I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy very interesting. Saw the article Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold published in 2019. Product Details of 88-68-6, Reprint Addresses Guglielmi, P (corresponding author), Sapienza Univ Rome, Dipartimento Chim & Tecnol Farmaco, Ple A Moro 5, I-00185 Rome, Italy.; Supuran, CT (corresponding author), Univ Firenze, Sect Pharmaceut & Nutraceut Sci, Neurofarba Dept, Via U Schiff 6, I-50019 Florence, Italy.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide
A large library of derivatives based on the scaffold of 2-(benzylsulfinyl)benzoic acid were synthesised and tested as atypical inhibitors against four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). The exploration of the chemical space around the main functional groups led to the discovery of selective hCA IX inhibitors in the micromolar/nanomolar range, thus establishing robust structure-activity relationships within this versatile scaffold. HPLC separation of some selected chiral compounds and biological evaluation of the corresponding enantiomers was performed along with molecular modelling studies on the most active derivatives.
Welcome to talk about 88-68-6, If you have any questions, you can contact Rotondi, G; Guglielmi, P; Carradori, S; Secci, D; De Monte, C; De Filippis, B; Maccallini, C; Amoroso, R; Cirilli, R; Akdemir, A; Angeli, A; Supuran, CT or send Email.. Product Details of 88-68-6
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Thiomorpholine – Wikipedia,
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