Day: October 26, 2021

I found the field of Plant Sciences; Chemistry; Pharmacology & Pharmacy very interesting. Saw the article Bioactive naphthoquinone and anthrone derivatives from endophytic Micromonospora sp. NEAU-gq13 published in 2019. Category: thiomorpholine, Reprint Addresses Wang, JD (corresponding author), Zhejiang Hisun Pharmaceut Co Ltd, Zhejiang Key Lab Antifungal Drugs, Taizhou 318000, Peoples R China.; Xiang, WS (corresponding author), Northeast Agr Univ, Sch Life Sci, Life Sci & Biotechnol Res Ctr, Harbin 150030, Heilongjiang, Peoples R China.. The CAS is 90-44-8. Through research, I have a further understanding and discovery of Anthrone

Two new naphthalenone derivatives, 5-hydroxy-4-oxo-2-(2-oxopropyl)-1,2,3,4-tetrahydronaphthalen-1-yl acetate (1) and 5-hydroxy-2-(2-hydroxypropyl)naphthalene-1,4-dione (2), together with two new anthrone derivatives, (S)-2,5-dihydroxy-2-methyl-1,2,3,4-tetrahydroanthracene-9,10-dione (3) and 4,5-dihydroxy-2-methyl-9H-xanthen-9-one (4), were isolated from the fermentation broth of endophytic Micromonospora sp. NEAU-gq13. Their structures were determined by 1D-NMR, 2D-NMR, and HR-ESI-MS analysis. Compounds 2 and 3 exhibited strong cytotoxic activity against human central nervous system cancer (SF-268) with the IC50 values of 3.04 and 5.66 mu g/ml, respectively. Moreover, compound 2 also displayed potent activity against human liver cancer (HepG2) with an IC50 value of 1.01 mu g/ml.

About Anthrone, If you have any questions, you can contact Li, JS; Zhang, H; Qi, H; Wang, JD; Xiang, WS or concate me.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Ram, S; Shaifali; Chauhan, AS; Sheetal; Sharma, AK; Das, P in WILEY-V C H VERLAG GMBH published article about CATALYZED OXIDATIVE SYNTHESIS; CASCADE SYNTHESIS; O-AMINOBENZAMIDES; N-HETEROCYCLES; LUOTONIN-A; QUINAZOLIN-4(3H)-ONES; DERIVATIVES; CYCLIZATION in [Ram, Shankar; Shaifali; Chauhan, Arvind Singh; Sheetal; Sharma, Ajay Kumar; Das, Pralay] CSIR Inst Himalayan Bioresource Technol, Nat Prod Chem & Proc Dev Div, Palampur 176061, Himachal Prades, India; [Ram, Shankar; Shaifali; Chauhan, Arvind Singh; Sheetal; Sharma, Ajay Kumar; Das, Pralay] CSIR IHBT, Acad Sci & Innovat Res, Palampur 176061, Himachal Prades, India in 2019, Cited 53. Recommanded Product: 88-68-6. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

An efficient and convenient strategy for the synthesis of diversely substituted quinazolinones from o-carbamoyl/cyano aniline and aryl iodides using oxalic acid as a CO source under polystyrene supported palladium (Pd@PS) nanoparticles (NPs) catalyzed conditions has been developed. In this study, oxalic acid has been employed as safe, economic, environmentally benign, sustainable and bench-stable, solid CO surrogate under Double-Layer-Vial (DLV) system for the synthesis of 2-aryl quinazolinones. This methodology does not require any special high-pressure equipment like autoclaves, microwaves, etc. Moreover, a simple procedure for catalyst preparation, catalyst recyclability, easy handling of reaction, additive and base-free generation of CO, excellent to good yields and vast substrate scope are the additional features of developed protocol.

Recommanded Product: 88-68-6. About 2-Aminobenzamide, If you have any questions, you can contact Ram, S; Shaifali; Chauhan, AS; Sheetal; Sharma, AK; Das, P or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: C7H5NO3. Authors Khoshdel, MA; Shirini, F; Langarudi, MSN; Zabihzadeh, M; Biglari, M in ROYAL SOC CHEMISTRY published article about in [Alipour Khoshdel, Meysam; Shirini, Farhad; Nikoo Langarudi, Mohaddeseh Safarpoor; Zabihzadeh, Mehdi; Biglari, Mohammad] Univ Guilan, Dept Chem, Coll Sci, Rasht 4133519141, Iran in 2021.0, Cited 44.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

The development of environmentally benign synthetic protocols has attracted increasing attention in recent organic syntheses. As a part of this concept, our group synthesized a new natural deep eutectic solvent (NADES) by using gabapentin and choline chloride. After characterization by FTIR, H-1 and C-13 NMR, and mass spectra, the prepared NADES was utilized as an efficacious catalyst for the synthesis of 4H-pyran scaffolds such as tetrahydrobenzo[b]pyran and pyrano[2,3-d]pyrimidinone(thione) derivatives. The use of inexpensive and bio-compatible reagents for the synthesis of the catalyst, a simple and green procedure for the preparation of the catalyst and products, short reaction times, high yields of the products, and applicability to large-scale synthesis are the prominent features of this protocol. Also, the catalyst could be recovered easily and recycled up to five times without significant loss of its catalytic activity.

About 3-Nitrobenzaldehyde, If you have any questions, you can contact Khoshdel, MA; Shirini, F; Langarudi, MSN; Zabihzadeh, M; Biglari, M or concate me.. COA of Formula: C7H5NO3

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Aerobic oxidative synthesis of quinazolinones and benzothiazoles in the presence of laccase/DDQ as a bioinspired cooperative catalytic system under mild conditions WOS:000528043700039 published article about ONE-POT SYNTHESIS; HETEROGENEOUS CATALYST; SELECTIVE OXIDATION; C-H; EFFICIENT; DDQ; DERIVATIVES; ALCOHOLS; GREEN; 2-ARYLBENZOTHIAZOLES in [Ghorashi, Nadia; Shokri, Zahra; Moradi, Reza; Rostami, Amin] Univ Kurdistan, Fac Sci, Dept Chem, Sanandaj 6617715175, Iran; [Abdelrasoul, Amira; Rostami, Amin] Univ Saskatchewan, Dept Chem & Biol Engn, 57 Campus Dr, Saskatoon, SK S7N 5A9, Canada in 2020, Cited 53. Recommanded Product: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The current study applied laccase/DDQ as a bioinspired cooperative catalytic system for the synthesis of quinazolinones (80-95% yield) and benzothiazoles (65-98% yield) using air or O-2 as ideal oxidants in aqueous media at ambient temperature. The aerobic oxidative cyclization reactions occur in two steps: (i) chemical cyclization; (ii) chemoenzymatic oxidation. These methods are more environment-friendly, efficient, simple and practical than other reported methods due to the use of O-2 as an oxidant, laccase as an eco-friendly biocatalyst, aqueous media as the solvent and free from any toxic transition metal and halide catalysts. Therefore, these methods can be applied in pharmaceutical and other sensitive synthetic procedures.

About 2-Aminobenzamide, If you have any questions, you can contact Ghorashi, N; Shokri, Z; Moradi, R; Abdelrasoul, A; Rostami, A or concate me.. Recommanded Product: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Product Details of 88-68-6. Authors Nguyen, TTT; Nguyen, L; Ngo, QA; Koleski, M; Nguyen, TB in ROYAL SOC CHEMISTRY published article about in [Nguyen, Thi Thu Tram] Can Tho Univ Med & Pharm, Dept Chem, Fac Sci, Can Tho, Vietnam; [Nguyen, Le Anh; Ngo, Quoc Anh] Vietnam Acad Sci & Technol, Inst Chem, 18 Hoang Quoc Viet, Hanoi, Vietnam; [Nguyen, Le Anh; Ngo, Quoc Anh] Grad Univ Sci & Technol, Vietnam Acad Sci & Technol, 18 Hoang Quoc Viet, Hanoi, Vietnam; [Koleski, Marina; Nguyen, Thanh Binh] Univ Paris Saclay, Univ Paris Sud, CNRS UPR 2301, Inst Chim Subst Nat, 1 Av Terrasse, F-91198 Gif Sur Yvette, France in 2021, Cited 57. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Thioamides could be conveniently synthesized in good to excellent yields via DMSO-promoted oxidative coupling of methylhetarenes with amines in the presence of a near stoichiometric amount of sulfur (1.25 equiv.). Both aliphatic and aromatic amines were found to be competent substrates. When anilines o-substituted by cyclizable groups such as OH, NH2, NHPh, SH and CONH2 were used as amine substrates, the corresponding hybrid bis-aza-heterocycles were formed in high yields even with a sulfur loading as low as 0.5 equiv.

About 2-Aminobenzamide, If you have any questions, you can contact Nguyen, TTT; Nguyen, L; Ngo, QA; Koleski, M; Nguyen, TB or concate me.. Product Details of 88-68-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 90-44-8. Byrne, AJ; Bright, SA; McKeown, JP; O’Brien, JE; Twamley, B; Fayne, D; Williams, DC; Meegan, MJ in [Byrne, Andrew J.; McKeown, James P.; Meegan, Mary J.] Trinity Coll Dublin, Sch Pharm & Pharmaceut Sci, Trinity Biomed Sci Inst, 152-160 Pearse St, Dublin D02 R590 2, Ireland; [Bright, Sandra A.; Fayne, Darren; Williams, D. Clive] Trinity Coll Dublin, Sch Biochem & Immunol, Trinity Biomed Sci Inst, 152-160 Pearse St, Dublin D02 R590 2, Ireland; [O’Brien, John E.; Twamley, Brendan] Trinity Coll Dublin, Sch Chem, Trinity Biomed Sci Inst, 152-160 Pearse St, Dublin D02 R590 2, Ireland published Design, Synthesis and Biochemical Evaluation of Novel Ethanoanthracenes and Related Compounds to Target Burkitt’s Lymphoma in 2020, Cited 73. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8.

Lymphomas (cancers of the lymphatic system) account for 12% of malignant diseases worldwide. Burkitt’s lymphoma (BL) is a rare form of non-Hodgkin’s lymphoma in which the cancer starts in the immune B-cells. We report the synthesis and preliminary studies on the antiproliferative activity of a library of 9,10-dihydro-9,10-ethanoanthracene based compounds structurally related to the antidepressant drug maprotiline against BL cell lines MUTU-1 and DG-75. Structural modifications were achieved by Diels-Alder reaction of the core 9-(2-nitrovinyl)anthracene with number of dienophiles including maleic anhydride, maleimides, acrylonitrile and benzyne. The antiproliferative activity of these compounds was evaluated in BL cell lines EBV- MUTU-1 and EBV+ DG-75 (chemoresistant). The most potent compounds 13j, 15, 16a, 16b, 16c, 16d and 19a displayed IC50 values in the range 0.17-0.38 mu M against the BL cell line EBV- MUTU-1 and IC50 values in the range 0.45-0.78 mu M against the chemoresistant BL cell line EBV+ DG-75. Compounds 15, 16b and 16c demonstrated potent ROS dependent apoptotic effects on the BL cell lines which were superior to the control drug taxol and showed minimal cytotoxicity to peripheral blood mononuclear cells (PBMCs). The results suggest that this class of compounds merits further investigation as antiproliferative agents for BL.

Recommanded Product: 90-44-8. About Anthrone, If you have any questions, you can contact Byrne, AJ; Bright, SA; McKeown, JP; O’Brien, JE; Twamley, B; Fayne, D; Williams, DC; Meegan, MJ or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Residual Larvicidal Activity of Quinones againstAedes aegypti WOS:000569742000001 published article about PLANT-EXTRACTS; L.; CERRADO in [Silva, Raquel L.; Demarque, Daniel P.; Dusi, Renata G.; Sousa, Joao Paulo B.; Albernaz, Lorena C.; Espindola, Laila S.] Univ Brasilia, Lab Farmacognosia, Campus Univ Darcy Ribeiro, BR-70910900 Brasilia, DF, Brazil in 2020, Cited 36. Quality Control of Anthrone. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8

The number of documented dengue cases has increased dramatically in recent years due to transmission through theAedes aegyptimosquito bite. Vector control remains the most effective measure to protect against this and other arboviral diseases including Zika, chikungunya and (urban) yellow fever, with an established vaccine only available for yellow fever. Although the quinone class shows potential as leading compounds for larvicide development, limited information restricts the development of optimized structures and/or formulations. Thus, in this contribution we investigated the larvicidal and pupicidal activity of three quinone compounds isolated from aConnarus suberosusroot wood ethyl acetate extract together with 28 quinones from other sources. Eight quinones demonstrated larvicidal activity, of which tectoquinone (4) proved to be the most active (LC(50)1.1 mu g/mL). The essential residual effect parameter of four of these quinones was evaluated in laboratory trials, with tectoquinone (4) and 2-ethylanthraquinone (7) presenting the most prolonged activity. In small-scale field residual tests, tectoquinone (4) caused 100% larvae mortality over 5 days, supporting its selection for formulation trials to develop a prototype larvicide to controlAe. aegypti.

Quality Control of Anthrone. About Anthrone, If you have any questions, you can contact Silva, RL; Demarque, DP; Dusi, RG; Sousa, JPB; Albernaz, LC; Espindola, LS or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Safety of Benzophenone. Authors Von Nehring, ES; Dragojlovic, V in AMER CHEMICAL SOC published article about in [Von Nehring, Erich Scott; Dragojlovic, Veljko] Florida Atlantic Univ, Wilkes Honors Coll, Jupiter, FL 33458 USA in 2021.0, Cited 4.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

A relatively large number of organic and inorganic chemistry reagents are air- or moisture-sensitive, and undergraduate students should be trained in their use. When handling such reagents, it is important to select the correct syringe and to use that syringe correctly. We have found that the best syringe for use in an undergraduate setting is a fully plastic polypropylene (PP) Luer lock syringe. While generally safe, such a syringe should be treated as a single-use syringe. Repeated exposure to an organic solvent causes progressively more resistance to the movement of the plunger, or its complete freeze. Thus, when drawing in a volume of liquid that is close to the capacity of the syringe, the plunger could be inadvertently pulled out causing a spill.

Safety of Benzophenone. About Benzophenone, If you have any questions, you can contact Von Nehring, ES; Dragojlovic, V or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

HPLC of Formula: C10H12O3. Recently I am researching about ISOCYANIDE INSERTION REACTION; BAYLIS-HILLMAN ADDUCTS; CARBOXYLIC-ACIDS; STEREOSELECTIVE-SYNTHESIS; ONE-POT; COUPLING REACTION; ESTERIFICATION; EFFICIENT; ACCESS; ALDEHYDES, Saw an article supported by the National Key Research and Development Program of China [2017YFB0102900]; State Key Laboratory of Applied Organic Chemistry, Lanzhou UniversityLanzhou University; Natural Science Foundation of ShanghaiNatural Science Foundation of Shanghai [18ZR1413900]; Shanghai Pujiang ProgramShanghai Pujiang Program [17PJD016]. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Chen, YY; Li, CL; Cui, YM; Sun, MM; Jia, XS; Li, J. The CAS is 104-21-2. Through research, I have a further understanding and discovery of 4-Methoxybenzyl acetate

A novel oxidative esterification of 1-arylprop-2-en-1-ols with toluene derivatives catalyzed by tetrabutylammonium iodide (TBAI) is reported. The optimization of the reaction conditions illustrates that each of experiment parameters including the catalyst, solvent, and oxidant is significant for present oxidative functionalization. This metal-free protocol has a broad substrate scope including the halogen groups for further functionalization and enriches the reactivity profile of allyl alcohol and toluene derivatives. In addition, this protocol represents a new transformation of allyl alcohol involving C-C bond cleavage and C-O bond forming.

HPLC of Formula: C10H12O3. About 4-Methoxybenzyl acetate, If you have any questions, you can contact Chen, YY; Li, CL; Cui, YM; Sun, MM; Jia, XS; Li, J or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2021.0 ORGANOMETALLICS published article about N-HETEROCYCLIC CARBENE; DIPALLADIUM COMPLEXES; HECK REACTION; REDUCTION; NITROARENES in [Lin, Shih-Chieh Aaron; Su, Bo-Kai; Liu, Yi-Hung; Peng, Shie-Ming; Liu, Shiuh-Tzung] Natl Taiwan Univ, Dept Chem, Taipei 10617, Taiwan in 2021.0, Cited 38.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9. COA of Formula: C13H10O

Complexation of L [L = 5-phenyl-2,8-di-2-pyridinyl-anthyridine] with [Pd(CH3CN)(4)](BF4)(2) and [Pd(CH3CN)(3)Cl](BF4) in a molar ratio of 1:2 rendered the corresponding dinuclear complexes [Pd2L (CH3CN)(4)](BF4)(4) (1) and [Pd2L (CH3CN)(2)Cl-2](BF4)(2) (2), respectively. However, treatment of L with (COD)PdCl2 followed by anion exchange yielded a tetranuclear complex [Pd4L3Cl4](PF6)(4)(4a). Structures of these complexes are characterized by both spectroscopy and X-ray crystallography. Interconversion of these three complexes was studied via the manipulation of stoichiometric ratio of ligand to metal precursor. The catalytic activity of these complexes for carbonylative Suzuki-Miyaura cross-coupling was investigated. Complex 2 shows an excellent catalytic activity on the reaction of aryl iodide with arylboronic acid in the presence of atmospheric pressure of CO to give the corresponding benzophenones.

About Benzophenone, If you have any questions, you can contact Lin, SCA; Su, BK; Liu, YH; Peng, SM; Liu, ST or concate me.. COA of Formula: C13H10O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem