In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Development of a HPLC-DAD stability-indicating method and compatibility study of azathioprine and folic acid as a prerequisite for a monolayer fixed-dose combination, published in 2021, which mentions a compound: 4531-54-8, mainly applied to HPLC stability compatibility azathioprine folic acid monolayer dose combination, SDS of cas: 4531-54-8.
Adherence in chronic diseases is a major problem which can be combated by prescribing fixed-dose combinations in the therapy of the disease. Thus, a combination of azathioprine and folic acid in the treatment of inflammatory bowel disease is highly required, but prior to formulation development, chem. compatibility of the two drugs needs to be investigated. In this work, differential scanning calorimetry, isothermal stress testing, in vitro dissolution and forced degradation studies were utilized to investigate compatibility. Moreover, a stability-indicating HPLC-DAD method for the determination of parent drugs and five of their impurities was developed, validated and applied to the inhouse sample. Compatibility testing revealed no noteworthy interactions of the two drug substances. Furthermore, forced degradation showed no substantial differences between the degradation profiles of each active pharmaceutical ingredient, their mixture and the inhouse sample, further reinforcing the claim of compatibility. Lastly, the inhouse sample was analyzed: it was shown to conform to the requirements of relevant regulatory documents for all the investigated analytes, demonstrating the method’s viability for use in formulation and process development. Our results give way to the possibility of realization of said fixed-dose combination.
In addition to the literature in the link below, there is a lot of literature about this compound(1-Methyl-4-nitro-1H-imidazol-5-amine)SDS of cas: 4531-54-8, illustrating the importance and wide applicability of this compound(4531-54-8).
Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem