I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy very interesting. Saw the article From cycloheptathiophene-3-carboxamide to oxazinone-based derivatives as allosteric HIV-1 ribonuclease H inhibitors published in 2019. Safety of 2-Aminobenzamide, Reprint Addresses Massari, S (corresponding author), Univ Perugia, Dept Pharmaceut Sci, I-06123 Perugia, Italy.; Tramontano, E (corresponding author), Univ Cagliari, Dept Life & Environm Sci, Cittadella Univ Monserrato, I-09042 Cagliari, Italy.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide
The paper focussed on a step-by-step structural modification of a cycloheptathiophene-3-carboxamide derivative recently identified by us as reverse transcriptase (RT)-associated ribonuclease H (RNase H) inhibitor. In particular, its conversion to a 2-aryl-cycloheptathienoozaxinone derivative and the successive thorough exploration of both 2-aromatic and cycloheptathieno moieties led to identify oxazinone-based compounds as new anti-RNase H chemotypes. The presence of the catechol moiety at the C-2 position of the scaffold emerged as critical to achieve potent anti-RNase H activity, which also encompassed anti-RNA dependent DNA polymerase (RDDP) activity for the tricyclic derivatives. Benzothienooxazinone derivative 22 resulted the most potent dual inhibitor exhibiting IC(50)s of 0.53 and 2.90 mu M against the RNase H and RDDP functions. Mutagenesis and docking studies suggested that compound 22 binds two allosteric pockets within the RT, one located between the RNase H active site and the primer grip region and the other close to the DNA polymerase catalytic centre. [GRAPHICS] .
Safety of 2-Aminobenzamide. Welcome to talk about 88-68-6, If you have any questions, you can contact Massari, S; Corona, A; Distinto, S; Desantis, J; Caredda, A; Sabatini, S; Manfroni, G; Felicetti, T; Cecchetti, V; Pannecouque, C; Maccioni, E; Tramontano, E; Tabarrini, O or send Email.
Reference:
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