Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4531-54-8, is researched, Molecular C4H6N4O2, about Nitroarylamines via the Vicarious Nucleophilic Substitution of Hydrogen: Amination, Alkylamination, and Arylamination of Nitroarenes with Sulfenamides, the main research direction is vicarious nucleophilic substitution nitroarylamine preparation; nitroarylamine preparation; arylamine nitro preparation; amination nitroarene sulfenamide.Reference of 1-Methyl-4-nitro-1H-imidazol-5-amine.
A new reaction of sulfenamides with electrophilic arenes under basic conditions is described. The σ adducts formed from nitroarenes and the anions of sulfenamides undergo elimination of thiol to produce the corresponding o- and/or p-nitroanilines. This reaction is analogous to the known alkylation and hydroxylation of nitroarenes via the vicarious nucleophilic substitution of hydrogen (VNS). The reaction gives access to a wide range of substituted nitroanilines, nitronaphthylamines, and aminoheterocycles. By means of the reaction with N-alkyl- and N-arylsulfenamides, it is possible to obtain N-alkylnitroanilines and nitrodiarylamines. By varying the structure of sulfenamide and the reaction conditions, particularly the nature and concentration of the base, it is possible to control the orientation of amination.
After consulting a lot of data, we found that this compound(4531-54-8)Reference of 1-Methyl-4-nitro-1H-imidazol-5-amine can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem