HPLC of Formula: C7H8N2O. In 2019 J ENZYM INHIB MED CH published article about DIKETO ACID-DERIVATIVES; INTERFERENCE COMPOUNDS PAINS; DRUG-RESISTANCE MUTATIONS; REVERSE-TRANSCRIPTASE; RNASE-H; ACTIVE-SITE; DUAL INHIBITORS; MOLECULAR MECHANICS; COLORIMETRIC ASSAY; RNA/DNA HYBRID in [Massari, Serena; Desantis, Jenny; Sabatini, Stefano; Manfroni, Giuseppe; Felicetti, Tommaso; Cecchetti, Violetta; Tabarrini, Oriana] Univ Perugia, Dept Pharmaceut Sci, I-06123 Perugia, Italy; [Corona, Angela; Distinto, Simona; Caredda, Alessia; Maccioni, Elias; Tramontano, Enzo] Univ Cagliari, Dept Life & Environm Sci, Cittadella Univ Monserrato, I-09042 Cagliari, Italy; [Desantis, Jenny] Univ Perugia, Dept Chem Biol & Biotechnol, Perugia, Italy; [Pannecouque, Christophe] Katholieke Univ Leuven, Lab Virol & Chemotherapy, Rega Inst Med Res, Leuven, Belgium; [Tramontano, Enzo] CNR, Ist Ric Genet & Biomed, Monserrato, Italy in 2019, Cited 75. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.
The paper focussed on a step-by-step structural modification of a cycloheptathiophene-3-carboxamide derivative recently identified by us as reverse transcriptase (RT)-associated ribonuclease H (RNase H) inhibitor. In particular, its conversion to a 2-aryl-cycloheptathienoozaxinone derivative and the successive thorough exploration of both 2-aromatic and cycloheptathieno moieties led to identify oxazinone-based compounds as new anti-RNase H chemotypes. The presence of the catechol moiety at the C-2 position of the scaffold emerged as critical to achieve potent anti-RNase H activity, which also encompassed anti-RNA dependent DNA polymerase (RDDP) activity for the tricyclic derivatives. Benzothienooxazinone derivative 22 resulted the most potent dual inhibitor exhibiting IC(50)s of 0.53 and 2.90 mu M against the RNase H and RDDP functions. Mutagenesis and docking studies suggested that compound 22 binds two allosteric pockets within the RT, one located between the RNase H active site and the primer grip region and the other close to the DNA polymerase catalytic centre. [GRAPHICS] .
HPLC of Formula: C7H8N2O. Welcome to talk about 88-68-6, If you have any questions, you can contact Massari, S; Corona, A; Distinto, S; Desantis, J; Caredda, A; Sabatini, S; Manfroni, G; Felicetti, T; Cecchetti, V; Pannecouque, C; Maccioni, E; Tramontano, E; Tabarrini, O or send Email.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem