Recently I am researching about PHOSPHONEUROFILAMENT HEAVY-CHAIN; IMMUNOGLOBULIN-G; FC; ANTIBODIES; DIAGNOSIS; GLYCANS; NEUROINFLAMMATION; GALACTOSYLATION; NEUROFILAMENTS; ASSOCIATION, Saw an article supported by the EU JPND project SOPHIA, Fundacao para a Ciencia e a Tecnologia (FCT) [JPND/0003/2011]; Portugal and Euronanomed 2 ERA-NET project GlioEx, FCT, Portugal [ENMed/0001/2013]; iNOVA4Health Research Unit [LISBOA-01-0145-FEDER-007344]; FCT/Ministerio da Ciencia e do Ensino Superior; FEDER under the PT2020 Partnership Agreement. Published in SPRINGER in NEW YORK ,Authors: Costa, J; Streich, L; Pinto, S; Pronto-Laborinho, A; Nimtz, M; Conradt, HS; de Carvalho, M. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. Category: thiomorpholine
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease for which the existing candidate biomarkers (neurofilaments) have low specificity. Changes in blood IgG N-glycosylation have been observed in several diseases, including ALS, whereas cerebrospinal fluid (CSF) IgG has been less studied. Here, we characterized N-glycans of CSF IgG from ALS patients in comparison with a control group of other neurological diseases. Cerebrospinal fluid was collected from patients with ALS (n=26) and other neurological diseases (n=10). N-Glycans were released from CSF purified IgG with peptide N-glycosidase F, labeled with 2-aminobenzamide and analyzed by NP-HPLC chromatography in combination with exoglycosidase digestion and MALDI-TOF mass spectrometry. The N-glycosylation profile of ALS CSF IgG consisted of diantennary N-glycans predominantly with proximal fucose and some bisecting GlcNAc; agalacto-, mono-, and digalactosylated as well as alpha 2,6-sialylated structures were detected. Differences between ALS and control patients were observed; most relevant was the increase in ALS CSF IgG of the level of galactosylated structures defined here as Gal-index (median 46.87 and 40.50% for ALS and controls, respectively; p=0.006). The predictive value of the Gal-index (AUC=0.792, p=0.007) considering ROC analysis had potential utility as a diagnostic test for ALS and was comparable to that of phosphoneurofilament heavy chain (AUC=0.777, p=0.011), which was used as benchmark marker for our group of patients. The results provide the basis to further explore the potential of IgG N-glycan galactosylation as biomarker for ALS by using larger cohorts of patients and controls.
Welcome to talk about 88-68-6, If you have any questions, you can contact Costa, J; Streich, L; Pinto, S; Pronto-Laborinho, A; Nimtz, M; Conradt, HS; de Carvalho, M or send Email.. Category: thiomorpholine
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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem