The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 1-Iodo-2-methylbutane( cas:616-14-8 ) is researched.Safety of 1-Iodo-2-methylbutane.Berthold, Dino; Breit, Bernhard published the article 《Total Synthesis of (-)-Cylindrocyclophane F: A Yardstick for Probing New Catalytic C-C Bond-Forming Methodologies》 about this compound( cas:616-14-8 ) in Chemistry – A European Journal. Keywords: cylindrocyclophane F synthesis; C-allylation; Negishi coupling; cylindrocyclophane F; lactic acid; metathesis; total synthesis. Let’s learn more about this compound (cas:616-14-8).
A short and efficient total synthesis of the C2-sym. (-)-cylindrocyclophane F is presented, using a cross olefin metathesis dimerization strategy for construction of the [7,7]-paracyclophane macrocycle. The synthesis of the dimerization building block includes a Pd-catalyzed sp3-sp2 Negishi cross coupling of a sterically hindered Zn-reagent with an aromatic triflate, an enantiospecific Zn-catalyzed sp3-sp3 cross coupling of an α-hydroxy ester triflate with a Grignard reagent and the application of an enantioselective Rh-catalyzed C-allylation of an electron rich arene.
《Total Synthesis of (-)-Cylindrocyclophane F: A Yardstick for Probing New Catalytic C-C Bond-Forming Methodologies》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Iodo-2-methylbutane)Safety of 1-Iodo-2-methylbutane.
Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem