Day: October 27, 2021

Formula: C7H8N2O. In 2021 ACTA PHARMACOL SIN B published article about MULTICENTER PHASE-II; BREQUINAR SODIUM; IMMUNOSUPPRESSIVE DRUG; PLASMODIUM-FALCIPARUM; PYRIMIDINE SYNTHESIS; DHODH; VIDOFLUDIMUS; LEFLUNOMIDE; DISCOVERY; BLOCKADE in [Zeng, Fanxun; Yang, Guantian; Zhang, Letian; Xu, Xiaoyong] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China; [Li, Shiliang; Luo, Yating; Qi, Tiantian; Liang, Yingfan; Yang, Tingyuan; Wang, Rui; Zhu, Lili; Li, Honglin] East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China in 2021, Cited 62. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS). Herein, a series of acrylamide-based novel DHODH inhibitors as potential RA treatment agents were designed and synthesized. 2-Acrylamidobenzoic acid analog 11 was identified as the lead compound for structure-activity relationship (SAR) studies. The replacement of the phenyl group with naphthyl moieties improved inhibitory activity significantly to double-digit nanomolar range. Further structure optimization revealed that an acrylamide with small hydrophobic groups (Me, Cl or Br) at the 2-position was preferred. Moreover, adding a fluoro atom at the 5-position of the benzoic acid enhanced the potency. The optimization efforts led to potent compounds 42 and 53.55 with IC50 values of 41, 44, 32, and 42 nmol/L, respectively. The most potent compound 54 also displayed favorable pharmacokinetic (PK) profiles and encouraging in vivo anti-arthritic effects in a dose-dependent manner. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Zeng, FX; Li, SL; Yang, GT; Luo, YT; Qi, TT; Liang, YF; Yang, TY; Zhang, LT; Wang, R; Zhu, LL; Li, HL; Xu, XY or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Ti-superoxide catalyzed oxidative amidation of aldehydes with saccharin as nitrogen source: synthesis of primary amides WOS:000507289600012 published article about SOLVENT-FREE CONDITIONS; RHINOVIRUS 3C PROTEASE; STRUCTURE-BASED DESIGN; ONE-POT SYNTHESIS; HETEROGENEOUS CATALYST; TITANIUM SUPEROXIDE; CARBOXYLIC-ACIDS; PRIMARY AMINES; ALCOHOLS; AMMONIA in [Kamble, Rohit B.; Mane, Kishor D.; Rupanawar, Bapurao D.; Sudalai, A.; Suryavanshi, Gurunath] CSIR, Natl Chem Lab, Chem Engn & Proc Dev Div, Pune 411008, Maharashtra, India; [Kamble, Rohit B.; Mane, Kishor D.; Rupanawar, Bapurao D.; Sudalai, A.; Suryavanshi, Gurunath] Acad Sci & Innovat Res, Ghaziabad 201002, UP, India; [Korekar, Pranjal] MES Abasaheb Garware Coll, Dept Chem, Pune 411004, Maharashtra, India in 2020, Cited 55. COA of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A new heterogeneous catalytic system (Ti-superoxide/saccharin/TBHP) has been developed that efficiently catalyzes oxidative amidation of aldehydes to produce various primary amides. The protocol employs saccharin as amine source and was found to tolerate a wide range of substrates with different functional groups. Moderate to excellent yields, catalyst reusability and operational simplicity are the main highlights. A possible mechanism and the role of the catalyst in oxidative amidation have also been discussed.

COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Kamble, RB; Mane, KD; Rupanawar, BD; Korekar, P; Sudalai, A; Suryavanshi, G or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Li, J; Zhong, M; Sang, XY; Huang, ZZ in SAGE PUBLICATIONS LTD published article about HIGH OPTICAL TRANSPARENCY; AROMATIC POLYAMIDES; ORGANOSOLUBLE POLYAMIDES; LIGHT COLOR; UNITS; LINKAGES in [Li, Juan; Zhong, Ming; Sang, Xiao-Yan; Huang, Zhen-Zhong] Jiangxi Normal Univ, Key Lab Funct Small Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China in 2021, Cited 24. COA of Formula: C14H10O. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8

10,10-Bis[4-(4-aminophenoxy)-3-methylphenyl]-9(10H)-anthrone, as a new aromatic diamine, was synthesized from 9(10H)-anthrone by three-step procedure. Low-temperature polycondensation of this diamine with various aromatic dicarboxylic acid dichlorides produced a series of new cardo poly(ether amide)s with moderate to high inherent viscosities of 0.86-1.43 dL g(-1)while the weight-average and number-average molecular weights were in the range of 48,600-59,800 and 29,800-35,600 g mol(-1), respectively. All the polymers were readily soluble in polar solvents such asN,N-dimethylacetamide (DMAc),N,N-dimethylformamide,N-methyl-2-pyrrolidinone, dimethyl sulfoxide, and pyridine, and afforded transparent, flexible, and strong films upon casting from DMAc solvent. These polymers had glass transition temperatures of 254-297 degrees C, 10% weight loss temperatures of 493-505 degrees C, and char yields of 61-64% at 800 degrees C in nitrogen. All polymers were amorphous and their films exhibited tensile strength of 80.7-101.4 MPa, elongation at break of 8.0-12.8%, and tensile modulus of 1.9-2.6 GPa. These polymers had low moisture uptake in the range of 2.13-4.02% and high transparency with an ultraviolet-visible absorption cutoff wavelength in the 322-375 nm range.

COA of Formula: C14H10O. About Anthrone, If you have any questions, you can contact Li, J; Zhong, M; Sang, XY; Huang, ZZ or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Computed Properties of C7H8N2O. Kerdphon, S; Jongcharoenkamol, J; Chatwichien, J; Singh, T; Channei, D; Choommongkol, V; Rithchumpon, P; Meepowpan, P in [Kerdphon, Sutthichat; Channei, Duangdao] Naresuan Univ, Dept Chem, Fac Sci, Phitsanulok 65000, Thailand; [Jongcharoenkamol, Jira] Naresuan Univ, Fac Pharmaceut Sci, Dept Pharmaceut Chem & Pharmacognosy, Phitsanulok 65000, Thailand; [Chatwichien, Jaruwan] Chulabhorn Royal Acad, Chulabhorn Grad Inst, Program Chem Sci, Bangkok 10210, Thailand; [Singh, Thishana] Univ Kwazulu Natal, Sch Chem & Phys, Private Bag X54001, ZA-4000 Durban, South Africa; [Choommongkol, Vachira] Maejo Univ, Dept Chem, Fac Sci, Chiang Mai 50290, Thailand; [Rithchumpon, Puracheth; Meepowpan, Puttinan] Chiang Mai Univ, Dept Chem, Fac Sci, Chiang Mai 50200, Thailand; [Rithchumpon, Puracheth; Meepowpan, Puttinan] Chiang Mai Univ, Grad Sch, Chiang Mai 50200, Thailand; [Meepowpan, Puttinan] Chiang Mai Univ, Ctr Excellence Mat Sci & Technol, Chiang Mai 50200, Thailand published Microwave-Assisted Green Synthesis of 2,3-Dihydroquinazolinones under Base- and Catalyst-Free conditions in 2021, Cited 47. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

A facile and green one-pot synthesis of 2,3-dihydroquinazolinones, using microwave irradiation, has been developed. Dihydroquinazolinones were synthesized from 2-aminobenzamide derivatives and various aldehydes in aqueous solution under base and catalyst free reaction conditions. The desired products, from aliphatic and aromatic aldehydes substrates, were obtained in 5 minutes with up to 99 % isolated yields.

Computed Properties of C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Kerdphon, S; Jongcharoenkamol, J; Chatwichien, J; Singh, T; Channei, D; Choommongkol, V; Rithchumpon, P; Meepowpan, P or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Environmental Sciences & Ecology very interesting. Saw the article Effect of meteorological factors on scarlet fever incidence in Guangzhou City, Southern China, 2006-2017 published in 2019. Computed Properties of C10H12O3, Reprint Addresses Li, TG (corresponding author), Guangzhou Ctr Dis Control & Prevent, Baiyun Dist Qi Rd, Guangzhou 510440, Guangdong, Peoples R China.. The CAS is 104-21-2. Through research, I have a further understanding and discovery of 4-Methoxybenzyl acetate

Objective: To explore the relationship between meteorological factors and scarlet fever incidence from 2006 to 2017 in Guangzhou, the largest subtropical city of Southern China, and assist public health prevention and control measures. Methods: Data for weekly scarlet fever incidence and meteorological variables from 2006 to 2017 in Guangzhou were collected from the National Notifiable Disease Report System (NNDRS) and the Guangzhou Meteorological Bureau (GZMB). Distributed lag nonlinear models (DLNMs) were conducted to estimate the effect of meteorological factors on weekly scarlet fever incidence in Guangzhou. Results: We observed nonlinear effects of temperature, relative humidity, and wind velocity. The risk was the highest when the weekly mean temperature was 31 degrees C during lag week 14, yielding a relative risk (RR) of 1.48 (95% CI: 1.01-2.17). When relative humidity was 43.5% during lag week 0, the RR was 1.49 (95% CI: 1.04-2.12); the highest RR (1.55, 95% CI: 1.20-1.99) was reached when relative humidity was 93.5% during lag week 20. When wind velocity was 4.4 m/s during lag week 13, the RR was highest at 3.41 (95% CI: 1.57-7.44). Positive correlations were observed among weekly temperature ranges and atmospheric pressure with scarlet fever incidence, while a negative correlation was detected with aggregate rainfall. The cumulative extreme effect of meteorological variables on scarlet fever incidence was statistically significant, except for the high effect of wind velocity. Conclusion: Weekly mean temperature, relative humidity, and wind velocity had double-trough effects on scarlet fever incidence; high weekly temperature range, high atmospheric pressure, and low aggregate rain fall were risk factors for scarlet fever morbidity. Our findings provided preliminary, but fundamental, information that may be useful for a better understanding of epidemic trends of scarlet fever and for developing an early warning system. Laboratory surveillance for scarlet fever should be strengthened in the future. (C) 2019 Elsevier B.V. All rights reserved.

About 4-Methoxybenzyl acetate, If you have any questions, you can contact Lu, JY; Chen, ZQ; Liu, YH; Liu, WH; Ma, Y; Li, TG; Zhang, ZB; Yang, ZC or concate me.. Computed Properties of C10H12O3

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2019 BIOORG CHEM published article about ACID-BINDING PROTEIN; LINEAR-REGRESSION; CELL-GROWTH; QSAR; EXPRESSION; PLS; DISCOVERY; PROSTATE; DESIGN; POTENT in [Floresta, Giuseppe; Spampinato, Ambra; Zagni, Chiara; Rescifina, Antonio] Univ Catania, Dept Drug Sci, Vle A Doria 6, I-95125 Catania, Italy; [Floresta, Giuseppe] Univ Catania, Dept Chem Sci, Vle A Doria, I-95125 Catania, Italy; [Floresta, Giuseppe; Cilibrizzi, Agostino] Kings Coll London, Inst Pharmaceut Sci, Stamford St, London SE1 9NH, England; [Cilibrizzi, Agostino; Abbate, Vincenzo] Kings Coll London, Sch Populat Hlth & Environm Sci, Kings Forens, Franklin Wilkins Bldg,150 Stamford St, London SE1 9NH, England in 2019, Cited 68. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Category: thiomorpholine

Following on the recent publication of pharmacologically relevant effects, small molecule inhibitors of adipocyte fatty-acid binding protein 4 (FABP4) have attracted high interest. FABP4 is mainly expressed in macrophages and adipose tissue, where it regulates fatty acid storage and lipolysis, being also an important mediator of inflammation. In this regard, FABP4 recently demonstrated an interesting molecular target for the treatment of type 2 diabetes, other metabolic diseases and some type of cancers. In the past years, hundreds of effective FABP4 inhibitors have been synthesized. In this paper, a quantitative structure-activity relationship (QSAR) model has been produced, in order to predict the bioactivity of FABP4 inhibitors. The methodology has been combined with a scaffold-hopping approach, allowing to identify three new molecules that act as effective inhibitors of this protein. These molecules, synthesized and tested for their FABP4 inhibitor activity, showed IC(50 )values between 3.70 and 5.59 mu M, with a high level of agreement with the predicted values.

About 2-Aminobenzamide, If you have any questions, you can contact Floresta, G; Cilibrizzi, A; Abbate, V; Spampinato, A; Zagni, C; Rescifina, A or concate me.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Safety of 3-Nitrobenzaldehyde. Authors Luo, J; Ying, LF; Zhang, F; Zhou, Z; Zhang, YG in AMER CHEMICAL SOC published article about in [Luo, Jian; Ying, Lv-Fang; Zhang, Feng] Ningbo Hangzhou Bay Hosp, Dept Orthopaed, Ningbo 315336, Zhejiang, Peoples R China; [Zhou, Ze; Zhang, Yan-Guo] Qiqihar Med Univ, Dept Neurosurg, Qiqihar 161006, Heilongjiang, Peoples R China in 2021.0, Cited 31.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

A novel metal-organic framework (MOF) has been produced via Cu(NO3)(2)center dot 6H(2)O reaction with 3-(1H-tetrazol-5-yl)pyridine (HL) in water, and its chemical formula is {[(Cu-(L)(2)(H2O)(2)] (H2O)(8))(n)}. Due to its high density of coordinately unsaturated sites along with large one-dimensional (1D) hexagonal channels, the activated complex 1 (1a) was explored as the solvent-free heterogeneous catalyst for cyanosilylation under mind conditions. The inhibitory function of compound 1a against the survival rate of OS-732 osteosarcoma cells was evaluated via Cell Counting Kit-8 (CCK-8) detection kit. Furthermore, the Annexin V-FITC/PI detection kit and the active oxygen (ROS) detection kit was carried out to determine the cell apoptosis levels and the ROS accumulation in OS-732 osteosarcoma cells after treatment by compound 1a.

Safety of 3-Nitrobenzaldehyde. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Luo, J; Ying, LF; Zhang, F; Zhou, Z; Zhang, YG or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: C7H8N2O. Authors Peng, J; Hu, LD; Chen, MW; Deng, ZH; Peng, YY in GEORG THIEME VERLAG KG published article about in [Peng, Yiyuan] Jiangxi Normal Univ, Minist Educ, Key Lab Small Funct Organ Mol, Nanchang 330022, Jiangxi, Peoples R China; Jiangxi Normal Univ, Key Lab Green Chem, Nanchang 330022, Jiangxi, Peoples R China in 2021, Cited 41. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A highly selective difluoromethylation of quinazolines has been achieved by using commercially available ethyl bromodifluoroacetate as difluorocarbene precursor, providing the corresponding difluoromethyl substituted quinazoline derivatives with up to 83% yield.

COA of Formula: C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Peng, J; Hu, LD; Chen, MW; Deng, ZH; Peng, YY or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Arynes and Their Precursors from Arylboronic Acids via Catalytic C-H Silylation WOS:000467319600089 published article about BENZYNE; INSERTION; GENERATION; PHENOLS in [Devaraj, Karthik; Ingner, Fredric J. L.; Sollert, Carina; Pilarski, Lukasz T.] Uppsala Univ, Dept Chem BMC, Box 576, S-75123 Uppsala, Sweden; [Gates, Paul J.] Univ Bristol, Sch Chem, Cantocks Close, Bristol BS8 1TS, Avon, England; [Orthaber, Andreas] Uppsala Univ, Dept Chem, Angstrom Labs, Box 523, S-75120 Uppsala, Sweden in 2019, Cited 90. COA of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

A new, operationally simple approach is presented to access arynes and their fluoride-activated precursors based on Ru-catalyzed C-H silylation of arylboronates. Chromatographic purification may be deferred until after aryne capture, rendering the arylboronates de facto precursors. Access to various new arynes and their derivatives is demonstrated, including, for the first time, those based on a 2,3-carbazolyne and 2,3-fluorenyne core, which pave the way for novel derivatizations of motifs relevant to materials chemistry.

About 2-Aminobenzamide, If you have any questions, you can contact Devaraj, K; Ingner, FJL; Sollert, C; Gates, PJ; Orthaber, A; Pilarski, LT or concate me.. COA of Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Computed Properties of C13H10O. Authors Foubert, K; Dendooven, E; Theunis, M; Naessens, T; Ivanova, B; Pieters, L; Gilissen, L; Huygens, S; De Borggraeve, W; Lambert, J; Goossens, A; Aerts, O in WILEY published article about in [Foubert, Kenn; Dendooven, Ella; Theunis, Mart; Naessens, Tania; Ivanova, Boryana; Pieters, Luc] Univ Antwerp UA, Dept Pharmaceut Sci, Res Grp Nat Prod & Food Res & Anal NatuRA, Antwerp, Belgium; [Dendooven, Ella; Lambert, Julien; Aerts, Olivier] Univ Hosp Antwerp UZA, Dept Dermatol, Edegem, Belgium; [Dendooven, Ella; Lambert, Julien; Aerts, Olivier] Univ Antwerp, Res Grp Immunol, Infla Med Ctr Excellence, Antwerp, Belgium; [Gilissen, Liesbeth; Huygens, Sara; Goossens, An] Katholieke Univ Leuven, Dept Dermatol, Univ Hosp, Leuven, Belgium; [De Borggraeve, Wim] KU Leuven Chem&Tech, Dept Chem, Leuven, Belgium in 2021.0, Cited 27.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

Background: The reason why patients photosensitized to the drug ketoprofen (KP) may develop severe photoallergic skin reactions to octocrylene (OCT), an organic ultraviolet filter in sunscreens and cosmetics, remains largely unknown. OCT can be synthesized by using unsubstituted benzophenone (BP), a possible human carcinogen. Objectives: To verify if, and to what extent, BP residues are present in OCT-containing consumer products. Methods: The raw material of OCT and 39 skincare products, of which 28 contain OCT, were chemically analysed for the presence of BP by means of liquid chromatography. Results: In the OCT raw material and in all 28 OCT-containing products the presence of BP could be demonstrated, mostly in concentrations above 10 ppm (0.001%), whereas a majority of OCT-free products (8/11, 73%) did not contain BP. Moreover, BP concentrations significantly increased, in a time- and temperature-dependent manner, likely due to the additional degradation of OCT. Conclusion: Photoallergic contact dermatitis from OCT in patients photosensitized to KP might rely on residual BP impurities. Toxicological and ecological studies that evaluate the safety of OCT might also need to consider the concomitant presence of BP.

Computed Properties of C13H10O. About Benzophenone, If you have any questions, you can contact Foubert, K; Dendooven, E; Theunis, M; Naessens, T; Ivanova, B; Pieters, L; Gilissen, L; Huygens, S; De Borggraeve, W; Lambert, J; Goossens, A; Aerts, O or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem