The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. In an article, author is Dal Magro, J, once mentioned the application of 72235-52-0, Name is (2,4-Difluorophenyl)methanamine, molecular formula is C7H7F2N, molecular weight is 143.134, MDL number is MFCD00010142, category is thiomorpholine. Now introduce a scientific discovery about this category, Recommanded Product: (2,4-Difluorophenyl)methanamine.
Nitrosation of 2-hydroxyethylpiperidine
The kinetics of the nitrosation of 2-hydroxyethylpiperidine have been studied in acidic (0.05-0.30 mol dm(-3) HClO4) aqueous media. The reaction rate is first order with respect to nitrite and amine and independent of acidity and shows an experimental isotope effect of 1.73. The most plausible mechanism involves the fast formation of an alkyl nitrite in the protonated amine (equilibrium constant estimated as 0.014 dm(3) mol(-1)). The loss of a proton from this intermediate is the rate-limiting step, and it is followed by a fast internal nitroso group transfer from the oxygen to the nitrogen atom to give the corresponding N-nitroso compound. A comparison of this nitrosation pathway of secondary amines in acid media with the nitrosation of thiomorpholine and piperidine, and with that of amines by alkyl nitrites in basic media is also discussed.
Recommanded Product: (2,4-Difluorophenyl)methanamine, The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find hit molecules. I hope my blog about 72235-52-0 is helpful to your research.
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem