Wu, Yachuang published the artcileSynthesis and antibacterial activity evaluation of novel biaryloxazolidinone analogues containing a hydrazone moiety as promising antibacterial agents, Synthetic Route of 220655-09-4, the main research area is linezolid hydrazone analog synthesis bactericide; Antibacterial activity; Biaryloxazolidinone; Gram-positive organisms; Hydrazone moiety.
A series of linezolid analogs containing a hydrazone moiety were designed, synthesized and evaluated for their antibacterial activity. Most compounds exhibited more potent antibacterial activity against S. aureus, MRSA, MSSA, LREF and VRE pathogens as compared with linezolid and radezolid. Compounds 9a, 9c, 9f, 9g, 10m and 10t (I – VI, resp.) were more potent against tested clin. isolates of MRSA, MSSA, VRE and LREF as compared to linezolid. Compound 9a (I) exhibited comparable activity with linezolid against human MAO-A for safety evaluation and showed moderate metabolism in human liver microsome. The most promising compound 9a showed remarkable antibacterial activity against S.aureus, MRSA, MSSA, LREF and VRE pathogens with MIC value of 0.0675 mg/mL, resp., which was 15- to 30-fold more potent than linezolid.
European Journal of Medicinal Chemistry published new progress about Antibacterial agents. 220655-09-4 belongs to class thiomorpholine, name is tert-Butyl thiomorpholine-4-carboxylate, and the molecular formula is C9H17NO2S, Synthetic Route of 220655-09-4.
Referemce:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem