SDS of cas: 104-21-2. Recently I am researching about FLUORINATION; REACTIVITY; FLUORIDE; PHENOLS; ENABLES, Saw an article supported by the National Institutes of Health (NIBIB)United States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of Biomedical Imaging & Bioengineering (NIBIB) [5R01EB014354, R01EB029451]; UNC Department of Radiology, Biomedical Research Imaging Center; UNC Lineberger Comprehensive Cancer Center UNC LCCC pilot grant; NSF Graduate Research FellowshipsNational Science Foundation (NSF); American Australian Association. Published in NATURE PUBLISHING GROUP in LONDON ,Authors: Tay, NES; Chen, W; Levens, A; Pistritto, VA; Huang, Z; Wu, ZH; Li, ZB; Nicewicz, DA. The CAS is 104-21-2. Through research, I have a further understanding and discovery of 4-Methoxybenzyl acetate
Nucleophilic aromatic substitution (SNAr) is routinely used to install (19)F(-)and (18)F(-)in aromatic molecules, but is typically limited to electron-deficient arenes due to kinetic barriers associated with C-F bond formation. Here we demonstrate that a polarity-reversed photoredox-catalysed arene deoxyfluorination that operates via cation-radical-accelerated SNAr enables the fluorination of electron-rich arenes with (19)F(-)and (18)F(-)under mild conditions, and thus complements the traditional arene polarity requirements necessary for SNAr-based fluorination. The utility of our radiofluorination strategy is highlighted by short reaction times, compatibility with multiple nucleofuges and high radiofluorination yields, especially that of an important cancer positron emission tomography agent [F-18]5-fluorouracil. Taken together, our fluorination approach enables the development of fluorinated and radiofluorinated compounds that can be difficult to access by classical SNAr strategies, with the potential for use in the synthesis and discovery of positron emission tomography radiopharmaceuticals.
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