An article Synthesis and biological evaluation of novel indoleamide derivatives as antioxidative and antitumor agents WOS:000512223000001 published article about INDOLE-2-CARBOXAMIDE DERIVATIVES; ALLOSTERIC MODULATORS; AMIDE DERIVATIVES; DESIGN; DISCOVERY; ACID; INHIBITORS; RECEPTOR; FUNCTIONALITIES; ANTICONVULSANT in [Zhang, Zhen; Gu, Ying-Lin; Wang, Zheng-Yang; Wang, Huan-Nan; Chu, Xue-Mei; Zhang, Chun-Yan; Yan, Mao-Cai] Jining Med Univ, Sch Pharm, Shandong, Peoples R China; [Zhao, Yan] Rizhao Cent Hosp, Oncol Dept, Shandong, Peoples R China in 2020, Cited 42. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Name: 2-Aminobenzamide
Novel indole amide derivatives C1-C10 were successfully synthesized and characterized by H-1 NMR, C-13 NMR, IR, MS, and elemental analysis, and their molecular formulas were C14H10N6O, C13H10N4O, C16H13N3O2, C19H14N2O2, C16H11N3OS, C15H13N3O, C12H9N5O, C16H10ClN3OS, C15H17N3O2, and C13H14N2O3, respectively. The primary biological activities of these compounds were evaluated in vitro by the DPPH assay, H2O2-induced oxidative stress injury assay, and cytotoxicity assay. The results indicated that compounds C1, C2, C4, C7, and C9 exhibited DPPH center dot scavenging ability, while C3, C4, C5, and C8 showed potent growth-inhibitory activities against various human tumor cells, including MDA-MB-231, Hela, A549, and HT29. Interestingly, compound C4 showed potent scavenging effects on the DPPH radical and possessed protective effect on H2O2-induced oxidative stress injury in human neuroblastoma SH-SY5Y cells at low concentrations; however, C4 exhibited significant toxicity against four human tumor cells at a higher concentration in all treatments, and the range of IC50 value was 7.91 to 13.35 mu M.
Name: 2-Aminobenzamide. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem