I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article BF3 center dot Et2O as a metal-free catalyst for direct reductive amination of aldehydes with amines using formic acid as a reductant published in 2021.0. Product Details of 99-61-6, Reprint Addresses Xu, LJ (corresponding author), Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China.; Fan, QH (corresponding author), Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China.; Fan, QH (corresponding author), Univ Chinese Acad Sci, Beijing 100190, Peoples R China.. The CAS is 99-61-6. Through research, I have a further understanding and discovery of 3-Nitrobenzaldehyde
A versatile metal- and base-free direct reductive amination of aldehydes with amines using formic acid as a reductant under the catalysis of inexpensive BF3 center dot Et2O has been developed. A wide range of primary and secondary amines and diversely substituted aldehydes are compatible with this transformation, allowing facile access to various secondary and tertiary amines in high yields with wide functional group tolerance. Moreover, the method is convenient for the late-stage functionalization of bioactive compounds and preparation of commercialized drug molecules and biologically relevant N-heterocycles. The procedure has the advantages of simple operation and workup and easy scale-up, and does not require dry conditions, an inert atmosphere or a water scavenger. Mechanistic studies reveal the involvement of imine activation by BF3 and hydride transfer from formic acid.
Product Details of 99-61-6. About 3-Nitrobenzaldehyde, If you have any questions, you can contact Luo, ZL; Pan, YX; Yao, Z; Yang, J; Zhang, X; Liu, XT; Xu, LJ; Fan, QH or concate me.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem