Product Details of 99-61-6. In 2021 NAT PROD RES published article about RING in [Pan, Hongmei; Lu, Tong; Wu, Xuedan; Gu, Chengwen; Tao, Naili; Zhang, Biao; Wang, Ao; Chen, Guangmei; Zhang, Kehua; Jin, Jie] Anhui Jianzhu Univ, Sch Mat & Chem Engn, Hefei, Anhui, Peoples R China; [Cheng, Jie] Anhui Inst Food & Drug Control, Dept Chem, Hefei, Anhui, Peoples R China in 2021, Cited 17. The Name is 3-Nitrobenzaldehyde. Through research, I have a further understanding and discovery of 99-61-6.
A novel structure of sinomenine isoxazole derivatives is synthesised from sinomenine hydrochloride and aromatic aldehydes and requires six steps. 19 target compounds have been obtained in good yields. The sinomenine hydrochloride transforms to 4-alkynyl sinomenine, which is a key intermediate product to synthesise the target sinomenine isoxazole compounds, after a neutralisation reaction with ammonia and substitution reaction with 3-chloropropyne. Another key intermediate product is 1,3-dipole, which can be obtained from aromatic aldehyde. After treatment with hydroxylamine hydrochloride and then sodium carbonate solution, aromatic aldehyde is converted to aldehyde oxime, which reacts with N-chlorosuccinimide (NCS) to afford aryl hydroximino chloride. 1,3-Dipole is eventually formed in situ while triethylamine (TEA) in DMF is added dropwise. Then 4-alkynyl sinomenine is added to provide the sinomenine isoxazole derivative via 1,3-dipolar cycloaddition reaction as the key step. All the target compounds are characterised by melting point, H-1 NMR, C-13 NMR, HRMS and FT-IR spectroscopy.
Welcome to talk about 99-61-6, If you have any questions, you can contact Pan, HM; Lu, T; Wu, XD; Gu, CW; Tao, NL; Zhang, B; Wang, A; Chen, GM; Zhang, KH; Cheng, J; Jin, J or send Email.. Product Details of 99-61-6
Reference:
Thiomorpholine – Wikipedia,
,Thiomorpholine | C4H9NS – PubChem