In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Metal-free C(sp3)-H functionalization of sulfonamides via strain-release rearrangement, published in 2021, which mentions a compound: 616-14-8, mainly applied to unsaturated imine preparation diastereoselective chemoselective DFT; fluorotosylamide tosylbenzaldimine carbon hydrogen functionalization strain release rearrangement, Reference of 1-Iodo-2-methylbutane.
A metal-free reaction system that enables C-H bond functionalization of aliphatic sulfonamides R(CH2)2N(F)Ts (R = decyl, cyclohexyl, oxan-4-yl, benzyl, etc.) using DABCO as a promoter under mild conditions, affording a series of α,β-unsaturated imines R1CH=C(R)CH=NTs (R1 = Ph, 4-chlorophenyl, 2,3-dihydro-1-benzofuran-5-yl, etc.) in good yields with high selectivities was presented. This protocol tolerates a broad range of functionalities and can serve as a powerful synthetic tool for the late-stage modification of complex compounds More importantly, control experiments and detailed DFT calculations suggest that this process involves [2 + 2] cyclization/ring-cleavage reorganization, which opens up a new platform for the establishment of other related reorganization reactions.
Compound(616-14-8)Reference of 1-Iodo-2-methylbutane received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(1-Iodo-2-methylbutane), if you are interested, you can check out my other related articles.
Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem