An article Synthesis of new quinazoline-containing hydroxamic acids as potential HDAC/VEGFR inhibitors. Unusual rearrangements with pyrrolidone ring opening and dehydration of 3-N-hydroxyquinazoline fragment containing tetracycles WOS:000502890400008 published article about HISTONE DEACETYLASE INHIBITORS; GROWTH-FACTOR RECEPTOR-2; BIOLOGICAL EVALUATION; DRUG-RESISTANCE; DUAL INHIBITORS; DESIGN; DERIVATIVES; HYBRIDS; HER2; EGFR in [Kolotaev, Anton, V; Osipov, Vasiliy N.; Khachatryan, Derenik S.] Kurchatov Inst, Fed State Unitary Enterprise, Natl Res Ctr Kurchatov, Inst Chem Reagents & High Pur Chem Subst, Bogorodsky Val 3, Moscow 107076, Russia; [Matevosyan, Karine R.] D Mendeleev Univ Chem Technol Russia, Miusskaya Sq 9, Moscow 125047, Russia; [Osipov, Vasiliy N.] Hlth Minist Russia, NN Blokhin NMRC Oncol, Kashirskoye Highway 23, Moscow 115478, Russia in 2019, Cited 32. Application In Synthesis of 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6
Synthesis pathways were developed and new hydroxamic acids were obtained as potential inhibitors of HDAC/VEGFR2, including tetracycles containing quinazolinone fragment as a cap. Further biological testing of the obtained compounds will give an opportunity to estimate the real prospects of the chosen research direction. (C) 2019 Elsevier Ltd. All rights reserved.
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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem