Electric Literature of C5H11I. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 1-Iodo-2-methylbutane, is researched, Molecular C5H11I, CAS is 616-14-8, about Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones. Author is Hartmann, Rolf W.; Batzl, Christine.
Piperidinediones I (R = H, Me, Et, Pr, CHMe2, CH2CHMe2, CHMeEt, pentyl, isopentyl, CH2CHMeEt, sec-pentyl, hexyl, heptyl) were prepared by alkylating PhCH2CN, addition reaction of PhCHRCN with CH2:CHCN, hydrolysis and ring closure of NCCRPhCH2CH2CN, nitration, and reduction of the nitro group. In vitro I showed a stronger inhibition of human placental aromatase than aminoglutethimide (II). The most active derivative, I (R = isopentyl), showed a 93-fold stronger inhibition than II. I, except I (R = CHMe2, CH2CHMe2, CHMeEt) exhibited equal or lower inhibition of bovine adrenal desmolase than II. Many I showed a stronger inhibition of the plasma estradiol concentration of pregnant mare serum gonadotropin-primed rats than II. They inhibited the testosterone-stimulated tumor growth of ovariectomized 9,10-dimethyl-1,2-benzanthracene tumor-bearing rats more strongly than II. Being stronger and more selective inhibitors of the estrogen biosynthesis than II, some of the newly developed derivatives of II might be better candidates for the treatment of hormone-dependent human breast cancer.
《Aromatase inhibitors. Synthesis and evaluation of mammary tumor inhibiting activity of 3-alkylated 3-(4-aminophenyl)piperidine-2,6-diones》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Iodo-2-methylbutane)Electric Literature of C5H11I.
Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem