I found the field of Chemistry; Pharmacology & Pharmacy very interesting. Saw the article Design and synthesis of sinomenine isoxazole derivatives via 1,3-dipolar cycloaddition reaction published in 2021. Product Details of 99-61-6, Reprint Addresses Zhang, KH; Jin, J (corresponding author), Anhui Jianzhu Univ, Sch Mat & Chem Engn, Hefei, Anhui, Peoples R China.; Cheng, J (corresponding author), Anhui Inst Food & Drug Control, Dept Chem, Hefei, Anhui, Peoples R China.. The CAS is 99-61-6. Through research, I have a further understanding and discovery of 3-Nitrobenzaldehyde
A novel structure of sinomenine isoxazole derivatives is synthesised from sinomenine hydrochloride and aromatic aldehydes and requires six steps. 19 target compounds have been obtained in good yields. The sinomenine hydrochloride transforms to 4-alkynyl sinomenine, which is a key intermediate product to synthesise the target sinomenine isoxazole compounds, after a neutralisation reaction with ammonia and substitution reaction with 3-chloropropyne. Another key intermediate product is 1,3-dipole, which can be obtained from aromatic aldehyde. After treatment with hydroxylamine hydrochloride and then sodium carbonate solution, aromatic aldehyde is converted to aldehyde oxime, which reacts with N-chlorosuccinimide (NCS) to afford aryl hydroximino chloride. 1,3-Dipole is eventually formed in situ while triethylamine (TEA) in DMF is added dropwise. Then 4-alkynyl sinomenine is added to provide the sinomenine isoxazole derivative via 1,3-dipolar cycloaddition reaction as the key step. All the target compounds are characterised by melting point, H-1 NMR, C-13 NMR, HRMS and FT-IR spectroscopy.
About 3-Nitrobenzaldehyde, If you have any questions, you can contact Pan, HM; Lu, T; Wu, XD; Gu, CW; Tao, NL; Zhang, B; Wang, A; Chen, GM; Zhang, KH; Cheng, J; Jin, J or concate me.. Product Details of 99-61-6
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem