Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. , Name: (S)-alpha-(Chloromethyl)-2,4-dichlorobenzyl alcohol, 126534-31-4, Name is (S)-alpha-(Chloromethyl)-2,4-dichlorobenzyl alcohol, molecular formula is C8H7Cl3O, belongs to thiomorpholine compound. In a document, author is Blizzard, Timothy A., introduce the new discover.
Heterocyclic core analogs of a direct thrombin inhibitor
Thrombin is a serine protease that plays a key role in blood clotting. Pyrrolidine 1 is a potent thrombin inhibitor discovered at Merck several years ago. Seven analogs (2-8) of 1 in which the pyrrolidine core was replaced with various heterocycles were prepared and evaluated for activity against thrombin, clotting factors VIIa, IXa, Xa, and XIIa, and trypsin. The thiomorpholine analog 6 was the most active, essentially matching the thrombin inhibitory activity of 1 with slightly improved selectivity over trypsin. (C) 2014 Elsevier Ltd. All rights reserved.
The design and synthesis of related molecules that are more effective, more selective, and less toxic than aspirin are important objectives of biomedical research. I hope my blog about 126534-31-4 is helpful to your research. Name: (S)-alpha-(Chloromethyl)-2,4-dichlorobenzyl alcohol.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem