Day: January 20, 2022

An article SeO2 Mediated Synthesis of Selected Heterocycles by Oxidative C-C Bond Cleavage of AcetophenoneDerivatives WOS:000474296800027 published article about ONE-POT SYNTHESIS; HIGHLY EFFICIENT; BENZYL ALCOHOLS; METHYL KETONES; BENZIMIDAZOLES; QUINAZOLINONES; BENZOXAZOLES; AMINATION; IODINE; FACILE in [Khan, Danish; Ahmed, Naseem] Indian Inst Technol Roorkee, Dept Chem, Roorkee 247667, Uttarakhand, India; [Alsharif, Meshari A.; Alahmdi, Mohammed Issa; Mukhtar, Sayeed] Univ Tabuk, Fac Sci, Dept Chem, Tabuk 71491, Saudi Arabia in 2019, Cited 66. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Safety of 2-Aminobenzamide

An interestingcyclization reactions of aryl ketones with 2-amino aniline derivatives under SeO2 (oxidant) are described for the synthesis of benzoxazole, benzothiazole, benzimidazole and quinazolinone through the C-C cleavage of acetophenone. The reaction likely involves sequential C-N, C-O and C-S bond formation followed by C(CO)-C(alkyl) bond cleavage. Various substituted fused heterocycles are obtained in good to excellent (gram scale) yields in a single step from readily available acetophenones.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Preparation of High-Performance Polyethylene Composite Materials Reinforced with Cellulose Nanofiber: Simultaneous Nanofibrillation of Wood Pulp Fibers during Melt-Compounding Using Urea and Diblock Copolymer Dispersant WOS:000476966600011 published article about MICROFIBRILLATED CELLULOSE; POLYMER NANOCOMPOSITES; ELASTIC-MODULUS; MECHANICAL-PROPERTIES; CRYSTALLINE REGIONS; SURFACE; GREEN; DISSOLUTION; BIOCOMPOSITES; NANOCELLULOSE in [Sakakibara, Keita; Moriki, Yoshihito; Tsujn, Yoshinobu] Kyoto Univ, Inst Chem Res, Uji, Kyoto 6110011, Japan in 2019.0, Cited 57.0. Application In Synthesis of 1-Phenylurea. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8

Production of nanocomposites from macro-scale materials in situ in a melting compounder is highly desirable yet challenging. In this study, we develop a highly efficient approach for the preparation of cellulose nanofiber (CNF)-reinforced high-density polyethylene (HDPE) composite materials from as-received wood pulp fibers, in which nanofibrillation-assisting plasticizers (urea and urea derivatives) and a diblock copolymer dispersant are used. The most effective plasticizer is urea, which plays a crucial role in producing CNF with less fragmentation during the kneading step, owing to the plasticization/nanofibrillation and the reaction with hydroxyl groups of cellulose fibers into a carbamate. The diblock copolymer as a dispersant enables the stabilization of the appropriate dispersion of the produced CNF in nonpolar HDPE. The resulting composites exhibit significantly improved mechanical properties, including a 6.9-fold increase in the Youngs modulus with 10 wt % loading of wood pulp fibers over that of neat HDPE.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 119-61-9. I found the field of Chemistry very interesting. Saw the article Towards Naked Zinc(II) in the Condensed Phase: A Highly Lewis Acidic Zn-II Dication Stabilized by Weakly Coordinating Carborate Anions published in 2021.0, Reprint Addresses Dagorne, S (corresponding author), Univ Strasbourg, Inst Chim Strasbourg, CNRS, 1 Rue Blaise Pascal, F-67000 Strasbourg, France.; Wehmschulte, RJ (corresponding author), Florida Inst Technol, Chem Program, 150 West Univ Blvd, Melbourne, FL 32901 USA.. The CAS is 119-61-9. Through research, I have a further understanding and discovery of Benzophenone.

The employment of the hexyl-substituted anion [HexCB(11)Cl(11)](-) allowed the synthesis of a Zn-II species, Zn[HexCB(11)Cl(11)](2), 3, in which the Zn2+ cation is only weakly coordinated to two carborate counterions and that is soluble in low polarity organic solvents such as bromobenzene. DOSY NMR studies show the facile displacement of at least one of the counterions, and this near nakedness of the cation results in high catalytic activity in the hydrosilylation of 1-hexene and 1-methyl-1cyclohexene. Fluoride ion affinity (FIA) calculations reveal a solution Lewis acidity of 3 (FIA=262.1 kJ mol(-1)) that is higher than that of the landmark Lewis acid B(C6F5)(3) (FIA=220.5 kJ mol(-1)). This high Lewis acidity leads to a high activity in catalytic CO2 and Ph2CO reduction by Et3SiH and hydrogenation of 1,1-diphenylethylene using 1,4-cyclohexadiene as the hydrogen source. Compound 3 was characterized by multinuclear NMR spectroscopy, mass spectrometry, single crystal X-ray diffraction, and DFT studies.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Synthesis of dibenzocycloketones by acyl radical cyclization from aromatic carboxylic acids using methylene blue as a photocatalyst WOS:000488459900020 published article about PHOTOREDOX CATALYSIS; DEHYDROGENATIVE ARYLATION; INTRAMOLECULAR ACYLATION; LIGHT; ACCESS; FLUORENONES; DERIVATIVES; PYRIDINES; XANTHONE; ARENES in [Jiang, Hongshuo; Mao, Guijie; Wu, Hongfeng; An, Qi; Zuo, Minghui; Guo, Weihao; Xu, Chunzhao; Sun, Zhizhong; Chu, Wenyi] Heilongjiang Univ, Sch Chem & Mat Sci, Harbin 150080, Heilongjiang, Peoples R China; [Jiang, Hongshuo; Wu, Hongfeng; An, Qi; Zuo, Minghui; Guo, Weihao; Xu, Chunzhao; Sun, Zhizhong; Chu, Wenyi] Coll Heilongjiang Prov, Key Lab Chem Engn Proc & Technol High Efficiency, Harbin 150080, Peoples R China in 2019, Cited 61. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8. Product Details of 90-44-8

An efficient intramolecular radical cyclization reaction via photoredox catalysis was developed for the synthesis of dibenzocycloketone derivatives using methylene blue as a photosensitizer. This strategy could be widely used to synthesize large heterocycles due to the unique reactivity of phosphoranyl radicals formed by a polar/SET crossover between an aromatic carboxylic acid and a phosphine radical cation. Attractive features of this process include generation of an acyl radical by an inexpensive and metal-free photocatalyst, which effectively undergoes a cyclization process.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

In 2021.0 BREAST CANCER RES TR published article about PRAVASTATIN; MORTALITY; DISEASE; METAANALYSIS; METABOLISM; ESTROGEN; SURVIVAL; TAIWAN; TRIALS; SAFETY in [Lu, Yin-Che; Chen, Pin-Tzu] Chia Yi Christian Hosp, Ditmanson Med Fdn, Div Hematol Oncol, Chiayi, Taiwan; [Lu, Yin-Che] Min Hwei Jr Coll Hlth Care Management, Tainan, Taiwan; [Huang, Da-Wei] Chia Yi Christian Hosp, Ditmanson Med Fdn, Sect Neurosurg, Dept Surg, Chiayi, Taiwan; [Tsai, Ching-Fang] Chia Yi Christian Hosp, Ditmanson Med Fdn, Dept Med Res, Chiayi, Taiwan; [Lin, Mei-Chen; Lin, Che-Chen] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan; [Lin, Mei-Chen; Lin, Che-Chen; Pan, Yi-Jiun] China Med Univ, Sch Med, Taichung, Taiwan; [Wang, Shi-Heng] China Med Univ, Dept Occupat Safety & Hlth, Taichung, Taiwan; [Wang, Shi-Heng] China Med Univ, Dept Publ Hlth, Taichung, Taiwan in 2021.0, Cited 50.0. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9. Recommanded Product: Benzophenone

Purpose Many studies have revealed that statin therapy reduced mortality in cancer patients, especially in breast cancer, but the effect for second cancer was unclear. We, therefore, performed a comparable cohort study to determine the risk of second cancer in breast cancer patients with statin therapy. Methods Using claims data from Taiwan’s National Health Insurance Program, this study enrolled newly diagnosed breast cancer patients from 2000 to 2007 with and without statin therapy as the statin (n = 1222) and nonstatin (n = 4888) cohorts, respectively. The nonstatin cohort was propensity score matched by cohort entry year, age, and randomly selected comorbidities. These two cohorts were followed up until the diagnosis of second cancer, death, or the end of 2011. Cox proportional hazard models were used to estimate the hazard ratios. Results The statin cohort had a lower incidence rate than the nonstatin cohort for second cancer (7.37 vs. 8.36 per 1000 person-years), although the difference was not significant (adjusted hazard ratio [aHR] 0.90, 95% confidence interval [CI] 0.65-1.26). Compared with the nonstatin cohort, the second cancer risk was significantly higher for patients taking pravastatin (aHR 2.71, 95% CI 1.19-6.19) but lower for those receiving multiple statin treatment (aHR 0.45, 95% CI 0.25-0.81) and combined lipophilic and hydrophilic type of statin (aHR 0.42, 95% CI 0.20-0.89). The risk was lower for patients receiving a cumulative defined daily dose (cDDD) of > 430 (aHR 0.41, 95% CI 0.19-0.86). Conclusion This study showed that there is little association between statin use and second cancer risk in breast cancer patients.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Thondapu, V; Montes, D; Rosovsky, R; Dua, A; McDermott, S; Lu, MT; Ghoshhajra, B; Hoffmann, U; Gerhard-Herman, MD; Hedgire, S in ELSEVIER published article about in [Thondapu, Vikas; Lu, Michael T.; Ghoshhajra, Brian; Hoffmann, Udo; Hedgire, Sandeep] Harvard Med Sch, Massachusetts Gen Hosp, Div Cardiovasc Imaging, Cardiovasc Imaging Res Ctr, 55 Fruit St, Boston, MA 02114 USA; [Montes, Daniel] Harvard Med Sch, Massachusetts Gen Hosp, Div Neuroradiol, Dept Radiol, Boston, MA 02114 USA; [Rosovsky, Rachel] Harvard Med Sch, Massachusetts Gen Hosp, Div Hematol, Dept Med, Boston, MA 02114 USA; [Dua, Anahita] Harvard Med Sch, Massachusetts Gen Hosp, Div Vasc Surg, Dept Rgery, Boston, MA 02114 USA; [McDermott, Shaunagh] Harvard Med Sch, Massachusetts Gen Hosp, Div Thorac Imaging, Dept Radiol, Boston, MA 02114 USA; [Gerhard-Herman, Marie Denise] Harvard Med Sch, Div Cardiovasc Med, Dept Med, Brigham & Womens Hosp, Boston, MA 02114 USA in 2021, Cited 35. HPLC of Formula: C10H12O3. The Name is 4-Methoxybenzyl acetate. Through research, I have a further understanding and discovery of 104-21-2

Objective: Coronavirus disease 2019 (COVID-19) is associated with abnormal inflammatory and coagulation markers, potentially mediating thrombotic events. Our objective was to investigate the incidence, time course, laboratory features, and in-hospital outcomes of COVID-19 patients with suspected venous thromboembolism (VTE). Methods: A retrospective observational cohort study was conducted of patients hospitalized with COVID-19 who had undergone ultrasound imaging for suspected VTE from March 13 to May 18, 2020. The medical records of the included patients were reviewed for D-dimer, fibrinogen, prothrombin time, partial thromboplastin time, platelet count, C-reactive protein (CRP), and high-sensitivity troponin T at admission and at up to seven time points before and after ultrasound examination. The clinical outcomes included superficial venous thrombosis, deep vein thrombosis, pulmonary embolism, intubation, and death. Mixed effects logistic, linear, and Cox proportional hazards methods were used to evaluate the relationships between the laboratory markers and VTE and other in-hospital outcomes. Results: Of 138 patients who had undergone imaging studies, 44 (31.9%) had evidence of VTE. On univariable analysis, an elevated admission CRP (odds ratio [OR], 1.05; 95% confidence interval [CI], 1.01-1.09; P = .02; per 10-U increase in CRP), platelet count (OR, 1.48; 95% CI, 1.04-2.12; P = .03; per 1000-U increase in platelet count), and male sex (OR, 2.64; 95% CI, 1.19-5.84; P = .02), were associated with VTE. However only male sex remained significant on multivariable analysis (OR, 2.37; 95% CI, 1.01-5.56; P = .048). The independent predictors of death included older age (hazard ratio [HR], 1.04; 95% CI, 1.00-1.07; P = .04), active malignancy (HR, 4.39; 95% CI, 1.39-13.91; P = .01), elevated admission D-dimer (HR, 1.016; 95% CI, 1.003-1.029; P = .02), and evidence of disseminated intravascular coagulation (HR, 4.81; 95% CI, 1.76-13.10; P = .002). Conclusions: Male sex, elevated CRP, and elevated platelet count at admission were associated with VTE on univariable analysis. However, only male sex remained significant on multivariable analysis. Older age, active malignancy, disseminated intravascular coagulation, and elevated D-dimer at admission were independently associated with death for patients hospitalized with COVID-19.

HPLC of Formula: C10H12O3. Bye, fridends, I hope you can learn more about C10H12O3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article One-Pot Synthesis of Diverse Collections of Benzoxazepine and Indolopyrazine Fused to Heterocyclic Systems WOS:000456632800044 published article about HOMOFASCAPLYSIN-B; EVODIAMINE; DERIVATIVES; CASCADE; ROUTE; FASCAPLYSIN; INHIBITORS; ALKALOIDS; ACCESS in [Srinivasulu, Vunnam; Sebastian, Anusha; Al-Tel, Taleb H.] Univ Sharjah, Sharjah Inst Med Res, POB 27272, Sharjah, U Arab Emirates; [Shehadeh, Ihsan; Malik, Omar G.] Univ Sharjah, Coll Sci, Dept Chem, POB 27272, Sharjah, U Arab Emirates; [Tarazi, Hamadeh; Baniowda, Nabil; Al-Tel, Taleb H.] Univ Sharjah, Coll Pharm, POB 27272, Sharjah, U Arab Emirates; [Abu-Yousef, Imad A.] Amer Univ Sharjah, Coll Arts & Sci, Dept Biol Chem & Environm Sci, Sharjah, U Arab Emirates; [Khanfar, Monther A.] Univ Jordan, Dept Chem, Amman 11942, Jordan; [O’Connor, Matthew John] New York Univ Abu Dhabi, POB 129188, Abu Dhabi, U Arab Emirates in 2019, Cited 50. HPLC of Formula: C7H8N2O. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

The development of efficient and modular synthetic methods for the synthesis of diverse collection of privileged substructures needed for a drug design and discovery campaign is highly desirable. Benzoxazepine and indolopyrazine ring systems form the core structures of distinct members of biologically significant molecules. Several members of these families have gained attention due to their broad biological activities, which depend on the type of ring-fusion and peripheral substitution patterns. Despite the potential applications of these privileged substructures in drug discovery, efficient, atom economic, and modular strategies for their access are underdeveloped. Herein, a one-step build/couple/pair strategy that uniquely allows access to diversely functionalized benzoxazepine and indolopyrazine scaffolds is described. The methodology features a one-pot combination of condensation, Mannich, oxidation, and aza-Michael addition reactions, employing a variety of functionalized anilines and aldehydes suitably poised with Micheal acceptor. Scandium triflate (Sc(OTf)(3)) in acetonitrile (ACN) was found to promote the construction of benzoxazepines scaffolds, while sodium metabisulfite (Na2S2O5) in aqueous EtOH rapidly enhanced the cascade reaction that led to diverse collections of indolopyrazine frameworks. These protocols represent modular, efficient, and atom-economic access of constrained benzoxazepine and indolopyrazine systems with more than 10 points of diversity and large substrate tolerance.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Name: Anthrone. Abdelkawy, MA; Aly, EA; El-Badawi, MA; Itsuno, S in [Abdelkawy, Mahmoud A.; Itsuno, Shinichi] Toyohashi Univ Technol, Dept Appl Chem & Life Sci, Toyohashi, Aichi 4418580, Japan; [Abdelkawy, Mahmoud A.; Aly, El-Saied A.; El-Badawi, Mahmoud A.] Tanta Univ, Fac Sci, Chem Dept, Tanta 31527, Egypt published Synthesis of Cinchona Urea Polymers and Their Evaluation as Catalyst in the Asymmetric Reactions in 2020, Cited 25. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8.

Chiral polyureas of cinchona alkaloids were synthesized via repetitive Mizoroki-Heck (MH) coupling reaction. The Pd-catalyzed polycondensation of cinchona urea dimers6and aromatic diiodide7afforded the chiral polyureas (P1-P4). The catalytic activity of the chiral polymers was subsequently investigated. The asymmetric Michael addition of ketoesters to nitroolefins was successfully catalyzed by the polymeric organocatalysts (P1-P4) to give the corresponding Michael adducts with high catalytic activities and excellent enantionselectivities (up to >99% ee). The polymeric catalysts were insoluble in commonly used organic solvents. They were easily recovered and reused several times without any loss of the catalytic activity.

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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Matador, E; Iglesias-Siguenza, J; Monge, D; Merino, P; Fernandez, R; Lassaletta, JM in [Lassaletta, Jose M.] US, CSIC, Inst Invest Quim, C Amer Vespucio 49, Seville 41092, Spain; [Lassaletta, Jose M.] CINQA, ORFEO, Ctr Innovac Quim Avanzada, C Amer Vespucio 49, Seville 41092, Spain; [Matador, Esteban; Iglesias-Siguenza, Javier; Monge, David; Fernandez, Rosario] Univ Seville, Dept Quim Organ, C Prof Garcia Gonzalez 1, Seville 41012, Spain; [Matador, Esteban; Iglesias-Siguenza, Javier; Monge, David; Fernandez, Rosario] CINQA, ORFEO, Ctr Innovac Quim Avanzada, C Prof Garcia Gonzalez 1, Seville 41012, Spain; [Merino, Pedro] Univ Zaragoza, CSIC, Inst Biocomputac & Fis Sistemas Complejos BIFI, Zaragoza 50009, Spain published Enantio- and Diastereoselective Nucleophilic Addition of N-tert-Butylhydrazones to Isoquinolinium Ions through Anion-Binding Catalysis in 2021.0, Cited 59.0. Category: thiomorpholine. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6.

A highly enantio- and diastereoselective thiourea-catalyzed dearomatization of isoquinolines employing N-tert-butylhydrazones as neutral alpha-azo carbanions and masked acyl anion equivalents has been developed. Experimental and computational data supports the generation of highly ordered complexes wherein the chloride behaves as a template for the catalyst, the hydrazone reagent, and the isoquinolinium cation, providing excellent stereocontrol in the formation of two contiguous stereogenic centers. The ensuing selective and high-yielding transformations provide appealing dihydroisoquinoline derivatives.

Welcome to talk about 99-61-6, If you have any questions, you can contact Matador, E; Iglesias-Siguenza, J; Monge, D; Merino, P; Fernandez, R; Lassaletta, JM or send Email.. Category: thiomorpholine

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Name: 2-Aminobenzamide. Recently I am researching about ANTICANCER; DISCOVERY; LARGAZOLE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21672061]; National Key Research Program of China [2018YFD0200105, 2017YFD0200505]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities. Published in TAYLOR & FRANCIS LTD in ABINGDON ,Authors: Chen, XL; Zhou, Z; Li, Z; Xu, XY. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

A series of novel 1,2,3-benzotriazin-4-one derivatives containing 4,5-dihydrothiazole-2-thiol were synthesized and characterized by H-1 NMR, C-13 NMR, F-19 NMR and HRMS. The bioassay results showed that compounds 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-7-methoxybenzo[d][1-3]triazin-4(3H)-one, 3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)-6-nitrobenzo[d][1-3]triazin-4(3H)-one, 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1-3]triazin-4(3H)-one exhibited good control efficacy against the cucumber root-knot nematode disease caused by Meloidogyne incognita at the concentration of 10.0 mg L-1 in vivo. Compound 7-chloro-3-(3-((4,5-dihydrothiazol-2-yl)thio)propyl)benzo[d][1-3]triazin-4(3H)-one showed excellent nematicidal activity with inhibition 68.3% at a concentration of 1.0 mg L-1. It suggested that the structure of 1,2,3-benzotriazin-4-one containing 4,5-dihydro-thiazole-2-thiol could be optimized further.

Welcome to talk about 88-68-6, If you have any questions, you can contact Chen, XL; Zhou, Z; Li, Z; Xu, XY or send Email.. Name: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem