson SAS.
About 2-Aminobenzamide, If you have any questions, you can contact Nikolayevskiy, H; Robello, M; Scerba, MT; Pasternak, EH; Saha, M; Hartman, TL; Buchholz, CA; Buckheit, RW; Durell, SR; Appella, DH or concate me.. Recommanded Product: 2-Aminobenzamide
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem