The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Iodo-2-methylbutane( cas:616-14-8 ) is researched.Name: 1-Iodo-2-methylbutane.Hartmann, Rolf W.; Batzl, Christine published the article 《Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones》 about this compound( cas:616-14-8 ) in Journal of Medicinal Chemistry. Keywords: aminophenylpiperidinedione preparation antitumor; piperidinedione aminophenyl preparation antitumor; aromatase placental inhibition aminophenylpiperidinedione; desmolase adrenal inhibition aminophenylpiperidinedione; estradiol inhibition aminophenylpiperidinedione. Let’s learn more about this compound (cas:616-14-8).
Piperidinediones I (R = H, Me, Et, Pr, CHMe2, CH2CHMe2, CHMeEt, pentyl, isopentyl, CH2CHMeEt, sec-pentyl, hexyl, heptyl) were prepared by alkylating PhCH2CN, addition reaction of PhCHRCN with CH2:CHCN, hydrolysis and ring closure of NCCRPhCH2CH2CN, nitration, and reduction of the nitro group. In vitro I showed a stronger inhibition of human placental aromatase than aminoglutethimide (II). The most active derivative, I (R = isopentyl), showed a 93-fold stronger inhibition than II. I, except I (R = CHMe2, CH2CHMe2, CHMeEt) exhibited equal or lower inhibition of bovine adrenal desmolase than II. Many I showed a stronger inhibition of the plasma estradiol concentration of pregnant mare serum gonadotropin-primed rats than II. They inhibited the testosterone-stimulated tumor growth of ovariectomized 9,10-dimethyl-1,2-benzanthracene tumor-bearing rats more strongly than II. Being stronger and more selective inhibitors of the estrogen biosynthesis than II, some of the newly developed derivatives of II might be better candidates for the treatment of hormone-dependent human breast cancer.
The article 《Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones》 also mentions many details about this compound(616-14-8)Name: 1-Iodo-2-methylbutane, you can pay attention to it, because details determine success or failure
Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem