So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Suwinski, Jerzy; Salwinska, Ewa; Watras, Jan; Widel, Maria researched the compound: 1-Methyl-4-nitro-1H-imidazol-5-amine( cas:4531-54-8 ).Name: 1-Methyl-4-nitro-1H-imidazol-5-amine.They published the article 《Nitroimidazoles. VI. Partition coefficients and tautomerism of simple nitroimidazoles》 about this compound( cas:4531-54-8 ) in Acta Poloniae Pharmaceutica. Keywords: nitroimidazole derivative partition coefficient tautomerism. We’ll tell you more about this compound (cas:4531-54-8).
Octanol-water partition coefficients (P) were determined for 42 simple nitroimidazoles with Me, Cl, Br, MeO, NH2, and NO2 substituents. Correlation between log P and the substituent constants πX of Hansch and fX of Nys-Rekker was derived. For the N-methylated compounds, the average value of πN-CH3 was calculated to be -0.30. Significance of log P measurement in estimating the tautomeric equilibrium in 4(5)-nitroimidazoles is discussed in detail.
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Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem