Month: December 2021

Synthetic Route of 1159408-61-3. Today I’d like to introduce a new chemical compound, CAS is 1159408-61-3, Name is 4-(((3R,5S)-1-(1-(((2R,3R,4R,5R,6R)-3-Acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-16,16-bis((3-((3-(5-(((2R,3R,4R,5R,6R)-3-acetamido-4,5-diacetoxy-6-(acetoxymethyl)tetrahydro-2H-pyran-2-yl)oxy)pentanamido)propyl)amino)-3-oxopropoxy)methyl)-5,11,18-trioxo-14-oxa-6,10,17-triazanonacosan-29-oyl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)pyrrolidin-3-yl)oxy)-4-oxobutanoic acid, Formula is C121H179N11O45, Molecular Weight is 2507.76g/mol. Because of its complex structure and huge molecular weight, this compound is rarely understood. Now let me introduce some knowledge about its synthesis.

The general reactant of this compound is 5-[[3,4,6-Tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentanoic acid;Phenylmethyl N-[2-[3-[(3-aminopropyl)amino]-3-oxopropoxy]-1,1-bis[[3-[(3-aminopropyl)amino]-3-oxopropoxy]methyl]ethyl]carbamate, Reagents is 1-Hydroxybenzotriazole, Diisopropylethylamine;1-[Bis(dimethylamino)methylene]-1H-benzotriazolium hexafluorophosphate(1-) 3-oxide, Catalyst(), Solvent is Dimethylformamide, Products Phenylmethyl 8,14-dioxo-3,3-bis[[3-oxo-3-[[3-[[1-oxo-5-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]pentyl]amino]propyl]amino]propoxy]methyl]-18-[[3,4,6-tri-O-acetyl-2-(acetylamino)-2-deoxy-β-D-galactopyranosyl]oxy]-5-oxa-2,9,13-triazaoctadecanoate, Yield: 58%, Synthetic Methods procedure :1. Add HOBt ( 25.00 g, 0.16 mmol ) and HBTU ( 75.15 g, 198.15 mmol ) to a solution of triamine ( 35.0 g, 54 mmol ) and the acid ( 80.54 g, 180.10 mmol ) in DMF ( 300 mL ) ., 2. Add DIEA ( 94 mL, 544 mmol ) slowly to above mixture., 3. Stir the reaction for 3 hours at room temperature, dilute with water and extract the mixture with ether ( 300 mL ) ., 4. Separate the water phase, extract with DCM ( 2 x 500 mL ) and wash the combined organic layers consecutively with saturated NaHCO3 ( 400 mL ) , water ( 2 x 300 mL ) and brine ( 300 mL ) ., 5. Dry over anhydrous Na2SO4, evaporate the solvent under reduced pressure., 6. Purify the residue by silica gel chromatography ( eluent: 3-15 % MeOH in DCM ) ., Transfornation (Acylation of Nitrogen Nucleophiles by Carboxylic Acids. Characterization Data include ‘s Proton NMR Spectrum : ( 400 MHz, DMSO-d 6 ) : δ 7.87–7.76 ( m, 6H, NH ) ; 7.71 ( t, J = 5.7 Hz, 3H, NH ) ; 7.37-7.25 ( m, 5H ) ; 6.52 ( brs, 1H, NH ) ; 5.20 ( d, J = 3.4 Hz, 3H, sugar H4 ) ; 5.00–4.92 ( m, 5H ) ; 4.47 ( d, J = 8.5 Hz, 3H, sugar H1 ) ; 4.06–3.97 ( m, 9H, sugar H5, H6, H6′ ) ; 3.86 ( dt, J = 8.8, 11.1 Hz, 3H, sugar H2 ) ; 3.69 ( dt, J = 5.6, 9.9 Hz, 3H ) ; 3.53 ( t, J = 6.4 Hz, 6H ) ; 3.47 ( s broad, 6H ) ; 3.39 ( dt, J = 6.4, 9.9 Hz, 3H ) ; 3.07-2.97 ( m, 12H ) ; 2.26 ( t, J = 6.4 Hz, 6H ) ; 2.09 ( s, 9H ) ; 2.03 ( t, J = 7.0 Hz, 6H ) ; 1.98 ( s, 9H ) ; 1.88 ( s, 9H ) ; 1.76 ( s, 9H ) ; 1.58–1.35 ( m, 18H ) ., Carbon-13 NMR : ( 126 MHz, DMSO-d 6 ) : δ171.9, 170.0, 169.9, 169.9, 169.6, 169.4, 137.2, 128.3, 127.7, 127.5, 101.0, 79.2, 70.5, 69.8, 68.7, 68.2, 67.3, 66.7, 61.4, 58.8, 49.4, 36.4, 36.3, 36.1, 35.0, 29.3, 28.6, 22.8, 21.8, 20.5, 20.5, 20.4., Mass Spectrum: Mass calc. for C87H134N10O38: 1926.88; found: 1949.89 [M+Na+, MALDI-TOF, matrix: 2- ( 4-hydroxyphenylazo ) benzoic acid ( HABA ) ]., State is pale yellow solid

Synthetic Route of 1159408-61-3. I’m so glad you had the patience to read the whole article, if you want know more about 1159408-61-3, you can browse my other blog.

Reference:
CAS Reaction Number: 31-355-CAS-9994399,
,CAS Method Number: 3-614-CAS-3165786

Recently I am researching about LIGHT PHOTOCATALYTIC ACTIVITY; PERFORMANCE; ADSORPTION; G-C3N4; NANOSHEETS; DISORDER; ATRAZINE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [22006131, 22076168, 52000158]; Zhejiang Provincial Natural Science Foundation of ChinaNatural Science Foundation of Zhejiang Province [LQ20B070010]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2020T130598, 2019M662106]; Zhejiang University of Technology Startup [2018129007129]; Zhejiang Provincial Ten Thousand Talent Program [2018R52013]. Formula: C13H10O. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhu, C; Shen, Y; Wang, SB; Song, S; Fang, QL; Wang, D; Xu, HM; Liu, RL; He, ZQ. The CAS is 119-61-9. Through research, I have a further understanding and discovery of Benzophenone

Defect engineering of nanomaterials has emerged as a promising approach to improve their performance for pollutant removal. However, various nanomaterial defects play variant roles in environmental applications. It is still a challenge to construct multiple defects of composite materials into advantageous aggregates to deal with complicated matrix pollution. In this work, we investigated a series of three-dimensional defect-optimized aerogels (3D DOAs) of graphene oxide (GO) with a covalent triazine framework (CTF) for improved adsorption and photoregeneration performance via tailoring duet carbon and nitrogen defects. Using chemical reduction, carbon defects in GO were gradually repaired and nitrogen defects in CTF were created simultaneously. The carbon defect engineering generated additional nonpolarized electron-depleted sites in GO of 3D DOA for increased adsorption capacities (2417 mu mol/g for benzophenone, 2209 mu mol/g for 4-hydroxybenzophenone, 1957 mu mol/g for 2,2′,4,4′-tetrahydroxybenzophenone). Meanwhile, increasing nitrogen defects of the CTF in 3D DOA would produce midgap states for an extended absorption range of visible light and increased photocatalytic activity to remove adsorbed pollutants. The enhanced adsorption and the superior photocatalytic regeneration soundly corroborated that the performance of 3D DOA was improved effectively by the defect optimization strategy. Moreover, the high stability of 3D DOA and its practical usage were verified in a real water matrix with a 7-day cycle test. The present work highlights an approach of defect optimization for development of a solar-driven, self-regenerative adsorbent for water purification with high efficiency.

Formula: C13H10O. Welcome to talk about 119-61-9, If you have any questions, you can contact Zhu, C; Shen, Y; Wang, SB; Song, S; Fang, QL; Wang, D; Xu, HM; Liu, RL; He, ZQ or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

SDS of cas: 119-61-9. Authors Wang, YH; Zhao, JW; Xu, F; Zhang, QD; Ai, ZL; Li, BY in WILEY published article about in [Wang, Yuan-Hui; Ai, Zhi-Lu] Henan Agr Univ, Minist Agr & Rural Affairs Peoples Republ China, Key Lab Staple Grain Proc, Zhengzhou, Peoples R China; [Wang, Yuan-Hui; Zhao, Jing-Wen; Xu, Fei; Li, Bo-Yu] Henan Univ Technol, Coll Food Sci & Technol, Zhengzhou, Peoples R China; [Zhang, Qi-Dong] Zhengzhou Tobacco Res Inst CNTC, Zhengzhou, Peoples R China in 2021.0, Cited 31.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

The volatile compounds of Jiaozi-steamed breads (JSBs) fermented by Jiaozi starters from eight regions in China were extracted using simultaneous distillation and extraction (SDE) and headspace solid-phase microextraction and determined using gas chromatography-mass spectrometry (GC-MS). 1-Hexanol, 3-methyl-1-butanol, phenylethyl alcohol, benzaldehyde, naphthalene, ethanol, acetic acid, and n-hexadecanoic acid were the main volatiles of JSBs. Principal component analysis exhibited that the volatiles of JSBs from Nanyang City, Xi’an City, and Zhumadian City was negatively correlated to that of other five JSB samples. Cluster analysis demonstrated that the volatile characteristics of JSBs from Heze City, Minqin County, Taian City, Weinan City, and Yuncheng City belonged to a category, and the JSBs of Nanyang City, Xi’an City, and Zhumadian City were different from other five JSBs. It demonstrated that the volatile components of steamed breads in North China and South China were different. Practical applications From this study, it can be seen that simultaneous distillation and extraction (SDE) can completely extract volatile compositions of steamed breads fermented by Chinese traditional starter Jiaozi. SDE/GC-MS was suitable for the analysis of JSBs volatile composition. The relative contents of 1-hexanol, 3-methyl-1-butanol, phenylethyl alcohol, benzaldehyde, naphthalene, ethanol, acetic acid, and n-hexadecanoic acid in JSBs were at high level, and their contents could be used as a marker to identify JSBs. The volatile compositions of JSBs made of Jiaozi starters from Heze City, Minqin County, Taian City, Weinan City, and Yuncheng City were similar. However, JSBs of Nanyang City, Xi’an City, and Zhumadian City were different from other five JSBs. The volatile components of steamed breads in North China and South China were different, which reflected the difference in dietary habit in the southern and northern areas of China.

SDS of cas: 119-61-9. Bye, fridends, I hope you can learn more about C13H10O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Biliskov, N in AMER CHEMICAL SOC published article about in [Biliskov, Nikola] Rudjer Boskovic Inst, Dept Organ Chem & Biochem, Zagreb 10000, Croatia in 2021.0, Cited 19.0. Name: Benzophenone. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9

Diphenylamine reacts with benzophenone in the solid state through the formation of a eutectic liquid intermediate, from which the final product, in the form of a hydrogen-bonded cocrystal, is finally formed. By a simple experiment, the phase diagram of the benzophenone/diphenylamine system is effectively divided into two parts, which enabled monitoring of the overall process from the side of each reactant separately. Accompanied by isothermal and nonisothermal spectroscopic monitoring of the system, this provides additional details of the mechanistic pathway of the process of cocrystal formation through a metastable liquid intermediate phase.

Welcome to talk about 119-61-9, If you have any questions, you can contact Biliskov, N or send Email.. Name: Benzophenone

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recently I am researching about METAL-ORGANIC FRAMEWORKS; ONE-POT SYNTHESIS; TERMINAL ALKYNES; TANDEM SYNTHESIS; 2-AMINOBENZAMIDES; COMPOSITE; AMINATION; CHEMISTRY; ACIDS, Saw an article supported by the UGCUniversity Grants Commission, India; Science and Engineering Research Board (SERB), New Delhi, India [SR/FT/CS-53/2011]; University Grants Commission, New Delhi, India (UGC)University Grants Commission, India [42-291/2013(SR)]; Council for Scientific and Industrial Research, New Delhi, India (CSIR) [02(0191)14/EMR-II]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Latha, G; Devarajan, N; Suresh, P. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide. Name: 2-Aminobenzamide

A benign and straightforward method to access quinazolinones have been developed using easily preparable Cu-3(BTC)(2)MOF as a sustainable solid-Lewis acid catalyst under mild condition. Cu-3(BTC)(2)MOF was prepared and characterized using various analytical tools such as PXRD, FT-IR, SEM, TGA, and ICP-OES. Synthesis of the quinazolinone is catalyzed by the presence of coordinatively unsaturated open Cu(II)sites in Cu-3(BTC)(2)MOF using renewable ethanol as a solvent with minimum copper loading (0.07 mmol) without any harsh reaction condition. A series of substituted quinazolinones were synthesized with good to excellent yields. The efficiency of the present framework copper catalysts was rationalized by comparing with other MOFs and homogeneous catalytic systems. The stability of the catalyst was demonstrated by six consecutive runs and heterogeneity test, which was also evidenced from the technical supports such as PXRD, FT-IR and SEM analyses of the recovered catalyst.

Name: 2-Aminobenzamide. Welcome to talk about 88-68-6, If you have any questions, you can contact Latha, G; Devarajan, N; Suresh, P or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Chemistry very interesting. Saw the article ompg-C3N4/SO3H: an efficient and recyclable organocatalyst for the facile synthesis of 2,3-dihydroquinazolin-4(1H)-ones published in 2019. Application In Synthesis of 2-Aminobenzamide, Reprint Addresses Ghafuri, H (corresponding author), Iran Univ Sci & Technol, Dept Chem, Catalysts & Organ Synth Res Lab, Tehran 1684613114, Iran.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

In the present work, sulfonated highly ordered mesoporous graphitic carbon nitride (ompg-C3N4/SO3H) was synthesized successfully and employed as an efficient and reusable heterogeneous solid acid catalyst for the rapid and one-pot synthesis of 2,3-dihydroquinazolin-4(1H)-ones via the condensation of anthranilamide with aldehydes or ketones in good to excellent yields. The organocatalyst was characterized by Fourier transform infrared spectroscopy, X-ray diffraction, field emission scanning electron microscopy, energy-dispersive X-ray spectrometer, Brunauer-Emmett-Teller surface area, and thermal gravimetric and differential thermal analysis. The substantial advantages of this procedure involve short reaction times, high catalytic activity, easy workup, high purity of the products, and easy recovery and reusability of the catalyst.

Application In Synthesis of 2-Aminobenzamide. Welcome to talk about 88-68-6, If you have any questions, you can contact Ghafuri, H; Goodarzi, N; Rashidizadeh, A; Fard, MAD or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2019.0 MICROCHIM ACTA published article about PERFORMANCE LIQUID-CHROMATOGRAPHY; ENVIRONMENTAL WATER; GAS-CHROMATOGRAPHY; MILK SAMPLES; MICROEXTRACTION; SPECTROMETRY; CARBON; DIURON; BIOSENSORS; IONS in [Guo, Liying; Hao, Lin; Gao, Tian; Wang, Chun; Wu, Qiuhua; Wang, Zhi] Hebei Agr Univ, Dept Chem, Coll Sci, Baoding 071001, Peoples R China in 2019.0, Cited 34.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8. Formula: C7H8N2O

Graphene oxide was covalently modified with p-phenylenediamine via a diazonium reaction. The resulting material was employed as a sorbent for the solid-phase extraction of six phenylurea herbicides (metoxuron, monuron, chlortoluron, isoproturon, monolinuron, and buturon) from environmental water and lettuce leafs. Some key factors that influence the extraction efficiency were studied, including sample loading rate, sample pH, and desorption conditions. Following desorption with acetonitrile, the analytes were quantified by HPLC with UV detection. Under optimized conditions, response to phenylurea herbicides is linear in the 2.0-100ngmL(-1) concentration range for water samples, and 5.0-100ngg(-1) for leaf lettuces. The limits of detection are 0.10-0.25ngmL(-1) for water samples, and 1.5-2.5ngg(-1) for leaf lettuces. The sorbent was also applied to the preconcentration of organic compounds including nitroimidazoles, chlorophenols, phenylurea insecticides and phthalates. This shows that this sorbent has a large potential for the enrichment of organic pollutants.

Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.. Formula: C7H8N2O

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

HPLC of Formula: C14H10O. In 2020 CHEMISTRYSELECT published article about MESOPOROUS SOLID SUPERBASES; HETEROGENEOUS CATALYSIS; ORGANIC POLYMERS; EFFICIENT; SILICA; NANOPARTICLES; CONVERSION; REDUCTION; STRATEGY; LIQUID in [Lu, Xia; Du, Zhongtian] Dalian Univ Technol, Sch Petr & Chem Engn, Panjin 124221, Peoples R China; [Lu, Xia; Shi, Song; Zhu, Guozhi; Zhao, Li; Wang, Min; Gao, Jin; Xu, Jie] Chinese Acad Sci, State Key Lab Catalysis Dept, Dalian Inst Chem Phys, Dalian Natl Lab Clean Energy, Dalian 116023, Peoples R China; [Zhu, Guozhi; Zhao, Li] Univ Chinese Acad Sci, Beijing 100049, Peoples R China in 2020, Cited 40. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8.

Solid base is a kind of important heterogeneous catalyst for the transformation of various chemicals. Although many different novel solid bases have reported, it is a still challenging process to generate strong basic site on many functional supports due to the high temperature treatment of strong base preparation. In this paper, the strong basic site was successfully generated on hypercrosslinked porous polymers (HCPs) via a reducing group strategy. With the reducing groups on HCPs, the decomposition temperature of base precursor KNO3 could be as low as 320 degrees C. Further investigation illustrated the reducing groups participated in the KNO3 decomposition through a redox strategy. The obtained solid base catalysts showed good oxidation capacity of methylene compounds.

HPLC of Formula: C14H10O. Bye, fridends, I hope you can learn more about C14H10O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

HPLC of Formula: C7H8N2O. In 2019 J ENZYM INHIB MED CH published article about DIKETO ACID-DERIVATIVES; INTERFERENCE COMPOUNDS PAINS; DRUG-RESISTANCE MUTATIONS; REVERSE-TRANSCRIPTASE; RNASE-H; ACTIVE-SITE; DUAL INHIBITORS; MOLECULAR MECHANICS; COLORIMETRIC ASSAY; RNA/DNA HYBRID in [Massari, Serena; Desantis, Jenny; Sabatini, Stefano; Manfroni, Giuseppe; Felicetti, Tommaso; Cecchetti, Violetta; Tabarrini, Oriana] Univ Perugia, Dept Pharmaceut Sci, I-06123 Perugia, Italy; [Corona, Angela; Distinto, Simona; Caredda, Alessia; Maccioni, Elias; Tramontano, Enzo] Univ Cagliari, Dept Life & Environm Sci, Cittadella Univ Monserrato, I-09042 Cagliari, Italy; [Desantis, Jenny] Univ Perugia, Dept Chem Biol & Biotechnol, Perugia, Italy; [Pannecouque, Christophe] Katholieke Univ Leuven, Lab Virol & Chemotherapy, Rega Inst Med Res, Leuven, Belgium; [Tramontano, Enzo] CNR, Ist Ric Genet & Biomed, Monserrato, Italy in 2019, Cited 75. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6.

The paper focussed on a step-by-step structural modification of a cycloheptathiophene-3-carboxamide derivative recently identified by us as reverse transcriptase (RT)-associated ribonuclease H (RNase H) inhibitor. In particular, its conversion to a 2-aryl-cycloheptathienoozaxinone derivative and the successive thorough exploration of both 2-aromatic and cycloheptathieno moieties led to identify oxazinone-based compounds as new anti-RNase H chemotypes. The presence of the catechol moiety at the C-2 position of the scaffold emerged as critical to achieve potent anti-RNase H activity, which also encompassed anti-RNA dependent DNA polymerase (RDDP) activity for the tricyclic derivatives. Benzothienooxazinone derivative 22 resulted the most potent dual inhibitor exhibiting IC(50)s of 0.53 and 2.90 mu M against the RNase H and RDDP functions. Mutagenesis and docking studies suggested that compound 22 binds two allosteric pockets within the RT, one located between the RNase H active site and the primer grip region and the other close to the DNA polymerase catalytic centre. [GRAPHICS] .

HPLC of Formula: C7H8N2O. Welcome to talk about 88-68-6, If you have any questions, you can contact Massari, S; Corona, A; Distinto, S; Desantis, J; Caredda, A; Sabatini, S; Manfroni, G; Felicetti, T; Cecchetti, V; Pannecouque, C; Maccioni, E; Tramontano, E; Tabarrini, O or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

HPLC of Formula: C7H5NO3. Authors Olyaei, A; Adl, A; Vessally, E in SPRINGER published article about in [Olyaei, Abolfazl; Adl, Alireza; Vessally, Esmail] Payame Noor Univ PNU, Dept Chem, PO BOX, Tehran 193954697, Iran in 2021.0, Cited 30.0. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

An efficient and convenient procedure for the synthesis of novel 6-hydroxy-14aryl-8H-dibenzo[a,i]xanthene-8,13(14-H)-dione derivatives has been developed by one-pot, three-component condensation reaction between 2-hydroxynaphthalene-1,4-dione, aromatic aldehydes and 2,3-naphthalenediol in glacial acetic acid under reflux conditions. This domino reaction implies Knoevenagel condensation, Michael addition, intramolecular cyclization and dehydration. The reaction avoids tedious workup procedure due to the direct precipitation of products from the reaction medium. The notable features of this domino transformation are operational simplicity, clean reaction, easy handling, easy purification process and high yields of the products.

Welcome to talk about 99-61-6, If you have any questions, you can contact Olyaei, A; Adl, A; Vessally, E or send Email.. HPLC of Formula: C7H5NO3

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem