Kumaraswamy, B. published the artcileSynthesis, characterization and in vitro antimicrobial evaluation of some new amides of thiomorpholine carboxylate, Application of tert-Butyl thiomorpholine-4-carboxylate, the main research area is thiomorpholine carboxylate dioxide amide preparation antibacterial antifungal.
Synthesis and antimicrobial evaluation of some new amides of Thiomorpholine caboxylate is described. A series of new amides of Thiomorpholine caboxylate were synthesized by reacting 4-tert-Bu 2-Me thiomorpholine-2,4-dicarboxylate 1,1-dioxide with primary amines in presence of Tri-Me aluminum in toluene at ambient temperature in good yields. 4-Tert-Bu 2-Me thiomorpholine-2,4-dicarboxylate 1,1-dioxide was synthesized by reacting tert-Bu thiomorpholine-4-carboxylate 1,1-dioxide with Me chloroformate in presence of LiHMDS (1M in THF) at -78° for the first time. The newly synthesized compounds were characterized by IR, 1HNMR, 13C NMR, Mass spectral studies and elemental anal. Preliminary results revealed that the synthesized compounds were showed moderate to good antibacterial and antifungal activity.
International Journal of Pharmacy and Pharmaceutical Sciences published new progress about Antibacterial agents. 220655-09-4 belongs to class thiomorpholine, name is tert-Butyl thiomorpholine-4-carboxylate, and the molecular formula is C9H17NO2S, Application of tert-Butyl thiomorpholine-4-carboxylate.
Referemce:
Thiomorpholine – Wikipedia,
Thiomorpholine | C4H9NS – PubChem