Month: October 2021

Recommanded Product: 99-61-6. Authors Zaiter, J; Hibot, A; Hafid, A; Khouili, M; Neves, CMB; Simoes, MMQ; Neves, MGPMS; Faustino, MAF; Dagci, T; Saso, L; Armagan, G in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about in [Zaiter, Jamila; Hibot, Achraf; Hafid, Abderrafia; Khouili, Mostafa] Univ Sultan Moulay Slimane, Fac Sci & Tech, Lab Chim Organ & Analyt, BP 523, Beni Mellal 23000, Morocco; [Neves, Claudia M. B.; Simoes, Mario M. Q.; Neves, M. Graca P. M. S.; Faustino, M. Amparo F.] Univ Aveiro, Dept Chem, LAQV REQUIMTE, P-3810193 Aveiro, Portugal; [Dagci, Taner] Ege Univ, Fac Med, Dept Physiol, TR-35100 Izmir, Turkey; [Saso, Luciano] Sapienza Univ Rome, Dept Physiol & Pharmacol Vittorio Erspamer, Ple Aldo Moro 5, I-00185 Rome, Italy; [Armagan, Guliz] Ege Univ, Fac Pharm, Dept Biochem, TR-35100 Izmir, Turkey in 2021, Cited 33. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

The loss of neurons is strongly correlated with aging and aging-associated disorders. In this study, cell viability assays and mitochondrial function were performed to evaluate the effect of new spiro-pyrazole derivatives, prepared from aldehydes and 3-amino-1-phenyl-2-pyrazolin-5-one, on neuroprotection in an in vitro model of dopaminergic cell death induced by 1-methyl-4-phenylpyridinium (MPP+). The percentages of neuroprotection by derivatives were found between 21.26% and 52.67% at selected concentrations (10-50 mu M) with compound 4d exerting the best neuroprotective effect. The results show that the studied spiropyrazolones perform important roles in dopaminergic neuroprotection and can be used for potential new therapies in the treatment of neurodegenerative disorders including Parkinson’s disease. (C) 2020 Elsevier Masson SAS. All rights reserved.

About 3-Nitrobenzaldehyde, If you have any questions, you can contact Zaiter, J; Hibot, A; Hafid, A; Khouili, M; Neves, CMB; Simoes, MMQ; Neves, MGPMS; Faustino, MAF; Dagci, T; Saso, L; Armagan, G or concate me.. Recommanded Product: 99-61-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article 2,4-Disubstituted quinazolines targeting breast cancer cells via EGFR-PI3K WOS:000466828400004 published article about BIOLOGICAL EVALUATION; DERIVATIVES; PI3K/AKT/MTOR; GEFITINIB; PATHWAY; DESIGN; GROWTH in [Li, Er-dong; Lin, Qiao; Meng, Ya-qi; Zhang, Lu-ye; Song, Pan-pan; Li, Na; Xin, Jing-chao; Yang, Peng; Bao, Chong-nan; Zhang, Dan-qing; Zhang, Yang; Wang, Ji-kuan; Zhang, Qiu-rong; Liu, Hong-min] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Henan, Peoples R China; [Li, Er-dong; Lin, Qiao; Meng, Ya-qi; Zhang, Lu-ye; Song, Pan-pan; Li, Na; Xin, Jing-chao; Yang, Peng; Bao, Chong-nan; Zhang, Dan-qing; Zhang, Yang; Wang, Ji-kuan; Zhang, Qiu-rong; Liu, Hong-min] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou 450001, Henan, Peoples R China in 2019, Cited 32. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Recommanded Product: 2-Aminobenzamide

A series of novel 2,4-disubstituted quinazolines were synthesized and evaluated for their anti-tumor activity against five human cancer cells (MDA-MB-231, MCF-7, PC-3, HGC-27 and MGC-803) using MIT assay. Among them, compound 9n showed the most potent cytotoxicity against breast cancer cells. Compound 9n also significantly inhibited the colony formation and migration of MDA-MB-231 and MCF-7 cells. Meanwhile, compound 9n induced cell cycle arrest at G1 phase and cell apoptosis, as well as increased accumulation of intracellular ROS. Furthermore, compound 9n exerted anti-tumor effects in vitro via decreasing the expression of anti-apoptotic protein Bcl-2 and increasing the pro-apoptotic protein Bax and p53. Mechanistically, compound 9n markedly decreased p-EGFR and p-PI3K expression, which revealed that compound 9n targeted breast cancer cells via interfering with EGFR-PI3K signaling pathway. Molecular docking suggested that compound 9n could indeed bind into the active pocket of EGFR. All the findings suggest that compound 9n might be a valuable lead compound for anti-tumor agents targeting breast cancer cells. (C) 2019 Elsevier Masson SAS. All rights reserved.

About 2-Aminobenzamide, If you have any questions, you can contact Li, ED; Lin, Q; Meng, YQ; Zhang, LY; Song, PP; Li, N; Xin, JC; Yang, P; Bao, CN; Zhang, DQ; Zhang, Y; Wang, JK; Zhang, QR; Liu, HM or concate me.. Recommanded Product: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: C7H5NO3. In 2021.0 DRUG DEVELOP RES published article about BIOLOGICAL EVALUATION; ANTIOXIDANT in [Iraji, Aida; Edraki, Najmeh; Khoshneviszadeh, Mahsima; Khoshneviszadeh, Mehdi] Shiraz Univ Med Sci, Med & Nat Prod Chem Res Ctr, Shiraz, Iran; [Panahi, Zahra; Khoshneviszadeh, Mehdi] Shiraz Univ Med Sci, Fac Pharm, Dept Med Chem, Shiraz, Iran in 2021.0, Cited 30.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6.

Due to the fact that tyrosinase is responsible for biosynthesis and regulation of melanins and browning food products, tyrosinase inhibitors can be favorable agents in cosmetics and medicinal industries. A series of novel 2-hydroxy-4-methoxybenzohydrazide were designed, synthesized, and their new application as tyrosinase inhibitors was also disclosed. Based on in vitro tyrosinase inhibitory assay, 4d as the strongest inhibitor of tyrosinase with an IC50 value of 7.57 mu M showed approximately 2.5-fold better inhibition than kojic acid as positive control followed by two compounds 4b (IC50 = 8.19 +/- 0.25 mu M) and 4j (IC50 = 8.92 +/- 0.016) which displayed preferable tyrosinase inhibitory activity. Detailed investigations on the mechanism of action of the 4d reported mix type of inhibition. More importantly, molecular modeling assessments proposed the ability of 4d for potential interaction with Cu (metal)-His (residue) within tyrosinase active site. Overall, 4d is a promising candidate for the development of anti-tyrosinase agents.

COA of Formula: C7H5NO3. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Iraji, A; Panahi, Z; Edraki, N; Khoshneviszadeh, M; Khoshneviszadeh, M or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Formula: C13H10O. Authors Mohamed, MG; Elsayed, MH; Elewa, AM; EL-Mahdy, AFM; Yang, CH; Mohammed, AAK; Chou, HH; Kuo, SW in ROYAL SOC CHEMISTRY published article about in [Mohamed, Mohamed Gamal; EL-Mahdy, Ahmed F. M.; Yang, Cheng-Han; Kuo, Shiao-Wei] Natl Sun Yat Sen Univ, Ctr Crystal Res, Dept Mat & Optoelect Sci, Kaohsiung 804, Taiwan; [Mohamed, Mohamed Gamal; Mohammed, Ahmed A. K.] Assiut Univ, Fac Sci, Chem Dept, Assiut 71516, Egypt; [Elsayed, Mohamed Hammad; Elewa, Ahmed M.; Chou, Ho-Hsiu] Natl Tsing Hua Univ, Dept Chem Engn, Hsinchu 30013, Taiwan; [Elsayed, Mohamed Hammad] Al Azhar Univ, Fac Sci, Dept Chem, Cairo 11884, Egypt; [Kuo, Shiao-Wei] Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 807, Taiwan in 2021.0, Cited 71.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

Photoactive conjugated microporous polymers (CMPs) are emerging as porous materials capable of mediating the photocatalytic evolution of H-2 from water. In this study, we synthesized three pyrene-based CMPs (Py-F-CMP, Py-TPA-CMP, Py-TPE-CMP) through Sonogashira-Hagihara cross-couplings of 1,3,6,8-tetraethynylpyrene (Py-T, as a common monomer building block) with 2,7-dibromo-9H-fluorene (F-Br-2), tris(4-bromophenyl)amine (TPA-Br-3), and 1,1,2,2-tetrakis(4-bromophenyl)ethene (TPE-Br-4), respectively, in the presence of Pd(PPh3)(4) in DMF/Et3N. We then characterized the chemical structures, crystallinities, thermal stabilities, surface morphologies, and porosities of these three new CMPs. Brunauer-Emmett-Teller (BET) analyses and tests of photocatalytic H-2 production revealed that Py-TPA-CMP displayed the highest BET surface area (454 m(2) g(-1)), highest total pore volume (0.28 cm(3) g(-1)), highest H-2 evolution rate (19 200 mu mol h(-1) g(-1)), and highest apparent quantum yield (15.3%) when compared with those of Py-F-CMP, Py-TPE-CMP, and other organic porous materials.

Formula: C13H10O. About Benzophenone, If you have any questions, you can contact Mohamed, MG; Elsayed, MH; Elewa, AM; EL-Mahdy, AFM; Yang, CH; Mohammed, AAK; Chou, HH; Kuo, SW or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Chemistry very interesting. Saw the article Framework Copper Catalyzed Oxidative Synthesis of Quinazolinones: A Benign Approach Using Cu-3(BTC)(2)MOF as an Efficient and Reusable Catalyst published in 2020. Recommanded Product: 88-68-6, Reprint Addresses Suresh, P (corresponding author), Madurai Kamaraj Univ, Sch Chem, Dept Nat Prod Chem, Supramol & Catalysis Lab, Madurai 625021, Tamil Nadu, India.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

A benign and straightforward method to access quinazolinones have been developed using easily preparable Cu-3(BTC)(2)MOF as a sustainable solid-Lewis acid catalyst under mild condition. Cu-3(BTC)(2)MOF was prepared and characterized using various analytical tools such as PXRD, FT-IR, SEM, TGA, and ICP-OES. Synthesis of the quinazolinone is catalyzed by the presence of coordinatively unsaturated open Cu(II)sites in Cu-3(BTC)(2)MOF using renewable ethanol as a solvent with minimum copper loading (0.07 mmol) without any harsh reaction condition. A series of substituted quinazolinones were synthesized with good to excellent yields. The efficiency of the present framework copper catalysts was rationalized by comparing with other MOFs and homogeneous catalytic systems. The stability of the catalyst was demonstrated by six consecutive runs and heterogeneity test, which was also evidenced from the technical supports such as PXRD, FT-IR and SEM analyses of the recovered catalyst.

About 2-Aminobenzamide, If you have any questions, you can contact Latha, G; Devarajan, N; Suresh, P or concate me.. Recommanded Product: 88-68-6

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Functionalization of N,N-Dialkylferrocenesulfonamides toward Substituted Derivatives WOS:000644732000014 published article about CHIRAL FERROCENE DERIVATIVES; DIRECTED ORTHO-LITHIATION; MIXED LITHIUM-ZINC; REGIOSELECTIVE FUNCTIONALIZATION; DEPROTONATIVE METALATION; HALOGEN-DANCE; IN-VITRO; PALLADIUM; LIGANDS; ROUTE in [Wen, Min; Erb, William; Mongin, Florence; Roisnel, Thierry; Dorcet, Vincent] Univ Rennes, ISCR Inst Sci Chim Rennes, CNRS, UMR 6226, F-35000 Rennes, Ille & Vilaine, France; [Ivashkevich, Oleg A.; Matulis, Vadim E.] Belarusian State Univ, Res Inst Phys Chem Problems, Minsk 220030, BELARUS; [Halauko, Yury S.] Belarusian State Univ, UNESCO Chair, Minsk 220030, BELARUS in 2021.0, Cited 115.0. Name: Benzophenone. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

Despite the well-established pharmacological properties of aromatic sulfonamides and the interest of introducing ferrocene into drugs, ferrocene sulfonamides have scarcely been studied. General synthetic methods using lithium bases to perform sulfonamide-directed deprotolithiation or the halogen dance reaction are here reported for the functionalization of N,N-dialkylferrocenesulfonamides toward various polysubstituted derivatives. Postfunctionalization of the ferrocenyl iodides by cross-coupling and lithium/iodine exchange reactions were also considered. Finally, the ligand behavior of new ferrocene phosphines in palladium-catalyzed coupling reactions was studied, and the reaction outcomes are viewed in light of DFT calculations.

Name: Benzophenone. About Benzophenone, If you have any questions, you can contact Wen, M; Erb, W; Mongin, F; Halauko, YS; Ivashkevich, OA; Matulis, VE; Roisnel, T; Dorcet, V or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

COA of Formula: C13H10O. Authors Ni, BN; Li, Y; Liu, W; Li, BZ; Li, HK; Yang, YG in ROYAL SOC CHEMISTRY published article about in [Ni, Baining; Li, Yi; Liu, Wei; Li, Baozong; Li, Hongkun; Yang, Yonggang] Soochow Univ, State & Local Joint Engn Lab Novel Funct Polymer, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China; [Li, Hongkun] South China Univ Technol, State Key Lab Luminescent Mat & Devices, Key Lab Luminescence Mol Aggregates Guangdong Pro, Ctr Aggregat Induced Emiss, Guangzhou 510640, Peoples R China in 2021.0, Cited 52.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

Structurally coloured polymer films with circularly polarized luminescence (CPL) properties were prepared by the photopolymerization of cholesteric liquid crystal mixtures doped with aggregation-induced emission (AIE)-active tetraphenylethylene. The films show good CPL performance with the luminescence dissymmetry factor up to 0.58 and enhanced fluorescence efficiency.

About Benzophenone, If you have any questions, you can contact Ni, BN; Li, Y; Liu, W; Li, BZ; Li, HK; Yang, YG or concate me.. COA of Formula: C13H10O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about PARP INHIBITORS; DNA-REPAIR; BRD4; DISCOVERY; LETHALITY; ADAPTER; TUMORS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81922064, 81874290, 81673455, 81573290, U1603123]; project of Science and Technology Department of Sichuan Province [20YYJC3921]. Published in INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES in BEIJING ,Authors: Chang, XS; Sun, DJ; Shi, DF; Wang, G; Chen, YM; Zhang, K; Tan, HD; Liu, J; Liu, B; Ouyang, L. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. Computed Properties of C7H8N2O

This study was aimed to design the first dual-target small-molecule inhibitor co-targeting poly (ADP-ribose) polymerase-1 (PARP1) and bromodomain containing protein 4 (BRD4), which had important cross relation in the global network of breast cancer, reflecting the synthetic lethal effect. A series of new BRD4 and PARP1 dual-target inhibitors were discovered and synthesized by fragment-based combinatorial screening and activity assays that together led to the chemical optimization. Among these compounds, 19d was selected and exhibited micromole enzymatic potencies against BRD4 and PARP1, respectively. Compound 19d was further shown to efficiently modulate the expression of BRD4 and PARP1. Subsequently, compound 19d was found to induce breast cancer cell apoptosis and stimulate cell cycle arrest at G1 phase. Following pharmacokinetic studies, compound 19d showed its antitumor activity in breast cancer susceptibility gene 1/2 (BRCA1/2) wild-type MDA-MB-468 and MCF-7 xenograft models without apparent toxicity and loss of body weight. These results together demonstrated that a highly potent dual-targeted inhibitor was successfully synthesized and indicated that co-targeting of BRD4 and PARP1 based on the concept of synthetic lethality would be a promising therapeutic strategy for breast cancer. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.

Computed Properties of C7H8N2O. About 2-Aminobenzamide, If you have any questions, you can contact Chang, XS; Sun, DJ; Shi, DF; Wang, G; Chen, YM; Zhang, K; Tan, HD; Liu, J; Liu, B; Ouyang, L or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Theoretical study on the reaction of anthracene with sulfate radical and hydroxyl radical in aqueous solution WOS:000487178000063 published article about POLYCYCLIC AROMATIC-HYDROCARBONS; GAS-PHASE REACTIONS; ADVANCED OXIDATION; PHOTOINDUCED TOXICITY; WATER-TREATMENT; RATE CONSTANTS; OH RADICALS; DEGRADATION; PERSULFATE; PHENANTHRENE in [Liu, Wen; Lv, Guochun; Sun, Xiaomin] Shandong Univ, Environm Res Inst, Jinan 250100, Shandong, Peoples R China; [He, Lin] Leibniz Inst Tropospher Res TROPOS, ACD, D-04318 Leipzig, Germany; [Zhang, Chenxi] Binzhou Univ, Coll Biol & Environm Engn, Binzhou 256600, Peoples R China; [Li, Zhiqiang] Shandong Univ, CORE, Qingdao 266237, Shandong, Peoples R China in 2019, Cited 48. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8. Safety of Anthrone

Sulfate radical (SO4 center dot(-)) and hydroxyl radical (center dot OH) generated from persulfate or peroxymonosulfate in AOPs have been widely used in contaminant degradation. Anthracene (ANT) can be decomposed by SO4 center dot(-) and center dot OH. The processes of ANT decomposition were investigated using theoretical calculations in this paper. The initiation reactions of ANT, anthrone, anthraquinone (ATQ) and 1-hydroxylanthraquinone (1-hATQ) by two radicals are studied. The highest free energy barriers of initiation reactions are 22.30 kcal mol(-1) in ATQ + SO4 center dot(-) reaction and 6.84 kcal mol(-1) in ATQ + center dot OH reaction. Comparing the rate constants of initiation reaction through the two radicals at 273-373 K, it can be concluded that SO4 center dot(-) and center dot OH both play important roles on the initiation of ANT and anthrone at lower pH. For ATQ and 1-hATQ, center dot OH is more important than SO4 center dot(-) in the initiation process, which indicates that the indirect influence of SO4 center dot(-) are more significant in the degradation processes of ATQ and 1-hATQ. This study provides theoretical confirmations for the mechanisms of reactions of ANT with SO4 center dot(-) and center dot OH, and evaluates the importance of SO4 center dot(-) and center dot OH according to the reaction rates. The work can give more insight into the degradation of PAHs by radicals.

Safety of Anthrone. About Anthrone, If you have any questions, you can contact Liu, W; Lv, GC; Sun, XM; He, L; Zhang, CX; Li, ZQ or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Computed Properties of C13H10O. Authors Alokour, M; Yilmaz, E in SPRINGER published article about in [Alokour, Mamoon] Al Balqa Appl Univ, Huson Univ Coll, Dept Basic Sci, Irbid, Jordan; [Alokour, Mamoon; Yilmaz, Elvan] Eastern Mediterranean Univ, Fac Arts & Sci, Dept Chem, Via Mersin 10, Famagusta, North Cyprus, Turkey in 2021.0, Cited 34.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

A crosslinked polymer hybrid film, ipn-poly(vinyl cinnamate-graft-2-hydroxy ethyl methacrylate)-v-poly(ethylene glycol dimethacrylate) was synthesized by UV initiation using poly(vinyl cinnamate) (polyVCi), 2-hydroxy ethyl methacrylate (HEMA) monomer and ethylene glycol dimethacrylate (EGDMA) crosslinker. Benzophenone (Ph2CO), was used as the photoinitiator. The synthesis was optimized by changing the concentration of HEMA, Ph2CO, EGDMA, and UV irradiation time. PolyVCi undergoes photocrosslinking by 2+2 photocylo addition while the monomer/crosslinker couple, HEMA/EGDMA, undergoes free radical polymerization and crosslinking to form EGDMA crosslinked polyHEMA. Hence, simultaneous interpenetrating polymer network (IPN) formation occurs. The IPN consists of dual network of photocrosslinked polyVCi and EGDMA crosslinked polyHEMA chains. Grafting of HEMA/EGDMA chains on the polyVCi backbone also occur during network formation. The chemical functionalities present in the polyVCi/polyHEMA/polyEGDMA IPN films obtained were characterized by FTIR and SEM analysis. The contact angle measurements show enhanced wettability of the IPN film compared to polyVCi surface. TGA analysis confirms thermal stability of the films. Swelling behavior of the films examined in water and in ethanol reveals the effects of the chemical natures of polyVCi and polyHEMA as well as that of crosslinking on the hydrophilicity of the film. The films were tested as drug release matrices using flurbiprofen. The drug was loaded into the film matrix during IPN formation under UV irradiation. PolyVCi/polyHEMA/polyEGDMA IPN proved to be a suitable release matrix for flurbiprofen demonstrating controlled release behavior and zero-order release kinetics. The release mechanism was confirmed by its Ritger-Peppas n value (1.00 to 1.42), which indicates super case II release.

Computed Properties of C13H10O. About Benzophenone, If you have any questions, you can contact Alokour, M; Yilmaz, E or concate me.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem