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Rapid Access to Tricyclic Ring System Containing Isoindolone by Novel Diastereoselective Intramolecular Aldol-Type Cyclization of N-Substituted Phthalimides
The cyclization of N-substituted phthalimide to 3-hydroxyisoindolone derivatives has been successfully carried out by the base-promoted aldol-type reaction. The new morpholine and thiomorpholine derivatives have been synthesized and characterized.
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Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem