An article Base and catalyst-free synthesis of nitrobenzodiazepines via a cascade N-nitroallylation-intramolecular aza-Michael addition involving o-phenylenediamines and nitroallylic acetates WOS:000502887400007 published article about MORITA-BAYLIS-HILLMAN; CONJUGATED NITROALKENES; FUSED FURANS; ACCESS; IMIDAZOLES; AMIDINES; INSOMNIA; SYNTHONS; ADDUCTS in [Nair, Divya K.; Sivanandan, Sudheesh T.; Namboothiri, Irishi N. N.] Indian Inst Technol, Dept Chem, Mumbai 400076, Maharashtra, India; [Kendrekar, Pravin] Cent Univ Technol, Dept Hlth Sci, Unit Drug Discovery Res, Free State CUT, Private Bag X20539, ZA-9300 Bloemfontein, South Africa in 2019, Cited 73. Category: thiomorpholine. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6
A [4+3] annulation of o-phenylenediamines with primary nitroallylic acetates affords nitrobenzodiazepines (NBDZs) in good to excellent yield. The reaction which proceeds in MeOH at room temperature in the absence of any base or catalyst involves a cascade S(N)2 N-nitroallylation-intramolecular aza-Michael addition sequence. In the case of mono-N-arylated o-phenylenediamines and o-aminobenzamides, the reaction stops at the S(N)2 stage affording nitroallylic amines. On the other hand, reaction of o-aminobenzamides with secondary nitroallylic acetates delivers S(N)2′ products. Formation of stable S(N)2 and S(N)2′ products provides insights into the reactivity of primary and secondary nitroallylic acetates and also the mechanism of formation of nitrobenzodiazepines. (C) 2019 Elsevier Ltd. All rights reserved.
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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem