Recently I am researching about EFFICIENT GENERATION; AM1-BCC MODEL; PROTEIN; DEGRADATION; ENANTIOMERS, Saw an article supported by the National Key R&D Program of China [2018YFA0901200]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31870087, 31670111]. Published in WILEY in HOBOKEN ,Authors: Huang, JW; Chen, D; Jiang, JD. The CAS is 64-10-8. Through research, I have a further understanding and discovery of 1-Phenylurea. Name: 1-Phenylurea
The (R)- and (S)-enantiomers of the chiral herbicide napropamide (NAP) show different biological activities and ecotoxicities. These two enantiomers behave differently in the environment due to enantioselective catabolism by microorganisms. However, the molecular mechanisms underlying this enantioselective catabolism remain largely unknown. In this study, the genes (snaH and snpd) involved in the catabolism of NAP were cloned from Sphingobium sp. B2, which was capable of catabolizing both NAP enantiomers. Compared with (R)-NAP, (S)-NAP was much more rapidly transformed by the amidase SnaH, which initially cleaved the amide bonds of (S)/(R)-NAP to form (S)/(R)-2-(1-naphthalenyloxy)-propanoic acid [(S)/(R)-NP] and diethylamine. The alpha-ketoglutarate-dependent dioxygenase Snpd, showing strict stereoselectivity for (S)-NP, further transformed (S)-NP to 1-naphthol and pyruvate. Molecular docking and site-directed mutagenesis analyses revealed that when the (S)-enantiomers of NAP and NP occupied the active sites, the distance between the ligand molecule and the coordination atom was shorter than that when the (R)-enantiomers occupied the active sites, which facilitated formation of the transition state complex. This study enhances our understanding of the preferential catabolism of the (S)-enantiomer of NAP on the molecular level.
Welcome to talk about 64-10-8, If you have any questions, you can contact Huang, JW; Chen, D; Jiang, JD or send Email.. Name: 1-Phenylurea
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem