Day: January 25, 2022

An article Dihydroquinoline derivative as a potential anticancer agent: synthesis, crystal structure, and molecular modeling studies WOS:000574093800001 published article about INTERMOLECULAR INTERACTIONS; VALIDATION; GENERATION; PREDICTION; INHIBITORS; DISCOVERY; DATABASE; PROGRAM; FAMILY; TOOL in [Vaz, W. F.; Napolitano, H. B.] Univ Estadual Goias, BR-75132400 Anapolis, Go, Brazil; [Vaz, W. F.] Inst Fed Educ Ciencia & Tecnol Mato Grosso, BR-78455000 Lucas Do Rio Verde, MT, Brazil; [Custodio, J. M. F.; D’Oliveira, G. D. C.; Filho, J. T. M.; Perez, C. N.] Univ Fed Goias, BR-74690900 Goiania, Go, Brazil; [Neves, B. J.; Andrade, C. H.] Univ Fed Goias, LabMol, Fac Farm, BR-74605170 Goiania, Go, Brazil; [Junior, P. S. C.] Univ Fed Mato Grosso do Sul, BR-79750000 Nova Andradina, MS, Brazil; [Silveira-Lacerda, E. P.] Univ Fed Goias, Inst Ciencias Biol, Lab Genet Mol & Citogenet, BR-74605170 Goiania, Go, Brazil in 2021.0, Cited 57.0. Name: 3-Nitrobenzaldehyde. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

Cancer is one of the leading causes of death worldwide and requires intense and growing research investments from the public and private sectors. This is expected to lead to the development of new medicines. A determining factor in this process is the structural understanding of molecules with potential anticancer properties. Since the major compounds used in cancer therapies fail to encompass every spectrum of this disease, there is a clear need to research new molecules for this purpose. As it follows, we have studied the class of quinolinones that seem effective for such therapy. This paper describes the structural elucidation of a novel dihydroquinoline by single-crystal X-ray diffraction and spectroscopy characterization. Topology studies were carried through Hirshfeld surfaces analysis and molecular electrostatic potential map; electronic stability was evaluated from the calculated energy of frontier molecular orbitals. Additionally, in silico studies by molecular docking indicated that this dihydroquinoline could act as an anticancer agent due to their higher binding affinity with human aldehyde dehydrogenase 1A1 (ALDH 1A1). Tests in vitro were performed for VERO (normal human skin keratinocytes), B16F10 (mouse melanoma), and MDA-MB-231 (metastatic breast adenocarcinoma), and the results certified that compound as a potential anticancer agent. [GRAPHICS] .

Name: 3-Nitrobenzaldehyde. Welcome to talk about 99-61-6, If you have any questions, you can contact Vaz, WF; Custodio, JMF; D’Oliveira, GDC; Neves, BJ; Junior, PSC; Filho, JTM; Andrade, CH; Perez, CN; Silveira-Lacerda, EP; Napolitano, HB or send Email.

Reference:
Thiomorpholine – Wikipedia,
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Authors Custodio, JMF; D’Oliveira, GDC; Gotardo, F; Cocca, LHZ; de Boni, L; Perez, CN; Napolitano, HB; Osorio, FAP; Valverde, C in ROYAL SOC CHEMISTRY published article about in [Custodio, Jean M. F.; D’Oliveira, Giulio D. C.; Perez, Caridad N.] Univ Fed Goias, Inst Quim, BR-74690970 Goiania, Go, Brazil; [Gotardo, Fernando; Cocca, Leandro H. Z.; de Boni, Leonardo] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13566590 Sao Paulo, SP, Brazil; [Napolitano, Hamilton B.; Valverde, Clodoaldo] Univ Estadual Goias, Campus Ciencias Exatas & Tecnol, BR-75132903 Anapolis, Go, Brazil; [Osorio, Francisco A. P.] Pontificia Univ Catolica Goias, BR-13566590 Goiania, Go, Brazil; [Osorio, Francisco A. P.] Univ Fed Goias, Inst Fis, BR-74690900 Goiania, Go, Brazil; [Valverde, Clodoaldo] Univ Paulista, BR-74845090 Goiania, Go, Brazil in 2021.0, Cited 42.0. Computed Properties of C7H5NO3. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6

In this study, a combined experimental and theoretical study of the nonlinear optical properties (NLO) of two chalcone derivatives, (E)-3-(2-methoxyphenyl)-1-(2-(phenylsulfonylamine)phenyl)prop-2-en-1-one (MPSP) and (E)-3-(3-nitrophenyl)-1-(2-(phenylsulfonylamine)phenyl)prop-2-en-1-one (NPSP), in DMSO is reported. The single crystal structures of the compounds, which differ only by the type and position of one substituent, were grown using the slow evaporation technique, and the main structural differences are discussed. The two-photon absorption and first-order hyperpolarizability measurements were performed via the Z-scan technique and hyper-Rayleigh scattering experiment in DMSO. The theoretical calculations were performed using the Density Functional Theory (DFT) at the CAM-B3LYP/6-311++G(d,p) level, and the sum-over-states (SOS) approach in both static and dynamic cases. Besides the electron conjugation achieved by the aromatic rings, olefins, and carbonyl groups, both compounds have a nearly flat chalcone backbone, which is believed to contribute to the nonlinear optical properties. MPSP and NPSP have different positions, even though they have roughly the same conformation and form C-HMIDLINE HORIZONTAL ELLIPSISO interactions. For several studied frequencies, the HRS first hyperpolarizability values for MPSP are greater than those for NPSP, indicating that in most cases the NLO properties of MPSP are better. The comparison among the theoretical and experimental HRS first hyperpolarizability results showed a good agreement. In addition, the two-dimensional second order nonlinear optical spectra obtained from the sum-over-states model indicate good second-order NLO responses of the two chalcone derivatives under external fields. Our findings are important not only to show the potential nonlinear optical application of the two new compounds but also to gain an insight into how different chemical compositions might affect the crystal structures and physico-chemical properties.

Computed Properties of C7H5NO3. Welcome to talk about 99-61-6, If you have any questions, you can contact Custodio, JMF; D’Oliveira, GDC; Gotardo, F; Cocca, LHZ; de Boni, L; Perez, CN; Napolitano, HB; Osorio, FAP; Valverde, C or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Recommanded Product: 64-10-8. In 2020.0 J MINIM INVAS GYN published article about MULTIPLE IMPUTATION; FLEXIBLE TOOL; WOMEN; HYSTERECTOMY; TRENDS in [Matsushita, Tomomi] Johns Hopkins Bloomberg Sch Publ Hlth, 615 North Wolfe St, Baltimore, MD 21205 USA; [Matsushita, Tomomi; Sekizawa, Akihiko] Showa Univ, Sch Med, Dept Obstet & Gynecol, Tokyo, Japan; [Jacobs, Lisa K.] Dept Surg, Tokyo, Japan; Johns Hopkins Univ, Sch Med, Baltimore, MD USA in 2020.0, Cited 25.0. The Name is 1-Phenylurea. Through research, I have a further understanding and discovery of 64-10-8.

Study Objective: To investigate whether the rate of increase in the performance of abdominal myomectomy over a laparoscopic approach after the US Food and Drug Administration (FDA) safety communication regarding morcellator use for myomectomy differs among races. Design: Retrospective cohort study. Setting: The American College of Surgeons National Surgical Quality Improvement data. Patients: Patients aged 18 to 55 years who underwent either laparoscopic or abdominal myomectomy, excluding malignant cases, emergency cases, operations performed by nongynecologic specialists, and cases in which myomectomy was performed during cesarean section. Interventions: None. Measurements and Main Results: The odds ratios of abdominal myomectomy over laparoscopic myomectomy before and after the release of the FDA communication were calculated in 3 race categories: white, African American, and other races. In a logistic regression analysis adjusted for possible confounders, including all races, the odds ratio of abdominal myomectomy before and after the FDA communication was 1.30 (95% confidence interval [CI], 1.20-1.41; p <. 001). In a logistic regression analysis with a product term of FDA communication exposure and race as a possible effect modifier, the African American population showed a significantly greater change in the odds of abdominal myomectomy over laparoscopic myomectomy in comparison with the white population (1.22; 95% CI, 1.02-1.47; p =.03). In contrast, other races showed no significant change (.83; 95% CI,.64-1.08; p =.17). Conclusion: After the FDA communication, the odds ratio of abdominal myomectomy was disproportionately increased in the African American population. (C) 2019 Published by Elsevier Inc. on behalf of AAGL. Bye, fridends, I hope you can learn more about C7H8N2O, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 64-10-8

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Manganese-catalyzed selective C-H activation and deuteration by means of a catalytic transient directing group strategy WOS:000613880600013 published article about H/D EXCHANGE; FUNCTIONALIZATION; OLEFINS in [Kopf, Sara; Neumann, Helfried; Beller, Matthias] Leibniz Inst Katalyse, Albert Einstein Str 29a, D-18059 Rostock, Germany in 2021, Cited 43. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6. Name: 3-Nitrobenzaldehyde

A novel manganese-catalyzed C-H activation methodology for selective hydrogen isotope exchange of benzaldehydes is presented. Using D2O as a cheap and convenient source of deuterium, the reaction proceeds with excellent functional group tolerance. High ortho-selectivity is achieved in the presence of catalytic amounts of specific amines, which in situ form a transient directing group.

Name: 3-Nitrobenzaldehyde. Welcome to talk about 99-61-6, If you have any questions, you can contact Kopf, S; Neumann, H; Beller, M or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of Anthrone. In 2020 CHEMSUSCHEM published article about C-H OXIDATION; HYDROGEN-PEROXIDE; SELECTIVE OXIDATION; ORGANIC-COMPOUNDS; PHASE OXIDATION; LIQUID-PHASE; ANTHRACENE; OXYGEN; HYDROCARBONS; CYCLOHEXANE in [Jiang, Dabo; Hu, Wenwei; Chen, Mengke; Fu, Zaihui; Su, Anqun; Yang, Bo; Mao, Feng; Zhang, Chao; Liu, Yachun; Yin, Dulin] Hunan Normal Univ, Coll Chem & Chem Engn, Natl & Local Joint Engn Lab New Petrochem Mat & F, Changsha 410081, Hunan, Peoples R China in 2020, Cited 57. The Name is Anthrone. Through research, I have a further understanding and discovery of 90-44-8.

The development of mild and efficient processes for the selective oxygenation of organic compounds by molecular oxygen (O-2) is key for the synthesis of oxygenates. This paper discloses an atom-efficient synthesis protocol for the photo-oxygenation of 9,10-dihydroanthracene (DHA) by O-2 to anthraquinone (AQ), which could achieve quantitative AQ yield (100 %) without any extra catalysts or additives under ambient temperature and pressure. A yield of 86.4 % AQ was obtained even in an air atmosphere. Furthermore, this protocol showed good compatibility for the photo-oxidation of several other compounds with similar structures to DHA. From a series of control experiments, free-radical quenching, and electron paramagnetic resonance spin-trapping results, the photo-oxygenation of DHA was probably initiated by its photoexcited state DHA*, and the latter could activate O-2 to a superoxide anion radical (O-2(.-)) through the transfer of its electron. Subsequently, this photo-oxidation was gradually dominated by the oxygenated product AQ as an active photocatalyst obtained from the oxidation of DHA by O-2(.-), and was accelerated with the rapid accumulation of AQ. The present photo-oxidation protocol is a good example of selective oxygenation based on the photoexcited substrate self-activated O-2, which complies well with green chemistry ideals.

Application In Synthesis of Anthrone. Welcome to talk about 90-44-8, If you have any questions, you can contact Jiang, DB; Hu, WW; Chen, MK; Fu, ZH; Su, AQ; Yang, B; Mao, F; Zhang, C; Liu, YC; Yin, DL or send Email.

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Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Authors Li, YX; Ye, TY; Xu, L; Dong, YH; Luo, Y; Wang, C; Han, YF; Chen, K; Qin, MZ; Liu, YJ; Zhao, YF in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER published article about LEUKEMIA; STRATEGY; SB1518 in [Li, Yingxiu; Ye, Tianyu; Xu, Le; Dong, Yuhong; Luo, Yong; Wang, Chu; Han, Yufei; Chen, Ke; Qin, Mingze; Liu, Yajing; Zhao, Yanfang] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China; [Qin, Mingze] Chinese Peoples Liberat Army Logist Support Forte, Dalian 116021, Peoples R China in 2019, Cited 24. Name: 2-Aminobenzamide. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6

Hybridization strategy is an effective strategy to obtain multi-target inhibitors in drug design. In this study, we assembled the pharmacophores of momelotinib and tandutinib to get a series of 4-piperazinyl-2-aminopyrimidine derivatives. All compounds were tested for the inhibition of JAK2 and FLT3 enzymes, of which, compounds with potent enzyme activities were assayed for antiproliferative activities against three cancer cell lines (HEL, MV4-11, and HL60). The structure-activity relationship studies were conducted through variations in two regions, the A phenyl ring and B phenyl ring. Compound 14j showed the most balanced in vitro inhibitory activity against JAK2 and FLT3 (JAK2 IC50 = 27 nM, FLT3 IC50 = 30 nM), and it also showed potent inhibition against the above tested cell lines. In the cellular context, 14j strongly induced apoptosis by arresting cell cycle in the G(1)/S phase, and was selected as a promising JAK2/FLT3 dual inhibitor. (C) 2019 Elsevier Masson SAS. All rights reserved.

Welcome to talk about 88-68-6, If you have any questions, you can contact Li, YX; Ye, TY; Xu, L; Dong, YH; Luo, Y; Wang, C; Han, YF; Chen, K; Qin, MZ; Liu, YJ; Zhao, YF or send Email.. Name: 2-Aminobenzamide

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

An article Ti-superoxide catalyzed oxidative amidation of aldehydes with saccharin as nitrogen source: synthesis of primary amides WOS:000507289600012 published article about SOLVENT-FREE CONDITIONS; RHINOVIRUS 3C PROTEASE; STRUCTURE-BASED DESIGN; ONE-POT SYNTHESIS; HETEROGENEOUS CATALYST; TITANIUM SUPEROXIDE; CARBOXYLIC-ACIDS; PRIMARY AMINES; ALCOHOLS; AMMONIA in [Kamble, Rohit B.; Mane, Kishor D.; Rupanawar, Bapurao D.; Sudalai, A.; Suryavanshi, Gurunath] CSIR, Natl Chem Lab, Chem Engn & Proc Dev Div, Pune 411008, Maharashtra, India; [Kamble, Rohit B.; Mane, Kishor D.; Rupanawar, Bapurao D.; Sudalai, A.; Suryavanshi, Gurunath] Acad Sci & Innovat Res, Ghaziabad 201002, UP, India; [Korekar, Pranjal] MES Abasaheb Garware Coll, Dept Chem, Pune 411004, Maharashtra, India in 2020, Cited 55. The Name is 2-Aminobenzamide. Through research, I have a further understanding and discovery of 88-68-6. Category: thiomorpholine

A new heterogeneous catalytic system (Ti-superoxide/saccharin/TBHP) has been developed that efficiently catalyzes oxidative amidation of aldehydes to produce various primary amides. The protocol employs saccharin as amine source and was found to tolerate a wide range of substrates with different functional groups. Moderate to excellent yields, catalyst reusability and operational simplicity are the main highlights. A possible mechanism and the role of the catalyst in oxidative amidation have also been discussed.

Category: thiomorpholine. Welcome to talk about 88-68-6, If you have any questions, you can contact Kamble, RB; Mane, KD; Rupanawar, BD; Korekar, P; Sudalai, A; Suryavanshi, G or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

I found the field of Chemistry very interesting. Saw the article Microwave-Assisted Green Synthesis of 2,3-Dihydroquinazolinones under Base- and Catalyst-Free conditions published in 2021. Quality Control of 2-Aminobenzamide, Reprint Addresses Kerdphon, S (corresponding author), Naresuan Univ, Dept Chem, Fac Sci, Phitsanulok 65000, Thailand.. The CAS is 88-68-6. Through research, I have a further understanding and discovery of 2-Aminobenzamide

A facile and green one-pot synthesis of 2,3-dihydroquinazolinones, using microwave irradiation, has been developed. Dihydroquinazolinones were synthesized from 2-aminobenzamide derivatives and various aldehydes in aqueous solution under base and catalyst free reaction conditions. The desired products, from aliphatic and aromatic aldehydes substrates, were obtained in 5 minutes with up to 99 % isolated yields.

Quality Control of 2-Aminobenzamide. Welcome to talk about 88-68-6, If you have any questions, you can contact Kerdphon, S; Jongcharoenkamol, J; Chatwichien, J; Singh, T; Channei, D; Choommongkol, V; Rithchumpon, P; Meepowpan, P or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Formula: C10H12O3. In 2020 BUNDESGESUNDHEITSBLA published article about MENTAL-HEALTH OUTCOMES; ASYLUM SEEKERS; RESIDENCE STATUS; MIGRATION; TRAUMA; IMMIGRANTS; DISORDERS in [Nutsch, Niklas; Bozorgmehr, Kayvan] Univ Bielefeld, Fak Gesundheitswissensch, Bevolkerungsmed & Versorgungsforsch AG2, Postfach 10 01 31, D-33501 Bielefeld, Germany; [Bozorgmehr, Kayvan] Abt Allgemeinmed & Versorgungsforsch, Sekt Hlth Equ Studies & Migrat, Heidelberg, Germany in 2020, Cited 49. The Name is 4-Methoxybenzyl acetate. Through research, I have a further understanding and discovery of 104-21-2.

Background. International studies prove the high burden of mental illnesses among refugees. Postmigration stressors in the country of refugemay affect themental health and result in depression. Objectives. The study examines whether postmigration stressors are associated with the prevalence of depressive symptoms among adult refugees in Germany. Methods. Secondary data analysis based on cross-sectional data of the IAB-BAMF-SOEP Survey of Refugees 2016 (N= 4465) that is representative for Germany. Depressive symptoms were measured using the Patient Health Questionnaire-2 (PHQ-2). Unadjusted and adjusted odds ratios (ORs) and confidence intervals (CIs) were calculated with binary logistic regression models to examine associations between depression and sociodemographic, postmigration, and psychosocial factors. Results. Depressive symptoms show 19.4% of the surveyed refugees. Almost all selected postmigration stressors are significantly associated with depression after adjustment for sociodemographic and psychosocial factors. Unemployment (aOR= 1.48 [1.04-2.12]), loneliness (aOR= 1.14 [1.10-1.18]), and a rejected or undecided asylum application (aOR= 1.34 [1.06-1.70]) increase the odds of depressive symptoms, whereas asylum interviews (aOR= 0.71 [0.56-0.91]) and higher housing satisfaction (aOR= 0.94 [0.91-0.98]) lower the odds of depression. Conclusions. Postmigration stress is associated with the occurrence of depressive symptoms. Sociopolitical interventions considering stressful and protective factors of the postmigration phase can reduce the burden of mental disorders in refugee populations.

Welcome to talk about 104-21-2, If you have any questions, you can contact Nutsch, N; Bozorgmehr, K or send Email.. Formula: C10H12O3

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem

Orooji, Y; Movahedi, A; Liu, ZP; Asadnia, M; Ghasali, E; Ganjkhanlou, Y; Razmjou, A; Karimi-Maleh, H; Kiadeh, NTH in [Orooji, Yasin; Liu, Zhipeng] Nanjing Forestry Univ, Coll Mat Sci & Engn, Nanjing 210037, Jiangsu, Peoples R China; [Orooji, Yasin; Liu, Zhipeng; Ghasali, Ehsan] Nanjing Forestry Univ, Coinnovat Ctr Sustainable Forestry Southern China, Nanjing 210037, Peoples R China; [Movahedi, Ali] Nanjing Forestry Univ, Minist Educ, Key Lab Forest Genet & Biotechnol, Coinnovat Ctr Sustainable Forestry Southern China, Nanjing 210037, Peoples R China; [Asadnia, Mohsen] Macquarie Univ, Sch Engn, Sydney, NSW 2109, Australia; [Ganjkhanlou, Yadolah] Univ Torino, NIS Ctr, Dept Chem, Via P Giuria 7, I-10125 Turin, Italy; [Ganjkhanlou, Yadolah] Univ Torino, INSTM Ctr, Via P Giuria 7, I-10125 Turin, Italy; [Razmjou, Amir] Univ Technol Sydney UTS, Ctr Technol Water & Wastewater CTWW, Sch Civil & Environm Engn, Sydney, NSW, Australia; [Karimi-Maleh, Hassan] Quchan Univ Technol, Lab Nanotechnol, Dept Chem Engn, Quchan, Iran; [Karimi-Maleh, Hassan] Univ Elect Sci & Technol China, Sch Resources & Environm, Xiyuan Ave,POB 611731, Chengdu, Peoples R China; [Karimi-Maleh, Hassan] Univ Johannesburg, Dept Chem Sci, Doornfontein Campus,POB 17011, ZA-2028 Johannesburg, South Africa; [Kiadeh, Naser Tavajohi Hassan] Umea Univ, Chem Biol Ctr, Dept Chem, Tech Chem, S-90187 Umea, Sweden published Luminescent film: Biofouling investigation of tetraphenylethylene blended polyethersulfone ultrafiltration membrane in 2021.0, Cited 47.0. Application In Synthesis of Benzophenone. The Name is Benzophenone. Through research, I have a further understanding and discovery of 119-61-9.

Despite the huge contribution of membrane-based brine and wastewater purification systems in today’s life, biofouling still affects sustainability of membrane engineering. Aimed at reducing membrane modules wastage, the need to study biofouling monitoring as one of contributory factors stemmed from the short time between initial attachment and irreversible biofoulant adhesion. Hence, a membrane for monitoring is introduced to determine the right cleaning time by using fluorescent sensing as a nondestructive and scalable approach. The classical solid-state emissive fluorophore, tetraphenylethylene (TPE), was introduced as a sustainable, safe and sensitive fluorescent indicator in order to show the potential of the method, and polyethersulfone (PES) and non-solvent-induced phase separation method, the most popular material and method, are used to fabricate membrane in industry and academia. Since the employed filler has an aggregation-induced emission (ALE) characteristic, it can track the biofouling throughout the operation. The fabricated membranes have certain characterizations (i.e. morphology assessment, flux, antibiogram, flow cytometry, surface free energy, and protein adsorption) which indicate that hybrid membrane with 5 wt % of TPE has identical biofouling activity compared to neat PES membrane and its optimal luminescence properties make it an appropriate candidate for non-destructive and online biofouling monitoring. (C) 2020 Elsevier Ltd. All rights reserved.

Application In Synthesis of Benzophenone. Welcome to talk about 119-61-9, If you have any questions, you can contact Orooji, Y; Movahedi, A; Liu, ZP; Asadnia, M; Ghasali, E; Ganjkhanlou, Y; Razmjou, A; Karimi-Maleh, H; Kiadeh, NTH or send Email.

Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem