Day: April 21, 2022

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Vital signs: trends in use of long-acting reversible contraception among teens aged 15-19 years seeking contraceptive services—United States, 2005-2013.》. Authors are Romero, Lisa; Pazol, Karen; Warner, Lee; Gavin, Lorrie; Moskosky, Susan; Besera, Ghenet; Loyola Briceno, Ana Carolina; Jatlaoui, Tara; Barfield, Wanda; Centers for Disease Control and Prevention (CDC).The article about the compound:1-Iodo-2-methylbutanecas:616-14-8,SMILESS:CCC(CI)C).COA of Formula: C5H11I. Through the article, more information about this compound (cas:616-14-8) is conveyed.

BACKGROUND: Nationally, the use of long-acting reversible contraception (LARC), specifically intrauterine devices (IUDs) and implants, by teens remains low, despite their effectiveness, safety, and ease of use. METHODS: To examine patterns in use of LARC among females aged 15-19 years seeking contraceptive services, CDC and the U.S. Department of Health and Human Services’ Office of Population Affairs analyzed 2005-2013 data from the Title X National Family Planning Program. Title X serves approximately 1 million teens each year and provides family planning and related preventive health services for low-income persons. RESULTS: Use of LARC among teens seeking contraceptive services at Title X service sites increased from 0.4% in 2005 to 7.1% in 2013 (p-value for trend <0.001). Of the 616,148 female teens seeking contraceptive services in 2013, 17,349 (2.8%) used IUDs, and 26,347 (4.3%) used implants. Use of LARC was higher among teens aged 18-19 years (7.6%) versus 15-17 years (6.5%) (p<0.001). The percentage of teens aged 15-19 years who used LARC varied widely by state, from 0.7% (Mississippi) to 25.8% (Colorado). CONCLUSIONS: Although use of LARC by teens remains low nationwide, efforts to improve access to LARC among teens seeking contraception at Title X service sites have increased use of these methods. IMPLICATIONS FOR PUBLIC HEALTH PRACTICE: Health centers that provide quality contraceptive services can facilitate use of LARC among teens seeking contraception. Strategies to address provider barriers to offering LARC include: 1) educating providers that LARC is safe for teens; 2) training providers on LARC insertion and a client-centered counseling approach that includes discussing the most effective contraceptive methods first; and 3) providing contraception at reduced or no cost to the client. This compound(1-Iodo-2-methylbutane)COA of Formula: C5H11I was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 1-Iodo-2-methylbutane(SMILESS: CCC(CI)C,cas:616-14-8) is researched.SDS of cas: 616-14-8. The article 《Total Synthesis of (-)-Cylindrocyclophane F: A Yardstick for Probing New Catalytic C-C Bond-Forming Methodologies》 in relation to this compound, is published in Chemistry – A European Journal. Let’s take a look at the latest research on this compound (cas:616-14-8).

A short and efficient total synthesis of the C2-sym. (-)-cylindrocyclophane F is presented, using a cross olefin metathesis dimerization strategy for construction of the [7,7]-paracyclophane macrocycle. The synthesis of the dimerization building block includes a Pd-catalyzed sp3-sp2 Negishi cross coupling of a sterically hindered Zn-reagent with an aromatic triflate, an enantiospecific Zn-catalyzed sp3-sp3 cross coupling of an α-hydroxy ester triflate with a Grignard reagent and the application of an enantioselective Rh-catalyzed C-allylation of an electron rich arene.

This compound(1-Iodo-2-methylbutane)Recommanded Product: 616-14-8 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Optical rotations of configurationally related azides》. Authors are Levene, P. A.; Rothen, Alexandre; Kuna, Martin.The article about the compound:1-Iodo-2-methylbutanecas:616-14-8,SMILESS:CCC(CI)C).SDS of cas: 616-14-8. Through the article, more information about this compound (cas:616-14-8) is conveyed.

Substances of the type MeCH[(CH2)n1X][(CH2)n2R], where n1 or n2 = 0 or an integer, X = a functional group and R = a normal alkyl, Ph or C6Hn group, can be classified into 2 categories, viz., those, typified by X = CHO, in which the configuration of the 1st members having n1 = 0 can be correlated by classical methods to those having n1 > 0, and those, typified by X = halogen, in which such correlation cannot be accomplished by classical methods. For the purpose of solving the latter problem the azides were chosen over the halides, inasmuch as they can be converted into the corresponding amines. The amines, while belonging to the 2nd category, can be correlated among themselves by a sufficiently reliable though nonclassical argument which will be reported later. The secondary azides were prepared by the action of NaN3 on the iodides and the amines by reduction of the azides with PtO2. The rotatory phenomena observed in the series of azides and halides were compared with those in the series of aldehydes and were found to be dissimilar in both series. Hence a comparison of these phenomena cannot be used for the correlation of the members of the series of halides and azides having n1 = 0 with those having n1 > 0. The following compounds were prepared: l-2-iodobutane, b. 111-18°, [M]D25 -24.1°, from the alc. and anhydrous HI in a bomb tube at room temperature for 2 days; d-2-azidobutane, b500 85°, d425 0.8619, nD25 1.4122, [M]D25 15.9°; d-2-aminobutane, [M]D25, 0.66° (in H2O), (HCl salt, [M]5875.625 -0.44° (in H2O)); l-2-iodoöctane, b1 52°, nD25 1.4863, d425 1.3158, [M]D25 -80.0°; d-2-azidoöctane, b9 68°, nD25 1.4332, d425 0.8555, [M]D25 43.4°, 42.5° (in heptane (I)); d-2-aminoöctane, b9 48°, nD25 1.4220, [M]D25 5.41°, (HCl salt, [M]D25 -6.44° (in H2O)); d-1-iodo-2-methylbutane, b. 145-6°, nD25 1.4950, [M]D25 8.28°, maximum [M]D25 11.1°; d-1-azido-2-methylbutane, b138 72°, nD25 1.4240, d425 0.8770, [M]D25 8.61°, maximum [M]D25 11.6°; l-1-amino-2-methylbutane, b12 40-5°, [M]5875.625 -0.21° (in H2O); l-1-azido-2-methylhexane, b15 59-60°, [α]D25 -0.30°; d-1-iodo-2-methylnonane, b4 86°, d425 1.254, [M]D25 2.54°; l-1-azido-2-methylnonane, b10 98-102°, d425 0.8658, nD25 1.4430, [M]D25 -0.74°; l-1-iodo-3-methylpentane, b12 54°, d425 1.3934, nD25 1.4866, [M]D25 -16.1°, maximum [M]D25 -43.9°; l-1-azido-3-methylpentane, b. 145-8°, nD25 1.4300, [M]D25 -9.63°, maximum [M]5875.625 -26.3° (in I); d-1-iodo-4-methylhexane, b13 74-5°, b103 124-6°, nD25 1.4852, d425 1.3579, [M]D25 8.20°, maximum [M]D25 26.2°; d-1-azido-4-methylhexane, b418 157°, d425 0.8636, nD25 1.4323, [M]5875.625 5.41°, maximum [M]5875.625 17.3° (in I.). All values for [M] are for the homogenous substance unless otherwise stated.

This compound(1-Iodo-2-methylbutane)SDS of cas: 616-14-8 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

Application In Synthesis of 1-Iodo-2-methylbutane. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1-Iodo-2-methylbutane, is researched, Molecular C5H11I, CAS is 616-14-8, about Long-chain syn-1-phenylalkane-1,3-diyl diacetates, related phenylalkane derivatives, and sec-alcohols, all possessing dominantly iso-branched chain termini, and 2/3-methyl-branched fatty acids from Primula veris L. (Primulaceae) wax. Author is Radulovic, Niko S.; Zivkovic Stosic, Milena Z..

Herein, the results of the first study of non-flavonoid constituents of aboveground surface-wax washings of Primula veris L. (Primulaceae) are presented. Chromatog. of the washings yielded a minor fraction composed of n-, iso-, and anteiso-series of long-chained syn-1-phenylalkane-1,3-diyl diacetates, 3-oxo-1-phenylalkan-1-yl acetates, 1-phenylalkane-1,3-diones, 1-hydroxy-1-phenylalkan-3-ones, sec-alcs. (2- to 10-alkanols), and n-, iso-, anteiso-, 2-methylalkanoic and 3-methylalkanoic acids; 118 of these constituents represent up to now unreported natural compounds The structural/stereochem. elucidation was accomplished by the synthesis of authentic standards, derivatization reactions, the use of gas chromatog. retention data and detailed 1D and 2D-NMR analyses of the obtained complex chromatog. fraction. Primula veris produces unusually high amounts of branched long-chained metabolites (>60%) except for the fatty acids where the percentage of branched isomers is comparable to the ones with n-chains. Noteworthy is the fact that long-chained α- and β-Me substituted fatty acids were detected herein for the first time in the kingdom Plantae.

This compound(1-Iodo-2-methylbutane)Application In Synthesis of 1-Iodo-2-methylbutane was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Total Solid Phase Syntheses of the Quinazoline Alkaloids: Verrucines A and B and Anacine, published in 2001-12-31, which mentions a compound: 198544-60-4, mainly applied to verrucine A B total solid phase synthesis; anacine total solid phase synthesis structure; quinazoline alkaloid total solid phase synthesis, Recommanded Product: (R)-(9H-Fluoren-9-yl)methyl (1-chloro-4-methyl-1-oxopentan-2-yl)carbamate.

The first total syntheses of verrucines A and B and anacine (revised structure) were accomplished on Sasrin resin. This work confirmed the structure of verrucine A and unambiguously showed verrucine B to be a derivative of D-phenylalanine and L-glutamine. The study also proved that anacine and its epimer are quinazoline alkaloids, not benzodiazepines as originally proposed. 1-Hydroxyverrucine B, derived from air oxidization of verrucine B, was also isolated and characterized.

This compound((R)-(9H-Fluoren-9-yl)methyl (1-chloro-4-methyl-1-oxopentan-2-yl)carbamate)Recommanded Product: (R)-(9H-Fluoren-9-yl)methyl (1-chloro-4-methyl-1-oxopentan-2-yl)carbamate was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Iodo-2-methylbutane, is researched, Molecular C5H11I, CAS is 616-14-8, about Long-chain syn-1-phenylalkane-1,3-diyl diacetates, related phenylalkane derivatives, and sec-alcohols, all possessing dominantly iso-branched chain termini, and 2/3-methyl-branched fatty acids from Primula veris L. (Primulaceae) wax.Application of 616-14-8.

Herein, the results of the first study of non-flavonoid constituents of aboveground surface-wax washings of Primula veris L. (Primulaceae) are presented. Chromatog. of the washings yielded a minor fraction composed of n-, iso-, and anteiso-series of long-chained syn-1-phenylalkane-1,3-diyl diacetates, 3-oxo-1-phenylalkan-1-yl acetates, 1-phenylalkane-1,3-diones, 1-hydroxy-1-phenylalkan-3-ones, sec-alcs. (2- to 10-alkanols), and n-, iso-, anteiso-, 2-methylalkanoic and 3-methylalkanoic acids; 118 of these constituents represent up to now unreported natural compounds The structural/stereochem. elucidation was accomplished by the synthesis of authentic standards, derivatization reactions, the use of gas chromatog. retention data and detailed 1D and 2D-NMR analyses of the obtained complex chromatog. fraction. Primula veris produces unusually high amounts of branched long-chained metabolites (>60%) except for the fatty acids where the percentage of branched isomers is comparable to the ones with n-chains. Noteworthy is the fact that long-chained α- and β-Me substituted fatty acids were detected herein for the first time in the kingdom Plantae.

《Long-chain syn-1-phenylalkane-1,3-diyl diacetates, related phenylalkane derivatives, and sec-alcohols, all possessing dominantly iso-branched chain termini, and 2/3-methyl-branched fatty acids from Primula veris L. (Primulaceae) wax》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Iodo-2-methylbutane)Application of 616-14-8.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

Category: thiomorpholine. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 1-Iodo-2-methylbutane, is researched, Molecular C5H11I, CAS is 616-14-8, about Radical Yields in the Radiolysis of Branched Hydrocarbons: Tertiary C-H Bond Rupture in 2,3-Dimethylbutane, 2,4-Dimethylpentane, and 3-Ethylpentane.

Gel permeation chromatog. has been applied to iodine scavenging studies of the distribution of radicals produced in the radiolysis of sym. branched hydrocarbons 2,3-dimethylbutane, 2,4-dimethylpentane, and 3-ethylpentane. The principal iodides observed are those expected as a result of simple bond rupture. In the case of 2,3-dimethylbutane all five expected iodides are readily resolvable and it is shown that the loss of H from a tertiary position is favored over loss from a primary position by a factor of ∼10. A similar ratio is also observed for 2,4-dimethylpentane. The higher ratio of 15 observed for 3-ethylpentane indicates a dependence on the number of tertiary sites on the alkane. The relative yield of ∼3.3 for the loss of secondary and primary H atoms from 2,4-dimethylpentane and 3-ethylpentane is similar to that for normal alkanes, indicating a negligible effect of the adjacent tertiary carbon. In all three cases the rupture of terminal C-C bonds is relatively infrequent with C-C rupture occurring preferentially at the bonds adjacent to the tertiary carbon.

《Radical Yields in the Radiolysis of Branched Hydrocarbons: Tertiary C-H Bond Rupture in 2,3-Dimethylbutane, 2,4-Dimethylpentane, and 3-Ethylpentane》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Iodo-2-methylbutane)Category: thiomorpholine.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《The infrared spectrum of the formate ion》. Authors are Schutte, C. J. H.; Buijs, K..The article about the compound:1-Iodo-2-methylbutanecas:616-14-8,SMILESS:CCC(CI)C).Application In Synthesis of 1-Iodo-2-methylbutane. Through the article, more information about this compound (cas:616-14-8) is conveyed.

The infrared spectra of anhydrous Ca(HCO2)2, Sr(HCO2)2, Ba(HCO2)2, and Pb(HCO2)2 show clearly the doubling of the fundamental bands of the formate ion owing to the existence of non-equivalent ions in the lattice. A new tetragonal phase of Ca(HCO2)2 precipitate when an organic solvent is added to an aqueous solution of Ca(HCO2)2. The new β phase belongs to space group D44-P412121, α = 9.46 A., c = 6.77 A., with 4 mols. per unit cell. The absorption bands for the β phase are single, in accordance with the crystallographic symmetry.

《The infrared spectrum of the formate ion》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Iodo-2-methylbutane)Application In Synthesis of 1-Iodo-2-methylbutane.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

Name: 1-Iodo-2-methylbutane. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Iodo-2-methylbutane, is researched, Molecular C5H11I, CAS is 616-14-8, about Hydrophobic Pocket Occupation Design of Difluoro-Biphenyl-Diarylpyrimidines as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: from N-Alkylation to Methyl Hopping on the Pyrimidine Ring. Author is Ding, Li; Pannecouque, Christophe; De Clercq, Erik; Zhuang, Chunlin; Chen, Fen-Er.

Considering the nonideal metabolic stability of the difluoro-biphenyl-diarylpyrimidine lead compound I, a series of novel alkylated difluoro-biphenyl-diarylpyrimidines were designed and synthesized based on their structure. Introducing alkyl or substituted alkyl groups on the linker region to block the potential metabolic sensitive sites generated 22 derivatives Among them, compound II with an N-Me group displayed excellent anti-HIV-1 activity and selectivity. The Me group was hopped to the central pyrimidine to occupy the small linker region and maintain the water-mediated hydrogen bond observed in the binding of compound I with RT. The resulting compound III exhibited an improved anti-HIV-1 activity, much lower cytotoxicity, and nanomolar activity toward multiple mutants. In addition, III has a better stability in human liver microsomes than I. Moreover, no apparent in vivo acute toxicity was observed in III-treated female, especially pregnant mice. This series of alkylated compounds with highly potency and safety represent a promising lead template for future discovery.

《Hydrophobic Pocket Occupation Design of Difluoro-Biphenyl-Diarylpyrimidines as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: from N-Alkylation to Methyl Hopping on the Pyrimidine Ring》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Iodo-2-methylbutane)Name: 1-Iodo-2-methylbutane.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 616-14-8, is researched, SMILESS is CCC(CI)C, Molecular C5H11IJournal, Angewandte Chemie, International Edition in English called Preparation of (S)-2-methylbutyl and (S)-sec-butyl ketones from optically active 2-methyl-1-butanol by the dithiane method, Author is Seebach, D.; Steinmueller, D., the main research direction is ketone; aldehyde; dithianes.HPLC of Formula: 616-14-8.

Optically active aldehydes and ketones EtMeCHCRO (where R = H, Me, Ph, Me3Si, C5H11, or 1-cyclohexenyl) were prepared by treating EtMeCHCHO, obtained from EtMeCHCH2OH, with CH2(CH2SH)2 to give 2-(1-methylpropyl)-1,3-dithiane, which was then alkylated and hydrolyzed. The loss of optical activity was <20% for the reaction sequence. 《Preparation of (S)-2-methylbutyl and (S)-sec-butyl ketones from optically active 2-methyl-1-butanol by the dithiane method》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Iodo-2-methylbutane)HPLC of Formula: 616-14-8.

Reference:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem