What unique challenges do researchers face in 2-Aminobenzamide

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In 2020 GREEN CHEM published article about PALLADIUM-CATALYZED ALKYLATION; THERMAL OXIDATIVE-DEGRADATION; POLYETHYLENE-GLYCOL; STEREOSELECTIVE-SYNTHESIS; SELECTIVE ALKYLATION; ALPHA-METHYLATION; C(SP(3))-H BONDS; METHANOL; ARYLACRYLAMIDES; HETEROCYCLES in [Kudale, Vishal Suresh; Wang, Jeh-Jeng] Kaohsiung Med Univ, Dept Med & Appl Chem, 100,Shiquan 1st Rd, Kaohsiung 807, Taiwan; [Wang, Jeh-Jeng] Kaohsiung Med Univ Hosp, Dept Med Res, 100 Tzyou 1st Rd, Kaohsiung 807, Taiwan in 2020, Cited 59. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Recommanded Product: 88-68-6

The generation of a methyl carbon source from renewable and cheap sources is challenging. Herein, we describe a novel and an efficient route for methylation and acetylation of aza-heteroarenes using PEG-400 under O-2 and TsOH center dot H2O for the first time by tuning the reaction conditions using a different set of starting materials. The key features of the current protocol are oxidative C-O and C-C bond scission under metal-free conditions with good functional group tolerance, and a broad substrate scope. The potential applicability of the designed methodology was demonstrated for the synthesis of central nervous system (CNS) depressant and anticonvulsant drug molecules by a one-pot strategy.

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Reference:
Thiomorpholine – Wikipedia,
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