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In 2019.0 ACS OMEGA published article about BENZOXAZOLE DERIVATIVES; BIOLOGICAL EVALUATION; DIRECT AMINATION; DESIGN; ANTICANCER; CYANATION in [Slachtova, Veronika; Chasak, Jan; Brulikova, Lucie] Palacky Univ Olomouc, Fac Sci, Dept Organ Chem, 17 Listopadu 12, Olomouc 77146, Czech Republic in 2019.0, Cited 38.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8. Recommanded Product: 64-10-8

This study reports two synthetic approaches leading to 2-aminobenzoxazoles and their N-substituted analogues. Our first synthetic strategy involves a reaction between various o-aminophenols and N-cyano-N-phenyl-p-toluenesulfonamide as a nonhazardous electrophilic cyanating agent in the presence of Lewis acid. The second synthetic approach uses the Smiles rearrangement upon activation of benzoxazole-2-thiol with chloroacetyl chloride. Both developed synthetic protocols are widely applicable, afford the desired aminobenzoxazoles in good to excellent yields, and use nontoxic and inexpensive starting material.

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Reference:
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