An article Design, synthesis, in vitro and in silico evaluation of new 3-phenyl-4,5-dihydroisoxazole-5-carboxamides active against drug-resistant mycobacterium tuberculosis WOS:000609153400016 published article about BIOLOGICAL EVALUATION; DISCOVERY; DERIVATIVES; INHIBITORS; MMPL3 in [Gaikwad, Nikhil Baliram; Afroz, Pathan; Nanduri, Srinivas; Yaddanapudi, Venkata Madhavi] Natl Inst Pharmaceut Educ & Res NIPER, Dept Pharmaceut Technol & Proc Chem, Hyderabad 500037, Telangana, India; [Ahmad, Mohammad Naiyaz; Kaul, Grace; Shukla, Manjulika; Dasgupta, Arunava; Chopra, Sidharth] CSIR Cent Drug Res Inst, Div Microbiol, Sitapur Rd,Sect 10, Lucknow 226031, Uttar Pradesh, India; [Ahmad, Mohammad Naiyaz; Kaul, Grace; Dasgupta, Arunava; Chopra, Sidharth] AcSIR Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India in 2021.0, Cited 35.0. Category: thiomorpholine. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6
A new series of 3-phenyl-4,5-dihydroisoxazole-5-carboxamides were designed, synthesized, and evaluated for their potency against Mtb H37Rv. Designed molecules were synthesized by one-pot cycloaddition reaction in good to excellent yields. Anti-Tubercular evaluation of all synthesized derivatives identified 6k to be highly potent (MIC 1 mu g/mL) against Mtb and drug-resistant strains. All potent derivatives were found to be non-toxic when tested against Vero cells. Also, in silico studies were employed to explore the binding patterns of designed compounds to target Mycobacterial membrane protein Large-3. All derivatives exhibited excellent binding patterns with the receptor. The excellent in silico Absorption, Distribution, Metabolism, and Excretion properties and druggability parameters positions these molecules as promising lead candidates for the future development of new drugs to treat drug-resistant Tuberculosis. (C) 2020 Elsevier B.V. All rights reserved.
Category: thiomorpholine. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Gaikwad, NB; Afroz, P; Ahmad, MN; Kaul, G; Shukla, M; Nanduri, S; Dasgupta, A; Chopra, S; Yaddanapudi, VM or concate me.
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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem